258515-65-0, tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To 11.0 g (35.2 mmol) 7-bromo-3,4-dihydro-1 /-/-isoquinoline-2-carboxylic acid fert-butyl ester (preparation 27a) in 35 mL 1 ,4-dioxane is added 692 mg (3.56 mmol) copper(l)-iodide under argon. After flushing with argon, 0.75 mL (7.05 mmol) lambda/,lambda/-dimethylethylen-diamine and 10.6 g (70.5 mmol) sodium-iodide is added at RT. The reaction mixture is stirred 14 h at 1100C, cooled to RT and diluted with 5% aqueous ammonia-solution. The aqueous phase is extracted with EtOAc and the combined organic phase is washed with water, dried over MgSO4. After filtration and evaporation of the solvent, the residue is purified via chromatography (silica gel; Cyclohexane/EtOAc 85/15). Yield: 10.8 g (purity 75% (contains compound 27a), 78% of theory) ESI Mass spectrum: [M+H]+ = 360; Rf-value: 0.6 (silica gel, mixture F)., 258515-65-0
As the paragraph descriping shows that 258515-65-0 is playing an increasingly important role.
Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/103478; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem