214045-86-0, 1-Chloro-6-fluoroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Following the same LDA deprotonation protocol (preparation of Example 203) of 1- chloro-6-fluoro isoquinoline described previously, the initial anion was quenched with 2-thiophenecarboxaldehyde instead, to give 1-chloro-6-fluoro isoquinolin-5-yl-thiophen-2-yl-methanol. The material was oxidized to the 1-chloro-6-fluoro- isoquinolin-5-yl-thiophen-2-yl-methanone usingMn02 in benzene in 49.6% overall yield after chromatographic purification. LC/MS rt-min(MH) [method C]: 2.98(292).’H NMR (400 MHz, CHLOROFORM-D)8 ppm 7.12 (dd, J=4. 89,3. 91 Hz,1 H) 7.40 (m,1 H) 7.53 (m, 1 H) 7.56 (dd, J=5. 87,0. 73 Hz,1 H) 7.82 (dd, J=5.01, 1.10 Hz,1 H) 8.27 (d, J=5. 87 Hz,1 H) 8.54 (ddd, J=9. 29,5. 38,0. 73 Hz,1 H). Ipso nucleophilic aromatic displacement of the fluorine atom was accomplished in a solution of excess of potassium methoxide to give, mainly 1-chloro-6-methoxy- isoquinolin-5-yl-thiophen-2-yl-methanone along with 25-33% of 1,6-dimethoxy- isoquinolin-5-yl-thiophen-2-yl-methanone. The crude material (77mg) was used in the alkylation step with the tripeptide without further purification., 214045-86-0
The synthetic route of 214045-86-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99274; (2003); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem