Tag: 191.2264

Synthesis of (-)-(S)-norlaudanosine, (+)-(R)-O,O-dimethylcoclaurine, and (+)-(R)-salsolidine by alkylation of an α-aminonitrile was written by Werner, Frank;Blank, Nancy;Opatz, Till. And the article was included in European Journal of Organic Chemistry in 2007.Application In Synthesis of 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

A short asym. synthesis of 1-substituted 1,2,3,4-tetrahydroisoquinoline alkaloids by deprotonation of an unprotected α-aminonitrile and alkylation of the resulting carbanion followed by spontaneous elimination of HCN and asym. reduction is described. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Application In Synthesis of 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Application In Synthesis of 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sequential One-Pot Vilsmeier-Haack and Organocatalyzed Mannich Cyclizations to Functionalized Benzoindolizidines and Benzoquinolizidines was written by Outin, Johanne;Quellier, Pauline;Belanger, Guillaume. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

The development of new one-pot sequential cyclizations involving a Vilsmeier-Haack reaction followed by an organocatalyzed Mannich reaction is reported. This synthetic strategy gives access to functionalized indolizidines and quinolizidines in one operation from readily synthesized precursors. Yields and diastereoselectivities are good to excellent when formamides are used to trigger the key step, bearing either an electron-rich aryl or a pyrrole as the nucleophilic partner in the first cyclization. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Novel [l,2,4]triazolo[3,4-a]isoquinoline chalcones as new chemotherapeutic agents: Block IAP tyrosine kinase domain and induce both intrinsic and extrinsic pathways of apoptosis was written by Mohamed, Magda F.;Sroor, Farid M.;Ibrahim, Nada S.;Salem, Ghada S.;El-Sayed, Hadeer H.;Mahmoud, Marwa M.;Wagdy, Menna-Allah M.;Ahmed, Amina M.;Mahmoud, Aya-Allah T.;Ibrahim, Somia S.;Ismail, Mariam M.;Eldin, Sanaa Mohy;Saleh, Fatma M.;Hassaneen, Hamdi M.;Abdelhamid, Ismail A.. And the article was included in Investigational New Drugs in 2021.Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

Summary: Two novel chemotherapeutic chalcones were synthesized and their structures were confirmed by different spectral tools. Theor. studies such as mol. modeling were done to detect the mechanism of action of these compounds In vitro cytotoxicity showed a strong effect against all tested cell lines (MCF7, A459, HepG2, and HCT116), and low toxic effect against normal human melanocytes (HFB4). The lung carcinoma cell line was chosen for further mol. studies. Real-time PCR demonstrated that the two compounds upregulated gene expression of (BAX, p53, casp-3, casp-8, casp-9) genes and decreased the expression of anti-apoptotic genes bcl2, CDK4, and MMP1. Flow-cytometry indicated that cell cycle arrest of A459 was induced at the G2/M phase and the apoptotic percentage increased significantly compared to the control sample. Cytochrome c oxidase and VEGF enzyme activity were detected by ELISA assay. SEM tool was used to follow the morphol. changes that occurred on the cell surface, cell granulation, and average roughness of the cell surface. The change in the number and morphol. of mitochondria, cell shrinkage, increase in the number of cytoplasmic organelles, membrane blebbing, chromatin condensation, and apoptotic bodies were observed using TEM. The obtained data suggested that new chalcones exerted their pathways on lung carcinoma through induction of two pathways of apoptosis. Graphical abstractNovel chalcones were prepared and confirmed by different spectral tools. Docking simulations were done to detect the mechanism of action. In vitro cytotoxicity indicated a strong effect against different cancer cell lines and low toxic effects against normal human melanocytes (HFB4). The lung carcinoma cell line was chosen for further mol. studies that include Real-time PCR, Flow-cytometry, Cytochrome c oxidase, and ELISA assay. SEM and TEM tool were used to follow the morphol. changes occurred on the cell surface [graphic not available: see fulltext]. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Photochemical α-Aminonitrile Synthesis Using Zn-Phthalocyanines as Near-Infrared Photocatalysts was written by Grundke, Caroline;Silva, Rodrigo C.;Kitzmann, Winald R.;Heinze, Katja;de Oliveira, Kleber T.;Opatz, Till. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 3382-18-1 This article mentions the following:

While photochem. transformations with sunlight almost exclusively utilize the UV-vis part of the solar spectrum, the majority of the photons emitted by the sun have frequencies in the near-IR region. Phthalocyanines show high structural similarity to the naturally occurring light-harvesting porphyrins, chlorins, and mainly bacteriochlorins and are also known for being efficient and affordable near-IR light absorbers as well as triplet sensitizers for the production of singlet oxygen. Although having been neglected for a long time in synthetic organic chem. due to their low solubility and high tendency toward aggregation, their unique photophys. properties and chem. robustness make phthalocyanines attractive photocatalysts for the application in near-IR-light-driven synthesis strategies. Herein, authors report a cheap, simple, and efficient photocatalytic protocol, which is easily scalable under continuous-flow conditions. Various phthalocyanines were studied as near-IR photosensitizers in oxidative cyanations of tertiary amines to generate α-aminonitriles, a synthetically versatile compound class. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1HPLC of Formula: 3382-18-1).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.HPLC of Formula: 3382-18-1

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Asymmetric acyl-Strecker reaction promoted by novel thiourea organocatalyst was written by Kanemitsu, Takuya;Toyoshima, Eisuke;Miyazaki, Michiko;Nagata, Kazuhiro;Itoh, Takashi. And the article was included in Heterocycles in 2010.HPLC of Formula: 3382-18-1 This article mentions the following:

An asym. acyl-Strecker reaction using a novel thiourea organocatalyst was described. Screening experiments of the catalysts revealed that a bifunctional organocatalyst afforded an enantio-enriched product via an unique mechanism. That is, dihydroisoquinolines were converted to a corresponding 1-cyano-1,2,3,4-tetrahydroisoquinolines using the bifunctional thiourea catalyst derived from Betti base in moderate yield and enantioselectivity. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1HPLC of Formula: 3382-18-1).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.HPLC of Formula: 3382-18-1

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Synthesis of (-)-(S)-norlaudanosine, (+)-(R)-O,O-dimethylcoclaurine, and (+)-(R)-salsolidine by alkylation of an α-aminonitrile was written by Werner, Frank;Blank, Nancy;Opatz, Till. And the article was included in European Journal of Organic Chemistry in 2007.Application In Synthesis of 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

A short asym. synthesis of 1-substituted 1,2,3,4-tetrahydroisoquinoline alkaloids by deprotonation of an unprotected α-aminonitrile and alkylation of the resulting carbanion followed by spontaneous elimination of HCN and asym. reduction is described. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Application In Synthesis of 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Application In Synthesis of 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sequential One-Pot Vilsmeier-Haack and Organocatalyzed Mannich Cyclizations to Functionalized Benzoindolizidines and Benzoquinolizidines was written by Outin, Johanne;Quellier, Pauline;Belanger, Guillaume. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

The development of new one-pot sequential cyclizations involving a Vilsmeier-Haack reaction followed by an organocatalyzed Mannich reaction is reported. This synthetic strategy gives access to functionalized indolizidines and quinolizidines in one operation from readily synthesized precursors. Yields and diastereoselectivities are good to excellent when formamides are used to trigger the key step, bearing either an electron-rich aryl or a pyrrole as the nucleophilic partner in the first cyclization. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Reactivity of N-(4-Nitrophenyl)propionohydrazonoyl Bromide. Synthesis and Antimicrobial Study of Thiadiazoles and 4,6-Dithia-1,2,9-triazaspiro-[4.4]-non-2-en-8-ones was written by Mohamed Teleb, Mohamed A.;Kamel, Monica G.;Ead, Hamed A.;Hassaneen, Hamdi M.;Saleh, Fatma M.. And the article was included in Polycyclic Aromatic Compounds.Quality Control of 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

Treatment of thioanilides with N-(4-nitrophenyl)propionohydrazonoyl bromide in refluxing chloroform in the presence of triethylamine gave thiadiazoles. Stirring of 2-((methylthio)carbonthioyl)hydrazonoes with hydrazonoyl bromide in ethanol in the presence of triethylamine at room temperature afforded the corresponding thiadiazole derivatives Also, reaction of 5-arylidene-3-phenyl-2-thioxothiazolidin-4-ones and hydrazonoyl bromide in chloroform in the presence of triethylamine at reflux to yield the corresponding 4,6-dithia-1,2,9-triazaspiro[4.4]non-2-en-8-one derivatives The structures of the latter new products were identified by elemental anal. and spectral data. Antimicrobial studies were performed against all synthesized compounds Compounds , , and were exhibited high antimicrobial activities against the tested microorganisms. The other compounds showed no activities. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Quality Control of 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Quality Control of 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

UPLC-MS coupled with a dynamic multiple data processing method for the comprehensive detection of the chemical constituents of the herbal formula San-Miao-Wan was written by Zou, Di;Zhang, Ai-hua;Yan, Guang-li;Tan, Yun-long;Sun, Hui;Wang, Xi-jun. And the article was included in Analytical Methods in 2014.Product Details of 3382-18-1 This article mentions the following:

San-Miao-Wan (SMW) is a combination prescription of Cortex Phellodendri Chinensis, Rhizoma Atractylodis, and Radix Achyranthis Bidentatae commonly used to treat arthritis and hyperuricemia, described in the State Pharmacopoeia of the People’s Republic of China. However, despite numerous pharmacol. studies, the phytochem. constituents of SMW were not conclusively identified. In the present study, a universally applicable UPLC-ESI-Q-TOF-MS technique coupled with a multiple data processing approach (Mdpa) was developed to carry out comprehensive detection of the chem. constituents of SMW. The Mdpa method can efficiently deal with the large volumes of mass data collected via the use of spectral and chromatog. search algorithms that detect ions at low concentrations Using an UPLC system, the total anal. time for separation was < 20 min without the loss of any resolution In the principal component anal. VIP-plot, 77 ions of interest (36 ions in pos. mode, 43 ions in neg. mode, and 2 ions in both modes) were extracted Based on the MS fragmentation patterns of the reference standards, a total of 71 components were identified or tentatively characterized by comparing their retention times, UV and MS spectra with those of reference standards, or through the matching of empirical information with those of the published components in the inhouse library. Our results indicated that the developed method could be used as a rapid and effective technique for the structural characterization of phytochem. constituents in SMW. This work is also expected to provide comprehensive information for the quality evaluation study of SMW. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Product Details of 3382-18-1).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Product Details of 3382-18-1

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Synthesis, cytotoxicity and docking simulation of bioactive [1,2,4]triazolo[3,4-a]dihydroisoquinoline chalcone derivatives was written by Teleb, Mohamed A. M.;Hassan, Nourhan;Hassaneen, Hamdi M.;Hassaneen, Huwaida M. E.;Laboud, Yara N.;Saleh, Fatma M.. And the article was included in Heterocycles in 2022.Synthetic Route of C11H13NO2 This article mentions the following:

1-(1-Aryl-8,9-dimethoxy-1,5,6,10b-tetrahydro-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)ethan-1-ones were prepared via reaction of C-acetylmethanohydrazonoyl chlorides with 6,7-dimethoxy-3,4-dihydroisoquinoline. Treatment of the latter products with 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde derivatives in ethanol in the presence of sodium hydroxide solution at room temperature afforded chalcones I (X = Me, OMe; Y = H, Me, OMe, Cl). Cytotoxic assay was performed for in vitro antitumor screening against caucasian breast adenocarcinoma (MCF7) and hepatocellular carcinoma (HepG2) cell lines. Chalcones I (X = Y = Me) and I (X = OMe, Y = H) have promising cytotoxic effects against MCF7 with IC50 values 8.0 and 7.5渭g/mL, resp. Mol. docking using Mcule.com was carried out, for the most potent compounds I (X = Y = Me) and I (X = OMe, Y = H) against two protiens which are EGFR and DHFR. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Synthetic Route of C11H13NO2).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Synthetic Route of C11H13NO2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem