With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.
2) In 1000 L in the reactor are separately put into dichloromethane 500 L, homopiperazine 50 kg and liquid ammonia 33 kg, stirring solution cleaning, adding step 1) obtained FZ010 – 1. In the 10 C insulation reaction to the TLC detection without FZ010 – 1 residue when the end of the reaction, the reaction time is 2 – 4 H-. The reaction […] purified water 300 L, stir, fully after standing, divide the methylene chloride level. The aqueous layer then 100 L methylene chloride extraction, repeating the extraction of two, then the collection of methylene chloride level; to-methylene chloride layer in purified water 300 L, dropwise 4 mol/L hydrochloric acid solution to adjust system for pH 4.5 – 5.0, during the dropping temperature of not higher than 40 C, layered; collecting water layer, mass fraction of 20% NaOH solution to adjust the pH of the aqueous layer to 8.0, during the dropping temperature of not higher than 40 C. For 200 L methylene chloride extraction, repeating the extraction of 3 times, then the collection of methylene chloride level, vacuum distillation, to obtain yellowish sticks the thick oil objects, about 21.8 kg, is the intermediate hexahydro -1 – (5 – isoquinoline sulfonyl) – 1 H – 1, 4 – benzodiazepine salt (formula (I) in the FZ010 – 2), yield is 54.5%.
105627-79-0, As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.
Reference£º
Patent; Henan Runhong Pharmaceutical Co., Ltd.; Cui Hailong; Ma Liyan; Wang Xiaoxue; Shi Yongzhi; An Xiaomin; Shi Huifeng; Zhang Wei; (8 pag.)CN109574992; (2019); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem