891782-60-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.891782-60-8,7-Bromo-3,4-dihydro-2H-isoquinolin-1-one,as a common compound, the synthetic route is as follows.
(b) 7-ethenyl-3,4-dihydro-l(2H)-isoquinolinoneA solution of 7-bromo-3,4-dihydro-l(2H)-isoquinolinone (0.679g, 3.004 mmol) and tetrakis(triphenylphosphine)palladium(0) (174 mg, 0.150 mmol) in 1,2-dimethoxyethane (30ml) was stirred at room temperature for 0.5h before addition of 2,4,6- trivinylcyclotriboroxane.pyridine complex (for a synthesis see Keri?s, Fergal; O’Shea, Donal F. J.Org.Chem. (2002), 67(14), 4968) (295 mg, 1.218 mmol), K2CO3 (415 mg, 3.004 mmol) and water (10 ml). The reaction was heated at reflux for 1.5h before cooling to room temperature and addition of water (50ml). The mixture was extracted with 10% methanol/dichloromethane (3 x 100ml), the organic layers were dried with magnesium sulphate and evaporated. Chromatography on silica, eluting with 0-100% ethyl acetate/hexane, gave the product (456 mg, 88%). MS (+ve ion electrospray) m/z 173 (MH+).
As the paragraph descriping shows that 891782-60-8 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/122258; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem