Month: October 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147497-32-3,6-Bromo-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

Example 104 Preparation of 6-bromo-3,4-dihydro-2-(2-tetrahydro-2H-pyran-2-yloxy)ethyl)iso-quinolin-1-one A solution of 6-bromo-3,4-dihydroisoquinolin-1-one (0.36 g, 1.6 mmol) in DMF at 0 C. was treated with sodium hydride (60% dispersion in mineral oil, 0.15 g, 4 mmol), stirred for 1 h, treated with 2-(2-bromoethoxy)tetrahydro-2H-pyran (0.26 mL, 1.7 mmol), allowed to warm to room temperature, stirred overnight, diluted with water and extracted with EtOAc. The combined extracts were washed with water and brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash chromatography (silica, petroleum ether/ethyl acetate 2:8) to afford the title compound in 87% yield. 1H NMR (300 MHz, CDCl3): 7.92 (d, J=8.1 Hz, 1H); 7.46 (d, J=8.1 Hz, 1H); 7.27 (s, 1H); 4.59 (bs, 1H); 4.02-3.41 (m, 6H); 3.02-2.90 (m, 2H); 1.89-1.39 (m, 8H). LCMS (ESI) m/z 355.5 [M+H]+., 147497-32-3

147497-32-3 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one 21865450, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Wyeth; US2009/69300; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a warm solution of [Ru(eta6-p-cymene)Cl2]2 (61 mg, 0.1 mmol) in ethanol (5 ml) isoquinoline-3-carboxylic acid (HL7) (38 mg,0.2 mmol) in ethanol (3 ml) was added. The mixture was stirred at room temperature for 2 h. The yellow product was filtered off, washed with EtOH (5 ml) and dried in air., 6624-49-3

Big data shows that 6624-49-3 is playing an increasingly important role.

Reference£º
Article; Ivanovic?, Ivanka; Jovanovic?, Katarina K.; Gligorijevic?, Nevenka; Radulovic?, Sinis?a; Arion, Vladimir B.; Sheweshein, Khalil Salem A.M.; Tes?ic?, Z?ivoslav Lj.; Grguric?-S?ipka, Sanja; Journal of Organometallic Chemistry; vol. 749; (2014); p. 343 – 349;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90806-60-3,5-Methoxyisoquinoline-1-carbonitrile,as a common compound, the synthetic route is as follows.,90806-60-3

Cap- 138, step c (0.45 g, 2.44 mmol) was treated with 5N sodium hydroxide solution (10 mL) and the resulting suspension was heated at 85 C for 4 h, cooled to 25 C, diluted with dichloromethane and acidified with IN hydrochloric acid. The organic phase was separated, washed with brine, dried over Na2S04, concentrated to ? volume and filtered to afford Cap-138 as a yellow solid (0.44g, 88.9%). XH NMR (DMSO-d6, 400 MHz) delta 13.6 (br s, 1H), 8.56 (d, J= 6.0 Hz, 1H), 8.16 (d, J = 6.0 Hz, 1H), 8.06 (d, J= 8.8 Hz, 1H), 7.71-7.67 (m, 1H), 7.30 (d, J= 8.0 Hz, 1H), 4.02 (s, 3H); Rt = 0.70 min (Cond.-Dl); 95% homogenity index; LCMS: Anal. Calc. for [M+H]+ CnH10NO3: 204.07; found: 204.05.

The synthetic route of 90806-60-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; LAVOIE, Rico; BENDER, John A.; ROMINE, Jeffrey Lee; RUEDIGER, Edward H.; BACHAND, Carol; LOPEZ, Omar D.; CHEN, Qi; BELEMA, Makonen; KADOW, John F.; HAMANN, Lawrence G.; WO2011/60000; (2011); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

891782-60-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.891782-60-8,7-Bromo-3,4-dihydro-2H-isoquinolin-1-one,as a common compound, the synthetic route is as follows.

(b) 7-ethenyl-3,4-dihydro-l(2H)-isoquinolinoneA solution of 7-bromo-3,4-dihydro-l(2H)-isoquinolinone (0.679g, 3.004 mmol) and tetrakis(triphenylphosphine)palladium(0) (174 mg, 0.150 mmol) in 1,2-dimethoxyethane (30ml) was stirred at room temperature for 0.5h before addition of 2,4,6- trivinylcyclotriboroxane.pyridine complex (for a synthesis see Keri?s, Fergal; O’Shea, Donal F. J.Org.Chem. (2002), 67(14), 4968) (295 mg, 1.218 mmol), K2CO3 (415 mg, 3.004 mmol) and water (10 ml). The reaction was heated at reflux for 1.5h before cooling to room temperature and addition of water (50ml). The mixture was extracted with 10% methanol/dichloromethane (3 x 100ml), the organic layers were dried with magnesium sulphate and evaporated. Chromatography on silica, eluting with 0-100% ethyl acetate/hexane, gave the product (456 mg, 88%). MS (+ve ion electrospray) m/z 173 (MH+).

As the paragraph descriping shows that 891782-60-8 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/122258; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.164148-92-9,tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred solution of 2,4-dimethylimidazo[1,5-a]pyrimidine-8-carboxylic acid 3 (50 mg, 0.262 mmol), tert-butyl 6-amino-1,2,3,4-tetrahydroquinoline-2-carboxylate (72 mg, 0.288 mmol) and HATU (120 mg, 0.314 mmol) in DMF (1.0 mL) was added DIPEA (0.1 mL, 0.524 mmol), and the reaction mixture was stirred at room temperature for 16 h until the reaction was complete. The crude product was purified by prep-HPLC (MeCN/10 mM NH4HCO3) to give the Boc-protected form of the title compound as a white solid (62 mg, 56%). ES-MS m/z: 422 (M+H+). LC-MS Purity (254 nm): 96%; tR = 1.93 min.

164148-92-9, As the paragraph descriping shows that 164148-92-9 is playing an increasingly important role.

Reference£º
Patent; LYSOSOMAL THERAPEUTICS INC.; SKERLJ, Renato, T.; LANSBURY, Peter, T.; GOOD, Andrew, C.; BOURQUE, Elyse Marie, Josee; (134 pag.)WO2016/73889; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: At 0 ¡ãC and with stirring to the solution of 865 mg (5.0 mmol) of isoquinoline-3-carboxylic acid in 10 ml of anhydrous THF 675 mg (5.0 mmol) of HOBt was added to form reaction mixture A. The solution of 5.5 mmol of l-amino acid benzylester in 5 ml of anhydrous THF was adjusted pH 9 with triethylamine and stirred for 30 min to form mixture B. At 0 ¡ãC the mixtures A and B were mixed and then 1339 mg (6.5 mmol) of DCC was added. The reaction mixture was stirred at 0 ¡ãC for 2 h, at room temperature for12 h and TLC (ethyl acetate/petroleum ether, 1:2) indicated the complete disappearance of isoquinoline-3-carboxylic acid. The formed precipitates of DCU were removed by filtration and the filtrate was evaporated under vacumm. The residue was dissolved in 50 ml of ethyl acetate and the formed solution was washed successively with saturated aqueous solution of NaHCO3 (30 ml .x. 3), 5percent aqueous solution of KHSO4 (30 ml .x. 3) and saturated aqueous solution of NaCl (30 ml .x. 3) and dried over anhydrous Na2SO4. After filtration the filtrate was evaporated under vacumm and the residure was purified on silica gel chromatography (CHCl3:MeOH, 20:1) to give the title compounds., 6624-49-3

The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zheng, Meiqing; Yang, Yifan; Zhao, Ming; Zhang, Xiaoyi; Wu, Jianhui; Chen, Gong; Peng, Li; Wang, Yuji; Peng, Shiqi; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1672 – 1681;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1015070-56-0, 6-Bromoisoquinolin-4-ol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Bromo-4-hydroxyisoquinoline (15.7 g, 70.0 mmol) produced in Example 15 (15a) was dissolved in dimethylformamide (100 mL), to which 2-trimethylsilylethanol (100 mL), diisopropylethylamine (27.1 g, 210 mmol), 1,3-bis(diphenylphosphino)propane (8.57 g, 21.0 mmol), and palladium chloride (3.72 g, 21.0 mmol) were then added, followed by stirring at 60C for eight hours under a carbon monoxide atmosphere. The solvent was distilled off under reduced pressure. Water was added to the residue thus obtained, and the resulting mixture was extracted with dichloromethane. The resulting organic layer was dried over anhydrous sodium sulfate and the solvent was distilled off under reduced pressure. The residue thus obtained was purified by silica gel column chromatography((a mixed solvent of hexane : ethyl acetate – 1 : 1) : methanol, 100 : 0 – 70 : 30, V/V) to give the desired title compound (17.3 g, yield 85.4%). 1H-NMR (CDCl3 delta: 0. 11 (9H, s), 1.11-1.24 (2H, m), 4.46-4.55 (2H, m), 8.02 (1H, d, J = 8.4 Hz), 8.24 (1H, d, J = 8.4 Hz), 8.38 (1H, s), 8.87 (1H, s), 9.09 (1H, s)., 1015070-56-0

The synthetic route of 1015070-56-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2380878; (2011); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13130-79-5,1-Bromoisoquinolin-3-amine,as a common compound, the synthetic route is as follows.

To a stirred solution of 3-amino-1-bromoisoquinoline (444 mg, 2.00 mmol) in anhydrous dimethylformamide (10 mL) was added sodium hydride (60%, unwashed, 96 mg, 2.4 mmol) in one portion. The mixture was stirred at 25 C. for 5 min before 2-bromoethyl ether (90%, 250 muL, 2.00 mmol) was added. The mixture was stirred further at 25 C. for 5 h and at 75 C. for 72 h before it was cooled to 25 C., quenched with saturated ammonium chloride solution and diluted with ethyl acetate. The organic layer was separated, washed with water and brine, dried over Na2SO4, filtered and concentrated. Purification of the residue on silica gel eluting with 0% to 70% ethyl acetate/hexanes afforded Cap-143, step a as a yellow solid (180 mg, 31%). Rt=1.75 min (Cond.-MS-WI); 90% homogenity index; LCMS: Anal. Calc. for [M+H]+ C13H4BrN2O: 293.03; found: 293.04.

13130-79-5, 13130-79-5 1-Bromoisoquinolin-3-amine 289845, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; US2009/233925; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-05-9,6-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

200g of the starting material 6-bromo-isoquinoline was added to 2L of dichloromethane, then added portionwise content of 300g of 85% m-chloroperbenzoic acid, keeping the temperature between 25-30 & deg.] C, the addition was complete after the inter-chloroperbenzoic acid, the reaction system over 18h, TLC displayed after completion of the reaction, the entire system was filtered off with suction, the filter cake was dried to obtain the product of step S1 6-bromo-isoquinoline nitrogen oxide mixture.

34784-05-9, The synthetic route of 34784-05-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Luhe Ningyuan Technology Co., Ltd.; Jiang Yongjun; Xing Lixin; Liu Bo; (11 pag.)CN106831576; (2017); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

82827-09-6, 6-Bromoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

82827-09-6, Cesium carbonate (2.62 g), intermediate 1 (1.5 g) and (bromomethyl)cyclopropane (0.8 ml_) were stirred and heated at 50 0C for 4 hours. The mixture was allowed to cool then poured into water and extracted with ethyl acetate. The organic extracts were combined dried and evaporated under reduced pressure. The residue was triturated with ether and the sub-titled compound isolated by filtration (1.0g). MS: APCI(+ve) 277, 279 (M+H)+

The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/122765; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem