893566-75-1, Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,893566-75-1
Pd(OAc)2 (1.58 g, 7.05 mmol) was added to a mixture of intermediate 22 (22.00 g,70.47 mmol), DPPP (2.91 g, 7.05 mmol) and TEA (49.11 mL, 352.34 mmol) inMeOH/DMF solution (300 mL, 2:1, v/v). The resulting solution was stirred and pressurized to 40 psi with CO at 70 ¡ãC for 4 hours. The mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo.The crude residue was purified by column chromatography on silica gel (mobile phase gradient: from 91percent petroleum ether, 9percent EtOAc to 83percent petroleum ether, 17percent EtOAc) to give 12 g of intermediate 23 (59percent yield).
893566-75-1 Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate 59463272, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; PILATTE, Isabelle, Noelle, Constance; QUEROLLE, Olivier, Alexis, Georges; ANGIBAUD, Patrick, Rene; BERTHELOT, Didier, Jean-Claude; COUPA, Sophie; DEMESTRE, Christophe, Gabriel, Marcel; MEERPOEL, Lieven; MERCEY, Guillaume, Jean, Maurice; MEVELLEC, Laurence, Anne; MEYER, Christophe; PASQUIER, Elisabeth, Therese, Jeanne; PONCELET, Virginie, Sophie; (104 pag.)WO2017/216293; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem