Tag: M.W:300-400

258515-65-0, tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 11.0 g (35.2 mmol) 7-bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid fert-butyl ester (preparation 27a) in 35 mL 1 ,4-dioxane is added 692 mg (3.56 mmol) copper(l)-iodide under argon. After flushing with argon, 0.75 mL (7.05 mmol) lambda/,lambda/-dimethylethylen-diamine and 10.6 g (70.5 mmol) sodium-iodide is added at RT. The reaction mixture is stirred 14 h at 1100C, cooled to RT and diluted with 5% aqueous ammonia-solution. The aqueous phase is extracted with EtOAc and the combined organic phase is washed with water, dried over MgSO4. After filtration and evaporation of the solvent, the residue is purified via chromatography (silica gel; Cyclohexane/EtOAc 85/15). Yield: 10.8 g (purity 75% (contains compound 27a), 78% of theory) ESI Mass spectrum: [M+H]+ = 360; Rf-value: 0.6 (silica gel, mixture F)., 258515-65-0

As the paragraph descriping shows that 258515-65-0 is playing an increasingly important role.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/103478; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.258515-65-0,tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.

V.5. a 7-lodo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl esterTo a mixture of 55,8 g (0,179 mol) 7-Bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester in 180 ml Dioxan are added 3,473 g (17,87 mmol) copper (I) iodide, 53,58 g (357,41 mmol) sodium iodide and 3,806 ml (35,74 mmol) N, N’- Dimethylethylenediamine. The reaction mixture is refluxed for 18 hours. 300 ml of 5% aqueous ammonia solution are added and the mixture is extracted two times with ethyl acetate. The combined organic extracts are extracted with aqueous ammonia solution and then water. The organic phases are dried over magnesium sulphate and concentrated to dryness. The residue is washed with petrol ether. Yield: 35,4 g (55% of theory),EII mass spectrum: m/z = 360 [M+H]+, 258515-65-0

258515-65-0 tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate 15885175, aisoquinoline compound, is more and more widely used in various fields.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

258515-65-0, tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7b 7-lodo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester To 11.0 g (35.2 mmol) 7-bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester (preparation 7a) in 35 mL 1 ,4-1 ,4-dioxanee is added 692 mg (3.56 mmol) copper(l)-iodide under argon. After flushing with argon, 0.75 mL (7.05 mmol) lambda/,lambda/-dimethylethylen-diamine and 10.6 g (70.5 mmol) sodium-iodide is added at RT. The reaction mixture is stirred 14 h at 1 100C, cooled to RT and diluted with 5% aqueous ammonia-solution. The aqueous phase is extracted with EtOAc and the combined organic phase is washed with water, dried over MgSO4. After filtration and evaporation of the solvent, the residue is purified via chromatography (silica gel; Cyclohexane/EtOAc 85/15). Yield: 10.8 g (purity 75% (contains compound 7a), 78% of theory) ESI Mass spectrum: [M+H]+ = 360 Rf-value: 0.6 (silica gel, mixture F)., 258515-65-0

The synthetic route of 258515-65-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/22979; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.258515-65-0,tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.

V.5. a 7-lodo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl esterTo a mixture of 55,8 g (0,179 mol) 7-Bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester in 180 ml Dioxan are added 3,473 g (17,87 mmol) copper (I) iodide, 53,58 g (357,41 mmol) sodium iodide and 3,806 ml (35,74 mmol) N, N’- Dimethylethylenediamine. The reaction mixture is refluxed for 18 hours. 300 ml of 5% aqueous ammonia solution are added and the mixture is extracted two times with ethyl acetate. The combined organic extracts are extracted with aqueous ammonia solution and then water. The organic phases are dried over magnesium sulphate and concentrated to dryness. The residue is washed with petrol ether. Yield: 35,4 g (55% of theory),EII mass spectrum: m/z = 360 [M+H]+, 258515-65-0

258515-65-0 tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate 15885175, aisoquinoline compound, is more and more widely used in various fields.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.258515-65-0,tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.

V.5. a 7-lodo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl esterTo a mixture of 55,8 g (0,179 mol) 7-Bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester in 180 ml Dioxan are added 3,473 g (17,87 mmol) copper (I) iodide, 53,58 g (357,41 mmol) sodium iodide and 3,806 ml (35,74 mmol) N, N’- Dimethylethylenediamine. The reaction mixture is refluxed for 18 hours. 300 ml of 5% aqueous ammonia solution are added and the mixture is extracted two times with ethyl acetate. The combined organic extracts are extracted with aqueous ammonia solution and then water. The organic phases are dried over magnesium sulphate and concentrated to dryness. The residue is washed with petrol ether. Yield: 35,4 g (55% of theory),EII mass spectrum: m/z = 360 [M+H]+, 258515-65-0

258515-65-0 tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate 15885175, aisoquinoline compound, is more and more widely used in various fields.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

258515-65-0, tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 11.0 g (35.2 mmol) 7-bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid fert-butyl ester (preparation 27a) in 35 mL 1 ,4-dioxane is added 692 mg (3.56 mmol) copper(l)-iodide under argon. After flushing with argon, 0.75 mL (7.05 mmol) lambda/,lambda/-dimethylethylen-diamine and 10.6 g (70.5 mmol) sodium-iodide is added at RT. The reaction mixture is stirred 14 h at 1100C, cooled to RT and diluted with 5% aqueous ammonia-solution. The aqueous phase is extracted with EtOAc and the combined organic phase is washed with water, dried over MgSO4. After filtration and evaporation of the solvent, the residue is purified via chromatography (silica gel; Cyclohexane/EtOAc 85/15). Yield: 10.8 g (purity 75% (contains compound 27a), 78% of theory) ESI Mass spectrum: [M+H]+ = 360; Rf-value: 0.6 (silica gel, mixture F)., 258515-65-0

As the paragraph descriping shows that 258515-65-0 is playing an increasingly important role.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/103478; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

258515-65-0, tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7b 7-lodo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester To 11.0 g (35.2 mmol) 7-bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester (preparation 7a) in 35 mL 1 ,4-1 ,4-dioxanee is added 692 mg (3.56 mmol) copper(l)-iodide under argon. After flushing with argon, 0.75 mL (7.05 mmol) lambda/,lambda/-dimethylethylen-diamine and 10.6 g (70.5 mmol) sodium-iodide is added at RT. The reaction mixture is stirred 14 h at 1 100C, cooled to RT and diluted with 5% aqueous ammonia-solution. The aqueous phase is extracted with EtOAc and the combined organic phase is washed with water, dried over MgSO4. After filtration and evaporation of the solvent, the residue is purified via chromatography (silica gel; Cyclohexane/EtOAc 85/15). Yield: 10.8 g (purity 75% (contains compound 7a), 78% of theory) ESI Mass spectrum: [M+H]+ = 360 Rf-value: 0.6 (silica gel, mixture F)., 258515-65-0

The synthetic route of 258515-65-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/22979; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.258515-65-0,tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.

V.5. a 7-lodo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl esterTo a mixture of 55,8 g (0,179 mol) 7-Bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester in 180 ml Dioxan are added 3,473 g (17,87 mmol) copper (I) iodide, 53,58 g (357,41 mmol) sodium iodide and 3,806 ml (35,74 mmol) N, N’- Dimethylethylenediamine. The reaction mixture is refluxed for 18 hours. 300 ml of 5% aqueous ammonia solution are added and the mixture is extracted two times with ethyl acetate. The combined organic extracts are extracted with aqueous ammonia solution and then water. The organic phases are dried over magnesium sulphate and concentrated to dryness. The residue is washed with petrol ether. Yield: 35,4 g (55% of theory),EII mass spectrum: m/z = 360 [M+H]+, 258515-65-0

258515-65-0 tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate 15885175, aisoquinoline compound, is more and more widely used in various fields.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

258515-65-0, tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7b 7-lodo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester To 11.0 g (35.2 mmol) 7-bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid te/f-butyl ester (preparation 7a) in 35 mL 1 ,4-1 ,4-dioxanee is added 692 mg (3.56 mmol) copper(l)-iodide under argon. After flushing with argon, 0.75 mL (7.05 mmol) lambda/,lambda/-dimethylethylen-diamine and 10.6 g (70.5 mmol) sodium-iodide is added at RT. The reaction mixture is stirred 14 h at 1 100C, cooled to RT and diluted with 5% aqueous ammonia-solution. The aqueous phase is extracted with EtOAc and the combined organic phase is washed with water, dried over MgSO4. After filtration and evaporation of the solvent, the residue is purified via chromatography (silica gel; Cyclohexane/EtOAc 85/15). Yield: 10.8 g (purity 75% (contains compound 7a), 78% of theory) ESI Mass spectrum: [M+H]+ = 360 Rf-value: 0.6 (silica gel, mixture F)., 258515-65-0

The synthetic route of 258515-65-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/22979; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

258515-65-0, tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 11.0 g (35.2 mmol) 7-bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid fert-butyl ester (preparation 27a) in 35 mL 1 ,4-dioxane is added 692 mg (3.56 mmol) copper(l)-iodide under argon. After flushing with argon, 0.75 mL (7.05 mmol) lambda/,lambda/-dimethylethylen-diamine and 10.6 g (70.5 mmol) sodium-iodide is added at RT. The reaction mixture is stirred 14 h at 1100C, cooled to RT and diluted with 5% aqueous ammonia-solution. The aqueous phase is extracted with EtOAc and the combined organic phase is washed with water, dried over MgSO4. After filtration and evaporation of the solvent, the residue is purified via chromatography (silica gel; Cyclohexane/EtOAc 85/15). Yield: 10.8 g (purity 75% (contains compound 27a), 78% of theory) ESI Mass spectrum: [M+H]+ = 360; Rf-value: 0.6 (silica gel, mixture F)., 258515-65-0

As the paragraph descriping shows that 258515-65-0 is playing an increasingly important role.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/103478; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem