Category: 104-01-8

Yang, Ya-Jun published the artcileDesign, synthesis and biological evaluation of dipeptides as novel non-covalent 20S proteasome inhibitors, Related Products of isoquinoline, the main research area is dipeptide proteasome inhibitor synthesis biol evaluation; 20S proteasome inhibitors; dipeptides; non-covalent.

Based on the interaction modes of the natural 20S proteasome inhibitors , we have previously discovered a dipeptide . To explore the SAR around compound , we designed and synthesized a series of dipeptides () with a fragment-based strategy. Among them, nine compounds showed significant inhibitory activities against the chymotrypsin-like activity of human 20S proteasome with IC50 values at the submicromolar level, which were comparable or even superior to the parent compound Meanwhile, they displayed no significant inhibition against trypsin-like and caspase-like activities of 20S proteasome. The results suggested the feasibility to design dipeptides as novel and potent 20S proteasome inhibitors.

Journal of Asian Natural Products Research published new progress about Cation-pi interaction. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tang, Hai-Jun published the artcileVisible-Light-Assisted Gold-Catalyzed Fluoroarylation of Allenoates, Name: 4-Methoxyphenylacetic acid, the main research area is gold catalyst fluoroarylation allenoate; allenoates; arylation; fluorination; gold; redox catalysis.

A strategically novel synthetic method for the fluoroarylation of allenic ester was developed that enables the expedient construction of a host of β-fluoroalkyl-containing cinnamate derivatives The reaction proceeds through visible-light-promoted gold redox catalysis, occurs smoothly under very mild reaction conditions, accommodates a large variety of functional groups, and more importantly allows the incorporation of fluorine and aryl groups with excellent regio- and stereoselectivity. The concomitant activation mode for both the allene motif and the hydrogen fluoride is key for the success of the reaction.

Angewandte Chemie, International Edition published new progress about Arylation (fluoroarylation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Haykal, Tarek published the artcileSafety and efficacy of aspirin for primary prevention of cancer: a meta-analysis of randomized controlled trials, Quality Control of 104-01-8, the main research area is meta analysis cancer aspirin safety efficacy; Aspirin; Bleeding; Cancer; Primary prevention.

Meta-anal. of In the United States, cancer is the second leading cause of mortality, and millions more battle cancer worldwide. As such, primary prevention of cancer is a major interest globally. Aspirin has been studied as a primary prevention method for multiple diseases, mainly cardiovascular disease and various forms of cancer. The role of aspirin as a primary prevention of cancer is still controversial and may be more beneficial in certain cancers over others. With rapidly surfacing large randomized controlled trials (RCTs) studying this subject, we aimed to evaluate the efficacy and safety of aspirin as a primary prophylaxis for cancer. A comprehensive electronic database search was conducted for all RCTs that compared aspirin vs. placebo for the prevention of any type of disease, and where cancer incidence or mortality was reported. The primary outcome was cancer related mortality. Secondary outcomes were cancer incidence, all-cause mortality, major bleeding, any bleeding and gastrointestinal (GI) bleeding. We calculated risk ratios (RRs) and 95% confidence intervals (CIs) using a random-effects model at the longest follow-up period. We included 16 RCTs with 104,018 total patients, mean age of 60.51 years, mean follow-up of 5.48 years, and a male percentage of 38.72%. We found that aspirin was not associated with a significant reduction of cancer-related mortality compared with placebo (RR 0.99; 95% CI: 0.87-1.12; P = 0.85: I2 = 41%). Compared with placebo, aspirin was not associated with significant reduction of all-cause mortality (RR 0.97; 95% CI: 0.92-1.02; P = 0.19; I2 = 13%) or cancer incidence (RR: 0.98; 95% CI: 0.92-1.04; P = 0.43; I2 = 16%). However, aspirin treatment was associated with significantly increased risks of any bleeding (RR 1.63; 95% CI: 1.31-2.03; P < 0.01), major bleeding (RR 1.41; 95% CI: 1.26-1.57; P < 0.01), and GI bleeding (RR 1.85; 95% CI: 1.38-2.48; P < 0.01) compared with placebo. Our study did not find any significant reductions in cancer-related mortality or cancer incidence when compared aspirin use with placebo or no aspirin. Our study also highlights that the use of aspirin for primary prevention of cancer was found to cause higher rates of bleeding (any bleeding, major bleeding, and GI bleeding) compared to placebo or no aspirin at the longest follow-up period with no significant benefit in cancer primary prevention. Journal of Cancer Research and Clinical Oncology published new progress about Digestive system hemorrhage. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Quality Control of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Babin, Victor published the artcilePhotochemical Strategy for Carbon Isotope Exchange with CO2, Name: 4-Methoxyphenylacetic acid, the main research area is photochem strategy carbon isotope exchange CO2.

A photocatalytic approach for carbon isotope exchange is reported. Utilizing [13C]CO2 and [14C]CO2 as primary C1 sources, this protocol allows the insertion of the desired carbon isotope into Ph acetic acids without the need for structural modifications or prefunctionalization in one single step. The exceptionally mild conditions required for this traceless transformation are in stark contrast with those for previous methods requiring the use of harsh thermal conditions.

ACS Catalysis published new progress about Exchange reaction (isotope). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ankudinov, Nikita M. published the artcileSynthesis of Rhodium Complexes with Chiral Diene Ligands via Diastereoselective Coordination and Their Application in the Asymmetric Insertion of Diazo Compounds into E-H Bonds, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is rhodium chiral diene complex preparation catalyst borylation silylation amination; crystal structure rhodium chiral fluorobenzobarrelene diene dimeric complex; mol structure rhodium chiral fluorobenzobarrelene diene dimeric complex; borane silane asym insertion diazoester diene rhodium catalyst; DFT calculations; carbene insertion; diene ligands; rhodium complexes.

A new method for the synthesis of chiral diene Rh catalysts is introduced. The readily available racemic tetrafluorobenzobarrelene complexes [(R2-TFB)RhCl]2 were separated into two enantiomers via selective coordination of one of them with the auxiliary S-salicyl-oxazoline ligand. One of the resulting chiral complexes with an exceptionally bulky diene ligand [(R,R-iPr2-TFB)RhCl]2 was an efficient catalyst for the asym. insertion of diazoesters into B-H and Si-H bonds giving the functionalized organoboranes and silanes with high yields (79-97%) and enantiomeric purity (87-98% ee). The stereoselectivity of separation via auxiliary ligand and that of the catalytic reaction was predicted by DFT calculations

Angewandte Chemie, International Edition published new progress about Amination, stereoselective. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Yan published the artcileCatalytic Asymmetric (3 + 3) Cycloaddition of Oxyallyl Zwitterions with α-Diazomethylphosphonates, Safety of 4-Methoxyphenylacetic acid, the main research area is pyridazinone preparation enantioselective; oxyallyl zwitterion diazomethylphosphonate cycloaddition chiral imidodiphosphoric acid catalyst.

The unique structure of oxyallyls represents a significant challenge for their catalytic asym. applications. Herein, an unprecedented chiral imidodiphosphoric acid-catalytic enantioselective (3 + 3) cycloaddition between oxyallyl zwitterions generated in situ from α-haloketones and α-diazomethylphosphonates was developed. Pharmaceutically interesting chiral pyridazine-4(1H)-ones were obtained in up to 98% yields with excellent stereoselectivities (up to 99% ee, > 99:1 dr).

Organic Letters published new progress about [3+3] Cycloaddition reaction. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Kai published the artcileSimple inorganic base promoted polycyclic construction using mucohalic acid as a C3 synthon: synthesis and AIE probe application of benzo[4,5]imidazo[1,2-a]pyridines, COA of Formula: C9H10O3, the main research area is benzoimidazopyridine preparation aggregation induced emission fluorescence; mucohalic acid benzimidazole heterocyclic compound polycyclic construction potassium carbonate.

A transition metal-free and efficient synthesis of fused azapolycycles via a multicomponent reaction has been developed using mucohalic acid as a C3 synthon. The reaction promoted by the simple inorganic base K2CO3 gives serial C1-functionalized benzo[4,5]imidazo[1,2-a]pyridine products using sym. and unsym. substrates with satisfactory yields. What is more, target compound I, as a representative example, exhibits the aggregation-induced emission (AIE) property, and its AIE performance can be applied to effectively sense picric acid (PA) with a detection limit and quenching constant of 1.15 x 10-7 M and 3.39 x 104 M-1, resp.

Organic Chemistry Frontiers published new progress about Aggregation-induced emission. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Kai published the artcileSimple inorganic base promoted C-N and C-C formation: synthesis of benzo[4,5]imidazo[1,2-a]pyridines as functional AIEgens used for detecting picric acid, Product Details of C9H10O3, the main research area is benzoimidazopyridine preparation optical property AIEgen detection picric acid; crystal structure mol benzoimidazopyridine preparation; bromo cinnamaldehyde benzimidazole tandem Michael addition cyclization base promoted.

Metal-free catalyzed intermol. tandem Michael addition/cyclization was developed for the synthesis of benzo[4,5]imidazo[1,2-a]pyridines I [R = H, Me, Ph, etc.; R1 = H, 7-Me, 7,8-Cl2, etc.] from α-bromocinnamaldehyde and 2-substituted benzimidazoles. The reaction promoted by a simple inorganic base displayed moderate to good yields and good functional group tolerance. The optical properties of some typical products I were investigated. Due to the presence of the benzene ring at the C1-position of compounds I which restricted intramol. motion, as a new type of aggregation-induced emission (AIE) luminogen (AIEgen), they showed very good solid-state fluorescence with quantum yields up to 88.80%. Importantly, the AIE performance of compound I [R = Me; R1 = H] could be useful to detect the nitroarom. explosive picric acid (PA) with a detection limit and quenching constant of 42.5 nM and 7.27 x 104 M-M, resp.

Organic & Biomolecular Chemistry published new progress about Aggregation-induced emission. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Wei published the artcileACQ-to-AIE Transformation by Regioisomerization of Rofecoxib Derivatives for Developing Novel Mechanochromic and Acidochromic Materials, Computed Properties of 104-01-8, the main research area is rofecoxib derivative aggregation induced emission regioisomerization mechanochromic acidochromic.

Design and syntheses of aggregation-induced emission (AIE) luminescent materials have attracted persistent attention in recent years. Among the various strategies to design novel AIE-active materials, conversion from aggregation-caused quenching (ACQ) to AIE is one of the most efficient because ACQ mols. are capable of being fluorescent in solution already, just not in the aggregated state. In this study, ACQ-to-AIE conversion was realized by regioisomerization of two rofecoxib derivatives named p-PDRF and o-PDRF. For these two compounds, p-PDRF with a piperidine group located on the para-position exhibited typical ACQ behavior while o-PDRF showed characteristic AIE activity when the piperidine group was relocated to the ortho-position. The single-crystal X-ray anal. revealed that the opposite fluorescent behavior in different states was mainly due to different structural conformations and different modes of mol. packing due to regioisomerization. Furthermore, o-PDRF also displayed apparent solvatochromism, mechanochromism, and acidochromism with reversible multi-stimulus behavior. Powder X-ray diffraction anal. indicated that the planarization of twisted structure and the destroy of crystalline structure was responsible for the tuned solid-state fluorescence. Taken together, the data showed that subtle migration of a piperidine group based on the rofecoxib scaffold altered the fluorescent properties of the two compounds significantly and that compound o-PDRF has the potential to be developed as mech.-force sensors and pH detectors.

Journal of Molecular Structure published new progress about Aggregation-induced emission. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Wei published the artcileA Precise Molecular Design to Achieve ACQ-to-AIE Transformation for Developing New Mechanochromic Material by Regio-Isomerization Strategy, Application of 4-Methoxyphenylacetic acid, the main research area is aggregation induced emission quenching fluorescence mechanochromic material.

Herein, we have designed and synthesized a series of MeO-rofecoxib based fluorophore (MORF1-6) for exploiting new promising mechanochromic luminescent (MCL) materials. Among them, MORF1 and MORF3 exhibit aggregation-induced emission (AIE) effects when the substituent is located at the ortho-position on the benzene ring of b. Meanwhile, by changing the type and position of the substituent, the corresponding compounds MORF2, MORF4, MORF5, MORF6 show aggregation caused-quenching (ACQ) behavior. These results demonstrate that the position and type of the substituent have a great effect on their fluorescent properties. Furthermore, an X-ray crystal structure anal. of MORF3 revealed that the intermol. π-π stacking was suppressed and intramol. hydrogen bonding were formed, which could effectively restrict the mol. motions, thus causing typical AIE effect and mechanochromic property. Finally, a re-writable data recording device was fabricated using MORF3 as the active material. Our mol. design strategy may provide a new avenue for achieving efficient MCL materials.

ChemistrySelect published new progress about Aggregation-induced emission. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem