925672-85-1, 1,6-Dibromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,925672-85-1
Step 1 To a mixture of 1,6-dibromoisoquinolin-3-amine (XVIII)(0.5 g, 1.66 mmol), ammonium formate-d5 (0.56 g, 8.28 mmol)and Pd(PPh3)4 (191.3 mg, 0.170 mmol)in DMF (5 mL)was heated to 50 C. for 48 h. The solvents were concentrated and the residue was suspended in chloroform. The solid was collected by filtration and washed with water and EtOAc. The solid were dried under high vacuo to obtain 6-bromo-1-deuterio-isoquinolin-3-amine (XIX)(115 mg,0.513 mmol, 31.0% yield)as a pale yellow solid. 1H NMR (500 MHz, DMSO-d6)delta ppm 6.11 (2H, s), 6.55 (1H, s), 7.22 (1H, dd, J=8.78, 1.92 Hz), 7.73 (1H, d, J=8.51 Hz), 7.79 (1H, d, J=1.92 Hz); ESIMS found for C9H6DBrN2 m/z 224.0 (79BrM+H).
As the paragraph descriping shows that 925672-85-1 is playing an increasingly important role.
Reference£º
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Eastman, Brian Walter; Cao, Jianguo; Bollu, Venkataiah; Mittapalli, Gopi Kumar; Chiruta, Chandramouli; (218 pag.)US2017/313682; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem