147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE11; Step 11A;: A mixture of 6-bromo-3,4-dihydro-2H-isoquinolin-1-one (250 mg, 1.11 mmol), 4-trifluoromethyl-phenyl-boronic acid (251 mg, 1.33 mmol), 2 M aqueous sodium carbonate (1.10 mL), toluene (6 mL), ethanol (2 mL) and water (1 mL) was purged with nitrogen for 5 minutes. Palladium-tetrakis (triphenylphosphine) (64 mg, 0.055 mmol) was added and the mixture was heated with stirring at 80 C in a sealed pressure vessel for 19 h. Water (1 mL) was added and the reaction mixture was extracted with ethyl acetate (3 x 5 mL). The combined organic fractions were rinsed with water (10 mL) and concentrated in vacuo to give 475 mg of a light orange solid. Chromatography (silica gel 4: 96: 0.5, methanol: CH2Cl2: NH40H) afforded 189 mg (59 %) of lla as an off-white solid. LC-MS 292.0 (MH+).
147497-32-3 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one 21865450, aisoquinoline compound, is more and more widely used in various.
Reference£º
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/103039; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem