Downstream synthetic route of 147497-32-3

As the paragraph descriping shows that 147497-32-3 is playing an increasingly important role.

147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the title A compound, 6-BROMO-3, 4-DIHYDRO-2H-ISOQUINOLIN-1-ONE (570 mg, 2.52 mmol) and benzyl bromide (390 UL, 3.28 mmol) in 10 mL of DMF is added sodium hydride (131 mg, 3.28 MMOL), and the reaction is stirred at RT for 3 h. The reaction is quenched with 1 N aqueous HCI, and the product is taken up in EtOAc. The organic solution is washed with water and brine, dried over anhydrous NA2SO4 and concentrated : Chromatography on silica (eluent : EtOAc/hexane – 1) affords 2-BENZYL-6-BROMO-3, 4-dihydro- 2H-isoquinolin-1-one.

As the paragraph descriping shows that 147497-32-3 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/65351; (2004); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem