Tag: 19493-45-9

19493-45-9, 3-Chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 60D 3-chloro-5-nitroisoquinoline The product from Example 60C (1.28 g, 7.85 mmol) in concentrated H2SO4 (30 mL) at 0 C. was treated with a solution of KNO3 (0.84 g, 8.32 mmol) in concentrated H2SO4 (5 mL) dropwise over 5 minutes. The mixture was stirred at 0 C. for 10 minutes, allowed to warm to room temperature, and stirred overnight. The mixture was poured onto 65 g of ice and the precipitated yellow solid was collected by filtration. The solid was slurried in water, collected by filtration, washed with water, and allowed to air-dry to provide the title compound as a pale yellow solid (0.45 g, 28%)., 19493-45-9

As the paragraph descriping shows that 19493-45-9 is playing an increasingly important role.

Reference£º
Patent; Abbott Laboratories; US6933311; (2005); B2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

19493-45-9, 3-Chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method AA Step 1 A mixture of F6 (20.0 mg, 0.049 mmol), Cul (3.7 mg, 0.019 mmol), 3- chloroisoquinoline (16.1 mg, 0.098 mmol), N,N-dimethylglycine (4.1 mg, 0.039 mmol) and Cs2C03 (35.2 mg, 0.108 mmol) in dioxane (3 mL) was stirred at 100 C for 14 h. The reaction mixture was quenched with water and extracted with EtOAc (15 mL x 4). The combined extracts were washed with brine (10 mL), dried over Na2S04, filtered and the filtrate was concentrated in vacuo. The residue was purified by p-HPLC (TFA condition) to give Example 77.

19493-45-9 3-Chloroisoquinoline 640968, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; CUMMING, Jared, N.; LIU, Hong; SCOTT, Jack, D.; (0 pag.)WO2016/85780; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19493-45-9,3-Chloroisoquinoline,as a common compound, the synthetic route is as follows.

EXAMPLE 2 3-(Piperazin-1-yl)-isoquinoline 2.0 g of 3-chloroisoquinoline are boiled under reflux for 120 hours with 20 g of piperazine in 100 ml of diethylene glycol dimethyl ether. Working up as in Example 1 gives 2.4 g of 3-(piperazin-1-yl)-isoquinoline, melting point 95-96; its hydrochloride decomposes at 266-268 C.

As the paragraph descriping shows that 19493-45-9 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US4590273; (1986); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

19493-45-9, 3-Chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 23 :3-(piperazin-l-yl)isoquinoline[00436] A mixture of 3-chloroisoquinoline (200 mg, 1.22 mmol) and piperazine (2.10 g, 24.4 mmol) in ethylene glycol (2 ml) was heated to 150C and stirred at that temperature for 24 hours. The reaction was allowed to cool down to room temperature. The crude mixture was partitioned between water and ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate, filtered and concentrated under vacuo. The residue was and purified on silica gel by flash column chromatography to give the title compound as a pale brown solid (131 mg, 50% yield).[00437 ] 1H NMR (CDCl3, 400 MHz) delta 3.18 (4H, t), 3.67 (4H, t), 6.81 (IH, s), 7.31 (IH, t), 7.54 (1 H, t), 7.62 (IH, d), 7.82 (IH, d), 8.97 (IH, s); MS (ES+) 214.

19493-45-9 3-Chloroisoquinoline 640968, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/94992; (2008); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem