Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.893566-75-1,Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.,893566-75-1

With N2 in dioxane (20 mL)8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester(R-1) (1100 mg, 3.52 mmol), NaI (4.76 g, 31.8 mmol),CuI (402 mg, 2.12 mmol) and trans-N,N-dimethylcyclohexaneThe mixture of (602 mg, 4.22 mmol) was purified for 10 minutes.The resulting yellow suspension was stirred in a sealed tube at 110¡ã C. for 48 hours. The reaction was diluted with petroleum ether (50 mL) and filtered.The filtrate was concentrated in vacuo and the residue was purified by tannin chromatography for petroleum etherThe EtOAC in (from 0 to 20percent) was purified by stripping to provide R-2 (1200 mg, 94.8percent) as a pale yellow gum.

As the paragraph descriping shows that 893566-75-1 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; KUMPF, ROBERT ARNOLD; MCALPINE, INDRAWAN JAMES; MCTIGUE, MICHELE ANN; PATMAN, RYAN; RUI, EUGENE YUANJIN; TATLOCK, JOHN HOWARD; TRAN-DUBE, MICHELLE BICH; WYTHES, MARTIN JAMES; (445 pag.)TW2018/2074; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

925672-85-1, 1,6-Dibromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,925672-85-1

Step 1 To a mixture of 1,6-dibromoisoquinolin-3-amine (XVIII)(0.5 g, 1.66 mmol), ammonium formate-d5 (0.56 g, 8.28 mmol)and Pd(PPh3)4 (191.3 mg, 0.170 mmol)in DMF (5 mL)was heated to 50 C. for 48 h. The solvents were concentrated and the residue was suspended in chloroform. The solid was collected by filtration and washed with water and EtOAc. The solid were dried under high vacuo to obtain 6-bromo-1-deuterio-isoquinolin-3-amine (XIX)(115 mg,0.513 mmol, 31.0% yield)as a pale yellow solid. 1H NMR (500 MHz, DMSO-d6)delta ppm 6.11 (2H, s), 6.55 (1H, s), 7.22 (1H, dd, J=8.78, 1.92 Hz), 7.73 (1H, d, J=8.51 Hz), 7.79 (1H, d, J=1.92 Hz); ESIMS found for C9H6DBrN2 m/z 224.0 (79BrM+H).

As the paragraph descriping shows that 925672-85-1 is playing an increasingly important role.

Reference£º
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Eastman, Brian Walter; Cao, Jianguo; Bollu, Venkataiah; Mittapalli, Gopi Kumar; Chiruta, Chandramouli; (218 pag.)US2017/313682; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

893566-75-1, Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,893566-75-1

Pd(OAc)2 (1.58 g, 7.05 mmol) was added to a mixture of intermediate 22 (22.00 g,70.47 mmol), DPPP (2.91 g, 7.05 mmol) and TEA (49.11 mL, 352.34 mmol) inMeOH/DMF solution (300 mL, 2:1, v/v). The resulting solution was stirred and pressurized to 40 psi with CO at 70 ¡ãC for 4 hours. The mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo.The crude residue was purified by column chromatography on silica gel (mobile phase gradient: from 91percent petroleum ether, 9percent EtOAc to 83percent petroleum ether, 17percent EtOAc) to give 12 g of intermediate 23 (59percent yield).

893566-75-1 Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate 59463272, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; PILATTE, Isabelle, Noelle, Constance; QUEROLLE, Olivier, Alexis, Georges; ANGIBAUD, Patrick, Rene; BERTHELOT, Didier, Jean-Claude; COUPA, Sophie; DEMESTRE, Christophe, Gabriel, Marcel; MEERPOEL, Lieven; MERCEY, Guillaume, Jean, Maurice; MEVELLEC, Laurence, Anne; MEYER, Christophe; PASQUIER, Elisabeth, Therese, Jeanne; PONCELET, Virginie, Sophie; (104 pag.)WO2017/216293; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

925672-85-1, 1,6-Dibromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,925672-85-1

To a mixture of 1,6-dibromoisoquinolin-3-amine (XIII) (0.5 g, 1.66 mmol), ammonium formate-d5 (0.56 g, 8.28 mmol) and Pd(PPh3)4(191.3 mg, 0.170 mmol) in DMF (5 mL) was heated to 50 C. for 48 h. The solvents were concentrated and the residue was suspended in chloroform. The solid was collected by filtration and washed with water and EtOAc. The solid were dried under high vacuo to obtain 6-bromo-1-deuterio-isoquinolin-3-amine (XIV) (115 mg, 0.513 mmol, 31.0% yield) as a pale yellow solid. 1H NMR (500 MHz, DMSO-d6) delta ppm 6.11 (2H, s), 6.55 (1H, s), 7.22 (1H, dd, J=8.78, 1.92 Hz), 7.73 (1H, d, J=8.51 Hz), 7.79 (1H, d, J=1.92 Hz); ESIMS found for C9H6DBrN2 m/z 224.0 (79BrM+H).

925672-85-1 1,6-Dibromoisoquinolin-3-amine 16049917, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Hofilena, Brian Joseph; Mittapalli, Gopi Kumar; Eastman, Brian Walter; Cao, Jianguo; Bollu, Venkataiah; Chiruta, Chandramouli; (149 pag.)US2019/125740; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem