Tag: 191.2264

Wang, Kaikai et al. published their research in Molecules in 2022 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Reference of 3382-18-1

Facile Synthesis of Tricyclic 1,2,4-Oxadiazolines-Fused Tetrahydro-Isoquinolines from Oxime Chlorides with 3,4-Dihydroisoquinoline Imines was written by Wang, Kaikai;Li, Yanli;Zhang, Wei;Chen, Rongxiang;Ma, Xueji;Wang, Mingyue;Zhou, Nan. And the article was included in Molecules in 2022.Reference of 3382-18-1 This article mentions the following:

A mild and efficient strategy for the synthesis of tricyclic 1,2,4-oxadiazolines-fused tetrahydroisoquinolines derivatives via [3 + 2] cycloaddition reaction was reported. The reactions provided the functionalized tricyclic 1,2,4-oxadiazolines in high yields (up to 96%). This protocol was simple and easy to handle. Moreover, a gram-scale experiment further highlights the synthetic utility. The chem. structure of the product was determined by X-ray single-crystal structure anal. A possible mechanism for this transformation was proposed to explain the reaction process. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Reference of 3382-18-1).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Reference of 3382-18-1

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Osyanin, V. A. et al. published their research in Crystallography Reports in 2015 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline

Synthesis and structure of 15-(1-benzyl-1H-imidazol-5-yl)-9,10-dimethoxy-12,13-dihydro-7aH,15H-naphtho[1′,2′:5,6][1,3]oxazino[2,3-a]isoquinoline was written by Osyanin, V. A.;Ivleva, E. A.;Rybakov, V. B.;Klimochkin, Yu. N.. And the article was included in Crystallography Reports in 2015.Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

The synthesis and X-ray diffraction study of 15-(1-benzyl-1H-imidazol-5-yl)-9,10-dimethoxy-12,13-dihydro-7aH,15H-naphtho[1′,2′:5,6][1,3]oxazino[2,3-a]isoquinoline (C32H29N3O3) is reported. The crystal belongs to the triclinic system, space group P1, a = 7.0319(2) 掳, b = 12.2989(6) 掳, c = 14.8284(7) 掳, 伪 = 84.606(4)掳, 尾 = 88.741(3)掳, and 纬 = 86.227(3)掳, Z = 2, V = 1273.82(9) 掳3, 蟻calcd = 1.313 g/cm3 [T = 100(2) K]. In the mol., the oxazine ring adopts a half-chair conformation. The positions of two tertiary hydrogen atoms are found, and it is shown that the compound is a trans isomer. The bond lengths and angles in the mol. are standard for this class of compounds In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Wang, Kaikai et al. published their research in Molecules in 2022 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Reference of 3382-18-1

Facile Synthesis of Tricyclic 1,2,4-Oxadiazolines-Fused Tetrahydro-Isoquinolines from Oxime Chlorides with 3,4-Dihydroisoquinoline Imines was written by Wang, Kaikai;Li, Yanli;Zhang, Wei;Chen, Rongxiang;Ma, Xueji;Wang, Mingyue;Zhou, Nan. And the article was included in Molecules in 2022.Reference of 3382-18-1 This article mentions the following:

A mild and efficient strategy for the synthesis of tricyclic 1,2,4-oxadiazolines-fused tetrahydroisoquinolines derivatives via [3 + 2] cycloaddition reaction was reported. The reactions provided the functionalized tricyclic 1,2,4-oxadiazolines in high yields (up to 96%). This protocol was simple and easy to handle. Moreover, a gram-scale experiment further highlights the synthetic utility. The chem. structure of the product was determined by X-ray single-crystal structure anal. A possible mechanism for this transformation was proposed to explain the reaction process. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Reference of 3382-18-1).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Reference of 3382-18-1

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Osyanin, V. A. et al. published their research in Crystallography Reports in 2015 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline

Synthesis and structure of 15-(1-benzyl-1H-imidazol-5-yl)-9,10-dimethoxy-12,13-dihydro-7aH,15H-naphtho[1′,2′:5,6][1,3]oxazino[2,3-a]isoquinoline was written by Osyanin, V. A.;Ivleva, E. A.;Rybakov, V. B.;Klimochkin, Yu. N.. And the article was included in Crystallography Reports in 2015.Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

The synthesis and X-ray diffraction study of 15-(1-benzyl-1H-imidazol-5-yl)-9,10-dimethoxy-12,13-dihydro-7aH,15H-naphtho[1′,2′:5,6][1,3]oxazino[2,3-a]isoquinoline (C32H29N3O3) is reported. The crystal belongs to the triclinic system, space group P1, a = 7.0319(2) °, b = 12.2989(6) °, c = 14.8284(7) °, α = 84.606(4)°, β = 88.741(3)°, and γ = 86.227(3)°, Z = 2, V = 1273.82(9) °3, ρcalcd = 1.313 g/cm3 [T = 100(2) K]. In the mol., the oxazine ring adopts a half-chair conformation. The positions of two tertiary hydrogen atoms are found, and it is shown that the compound is a trans isomer. The bond lengths and angles in the mol. are standard for this class of compounds In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Al-Hiari, Yusuf M. et al. published their research in Jordan Journal of Pharmaceutical Sciences in 2009 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Category: isoquinoline

Synthesis of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, Part I: Grignard synthesis of 1-(substituted benzyl)-1,2,3,4-tetrahydroisoquinoline models with potential antibacterial activity was written by Al-Hiari, Yusuf M.;Sweileh, Bassam A.;Shakya, Ashok K.;Abu Sheikha, Ghassan;Almuhtaseb, Sabah I.. And the article was included in Jordan Journal of Pharmaceutical Sciences in 2009.Category: isoquinoline This article mentions the following:

(Benzyl)tetrahydroisoquinoline alkaloids have interesting biol. activity. 1-(Substituted benzyl)-1,2,3,4-tetrahydroisoquinolines, e.g., I, were prepared via Grignard addition to 3,4-dihydroisoquinolines in good yields. But this procedure is failed for the case of benzyloxybenzyl- and 4-hydroxybenzyl Grignards due to side reactions and low chem. yields. Therefore an alternative strategy based on lithiation of N-benzoyl-1,2,3,4-tetrahydroisoquinoline followed by alkylation was applied and the desired products were obtained in reasonable yields. All products and intermediates were isolated, purified and their structure confirmed using NMR, IR and MS techniques. The antibacterial activity against tetracycline resistant MRSA revealed that some compounds were identified as being of potential interest. In particular, some of the prepared products showed interesting antibacterial activity with MIC ranges of 10 to 64 μg/mL. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Category: isoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Category: isoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Osyanin, V. A. et al. published their research in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2011 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Quality Control of 6,7-Dimethoxy-3,4-dihydroisoquinoline

Reactions of 6,7-dimethoxy-3,4-dihydroisoquinoline with o-quinone methides was written by Osyanin, V. A.;Ivleva, E. A.;Osipov, D. V.;Klimochkin, Yu. N.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2011.Quality Control of 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

Products of heterocyclization, 9,10-dimethoxy-12,13-dihydro-7aH,15H-naphtho[1′,2′:5,6][1,3]oxazino[2,3-a]isoquinolines, were isolated on condensation of 6,7-dimethoxy-3,4-dihydroisoquinoline with 1-[(dimethylamino)methyl]-2-naphthols. In the case of 2-hydroxybenzyl alcs., products of an aza-Michael reaction, 2-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]phenols were obtained. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Quality Control of 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Quality Control of 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Wu, T. Robert et al. published their research in Journal of the American Chemical Society in 2006 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Synthetic Route of C11H13NO2

Asymmetric Allylboration of Cyclic Imines and Applications to Alkaloid Synthesis was written by Wu, T. Robert;Chong, J. Michael. And the article was included in Journal of the American Chemical Society in 2006.Synthetic Route of C11H13NO2 This article mentions the following:

Treatment of cyclic imines with 3,3′-disubstituted binaphthol modified allylboronates provides the expected allylated products in good yields and with high stereoselectivities (91-99% ee). The products may be readily transformed into several naturally occurring alkaloids. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Synthetic Route of C11H13NO2).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Synthetic Route of C11H13NO2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Thasana, Nopporn et al. published their research in Synlett in 2008 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline

A facile synthesis of telisatin A via microwave-promoted annulation and Reformatsky reaction was written by Thasana, Nopporn;Bjerke-Kroll, Ben;Ruchirawat, Somsak. And the article was included in Synlett in 2008.Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

A facile one-pot synthesis of 2,3-dioxopyrrolo[2,1-a]isoquinolines was reported involving the ring formation of aryl pyruvate derivatives with 3,4-dihydroisoquinolines under basic conditions and utilizing the Reformatsky reaction. Using microwave irradiation, the required compounds were obtained in moderate to good yields. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Li, Deng Yuan et al. published their research in Journal of Organic Chemistry in 2014 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Category: isoquinoline

Transition Metal-Free Cascade Reactions of Alkynols to Afford Isoquinolin-1(2H)-one and Dihydroisobenzofuran Derivatives was written by Li, Deng Yuan;Shi, Ke Ji;Mao, Xiao Feng;Chen, Guo Rong;Liu, Pei Nian. And the article was included in Journal of Organic Chemistry in 2014.Category: isoquinoline This article mentions the following:

Transition metal-free cascade reactions of alkynols with imines have been achieved using potassium tert-butoxide as catalyst. Switching the reaction solvent gives two kinds of products in good yield: isoquinolin-1(2H)-one derivatives and dihydroisobenzofuran derivatives Thus, e.g., reaction of alkynol I with imine II in DMSO in presence of t-BuOK afforded isoquinolin-1(2H)-one III in 89% yield, whereas reaction in THF afforded dihydroisobenzofuran IV in 92% yield. This approach was used to generate the natural product 8-oxypseudopalmatine in a two-step procedure from com. available starting materials. Addnl., multicomponent reactions of alkynols, aldehydes, and amines were also successfully achieved to afford isoquinolin-1(2H)-one derivatives In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Category: isoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Category: isoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Pelletier, Sophie M.-C. et al. published their research in Organic Letters in 2009 | CAS: 3382-18-1

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline

Nitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones was written by Pelletier, Sophie M.-C.;Ray, Peter C.;Dixon, Darren J.. And the article was included in Organic Letters in 2009.Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:

An efficient three-component nitro-Mannich/lactamization cascade of Me 3-nitropropanoate with in situ formed acyclic imines for the direct preparation of pyrrolidinone derivatives has been developed. The reaction is easy to perform, broad in scope, and highly diastereoselective and may be extended to cyclic imines allowing the direct formation of polycyclic pyrrolidinone derivatives In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Safety of 6,7-Dimethoxy-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem