Tag: 147497-32-3

147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b) Compound B (0.5 g, 2.21 mmol) was dissolved in dry DMF (3 mL) and 60% sodium hydride was added on ice bath(1.76 g, 4.42 mmol), stirred for 30 minutes, and added methyl 4-bromomethyl benzoate (0.557 g, 2.23 mmol).Stir at room temperature for 1 hour, pour into 100 mL crushed ice, extract with ethyl acetate (100 mL*3), combine the organic layers, and in turn water100 mL of 100 mL of saturated brine was extracted and dried over anhydrous sodium sulfate. The residue was purified by flash silica gel column chromatography usingElution with oleyl ether/ethyl acetate (V/V=5:1) gave compound C (0.74 g) as a pale yellow solid with a yield of 90%.

147497-32-3 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one 21865450, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jingkang; Xiong Bing; Zhao Lele; Li Jia; Geng Meiyu; Ma Lanping; Chen Danqi; Su Mingbo; Zhou Yubo; Hu Xiaobei; Liu Hongchun; Shen Aijun; (54 pag.)CN107879975; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the title A compound, 6-BROMO-3, 4-DIHYDRO-2H-ISOQUINOLIN-1-ONE (570 mg, 2.52 mmol) and benzyl bromide (390 UL, 3.28 mmol) in 10 mL of DMF is added sodium hydride (131 mg, 3.28 MMOL), and the reaction is stirred at RT for 3 h. The reaction is quenched with 1 N aqueous HCI, and the product is taken up in EtOAc. The organic solution is washed with water and brine, dried over anhydrous NA2SO4 and concentrated : Chromatography on silica (eluent : EtOAc/hexane – 1) affords 2-BENZYL-6-BROMO-3, 4-dihydro- 2H-isoquinolin-1-one.

As the paragraph descriping shows that 147497-32-3 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/65351; (2004); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE11; Step 11A;: A mixture of 6-bromo-3,4-dihydro-2H-isoquinolin-1-one (250 mg, 1.11 mmol), 4-trifluoromethyl-phenyl-boronic acid (251 mg, 1.33 mmol), 2 M aqueous sodium carbonate (1.10 mL), toluene (6 mL), ethanol (2 mL) and water (1 mL) was purged with nitrogen for 5 minutes. Palladium-tetrakis (triphenylphosphine) (64 mg, 0.055 mmol) was added and the mixture was heated with stirring at 80 C in a sealed pressure vessel for 19 h. Water (1 mL) was added and the reaction mixture was extracted with ethyl acetate (3 x 5 mL). The combined organic fractions were rinsed with water (10 mL) and concentrated in vacuo to give 475 mg of a light orange solid. Chromatography (silica gel 4: 96: 0.5, methanol: CH2Cl2: NH40H) afforded 189 mg (59 %) of lla as an off-white solid. LC-MS 292.0 (MH+).

147497-32-3 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one 21865450, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/103039; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

REFERENCE EXAMPLE 20; 6-Amino-2-isopropyl-3,4-dihydroisoqui?oli?-1(2H)-one; a) 6-Bromo-2-isopropyl”3s4-dihydroisoquinoSin-1 (2H)-one; 0.26 mL (2.76 mmoi) of 2-bromopropane, and 88 mg (2.2 mmol) of NaH were added to a solution of 6-bromo-3,4-dihydroisoquinoiin-1 (2H)-one (250 mg, 1.10 mmol) in DMF (2 mL). The reaction mixture was stirred at 100 0C overnight. The crude product was diluted with H2O and extracted thrice with EtOAc. The combined organic phases were separated, dried over Na2SO4 and the solvent was evaporated. The crude product thus obtained was purified by column chromatography over silica gel, using hexane/EtOAc mixtures of increasing polarity as eluent, and 87 mg of the desired compound were obtained (yield: 29%).

As the paragraph descriping shows that 147497-32-3 is playing an increasingly important role.

Reference£º
Patent; PALAU PHARMA, S.A.; SALAS SOLANA, Jorge; ALMANSA ROSALES, Carmen; SOLIVA SOLIVA, Robert; FONTES USTRELL, Montserrat; COMELLES ESPUGA, Josep; WO2010/34740; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem