Tag: 1532-97-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-97-4,4-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

Reference Example 1; 4-Fluoroisoquinoline; A solution of n-butyllithium in n-hexane (1.58 M, 60.1 ml, Kanto Chemicals) was added with tetrahydrofuran (345 ml), and the mixture was sufficiently cooled on a dry ice-acetone bath. The mixture was added dropwise with a solution of 4-bromoisoquinoline (9.0 g, Tokyo Kasei Kogyo) in tetrahydrofuran (65 ml) over 1 hour so that the temperature of the reaction mixture should not exceed -65¡ã C. The mixture was stirred at the same temperature for 30 minutes, and then added dropwise with a solution of N-fluorobenzenesulfonimide (30 g, Tokyo Kasei Kogyo) in tetrahydrofuran (100 ml) over 1 hour so that the temperature of the reaction mixture should not exceed -65¡ã C. Subsequently, the mixture was stirred at the same temperature for 1 hour, then the cooling bath was removed, and the mixture was gradually warmed to room temperature. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate (300 ml) and ethyl acetate (300 ml), and stirred at room temperature for 12 hours. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate 3 times (200 ml for each time). The combined organic layer was washed with saturated brine (500 ml), and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, the residue was added with chloroform (250 ml), and the insoluble solids were removed by filtration. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel chromatography (n-hexane:ethyl acetate=5:1) to obtain the title compound (3.6 g).MS (m/z): 148 (MH+)1H-NMR (CDCl3) delta (ppm): 7.26-7.71 (1H, m), 7.75-7.82 (1H, m), 8.03 (1H, dd, J=1.2 Hz, J=8.4 Hz), 8.10 (1H, d, J=8.4 Hz), 8.38 (1H, s), 9.08 (1H, s), 1532-97-4

The synthetic route of 1532-97-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Asahi Kasei Pharma Corporation; US2010/93789; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-97-4,4-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

To a solution of 4-bromoisoquinoline (1 g, 4.80 mmol) in a solution of THF-diethyl ether (60 mL, 2:1) at -78 ¡ãC was added n-BuLi (2.5 M in THF, 3.8 mL, 9.62 mmol) dropwise and the mixture was allowed to stir at the same temperature for 1 h. To this solution was added a solution of DMF (0.9 mL, 12 mmol. 2.5 eq) in THF (5 mL) dropwise and the resulting mixture was allowed to stir at -78 ¡ãC for 2 h. Progress was monitored by TLC and LCMS. After completion,the reaction mixture was diluted with saturated, aqueous NH4C1 (50 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na2SO4 and filtered. Removal of solvent gave the crude product which was purified by CombiFlash to afford isoquinoline-4-carbaldehyde (553 mg, 73percent).LCMS: 158 [M+1], 1532-97-4

As the paragraph descriping shows that 1532-97-4 is playing an increasingly important role.

Reference£º
Patent; AURANSA INC.; PROTTER, Andrew, Asher; GREEN, Michael, John; CHANG, Hak, Jin; PHAM, Son, Minh; CHAKRAVARTY, Sarvajit; LUEDTKE, Gregory, R.; (254 pag.)WO2019/103897; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-97-4,4-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

To a solution of n-butyl lithium (133 mL, 332.5 mmol, 2.5 M in THF) in 760 mL THF was added a solution of 4-bromoisoquinoline 24a (20 g, 96.6 mmol) in 144 mL THF dropwise at -65¡ã C. and the resulting mixture was stirred at this temperature for another 30 mm after the completion of addition. A solution of N-fluorobenzenesulfonimide (66.68 g, 211.7 mmol) in 216 mL THF was added at -65¡ã C. in 1 h dropwisely. After being stirred for another 1 h at this temperature, the reaction mixture was warmed to room temperature slowly with stirring, after the reaction is over, 300 mL saturated aq. NH4Cl was added slowly, extracted with EtOAc (300 mL*3). The combined organic layers were washed with 300 mL brine, dried over anhydrous Na2SO4 and concentrated. The crude product was purified by silica gel column chromatography (0-100percent EtOAc/PE) to give 4-fluoroisoquinoline 24b (8.5 g, red oil, yield: 60percent).

1532-97-4 4-Bromoisoquinoline 73743, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; MEDSHINE DISCOVERY INC.; WU, Lingyun; YAO, Yuanshan; CHEN, Zhaoguo; CHEN, Shuhui; (69 pag.)US2017/37050; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1532-97-4, 4-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 4 This example illustrates the preparation of 4-bromo-5-nitro-isoquinoline having the formula: SPC9 4-bromo-isoquinoline (10.4 g) was dissolved in concentrated sulphuric acid (50 ml) and the solution was cooled to approximately 5¡ãC. A solution of potassium nitrate (8.6 g) in concentrated sulphuric acid (50 ml) was then added in dropwise fashion to maintain the temperature of the reaction mixture in the range 0¡ãC to 10¡ãC. After the addition was completed the reaction mixture was poured onto a mixture of ice (300 g) and water (300 ml), and ammonia was then slowly added until the mixture became alkaline. The reaction mixture was then filtered, and the yellow material thus isolated was washed with water and allowed to dry, to provide 9.0 g of 4-bromo-5-isoquinoline, melting at 177¡ã – 178¡ãC.

1532-97-4 4-Bromoisoquinoline 73743, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; ICI Australia Limited; US3930837; (1976); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem