Category: 104-01-8

Chen, Wenjun published the artcileSynthesis of benzo[4,5]imidazo[1,2-a]quinoxalines by I2-mediated sp3 C-H amination, Category: isoquinoline, the main research area is benzoimidazoquinoxaline preparation; benzoimidazolyl aniline iodine amination.

Benzo[4,5]imidazo[1,2-a]quinoxaline derivatives were synthesized from readily accessible 2-(benzoimidazol-1-yl)aniline substrates by an I2-mediated direct sp3 C-H amination reaction. This synthetic strategy did not use transition-metals, is operationally simple scalable and gives high yields.

Organic Chemistry Frontiers published new progress about Amination. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Svec, Riley L. published the artcileImidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations, Safety of 4-Methoxyphenylacetic acid, the main research area is repurpose imidazotetrazine weighable diazomethane synthon esterification cyclopropanation; alkylation; cyclopropanation; diazo compounds; diazomethane; imidazotetrazines.

Diazomethane is one of the most versatile reagents in organic synthesis, but its utility is limited by its hazardous nature. Although alternative methods exist to perform the unique chem. of diazomethane, these suffer from diminished reactivity and/or correspondingly harsher conditions. Herein, we describe the repurposing of imidazotetrazines (such as temozolomide, TMZ, the standard of care for glioblastoma) for use as synthetic precursors of alkyl diazonium reagents. TMZ was employed to conduct esterifications and metal-catalyzed cyclopropanations, and results show that Me ester formation from a wide variety of substrates is especially efficient and operationally simple. TMZ is a com. available solid that is non-explosive and non-toxic, and should find broad utility as a replacement for diazomethane.

Angewandte Chemie, International Edition published new progress about Alkylation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ma, Pengju published the artcilePhotocatalyst- and additive-free decarboxylative alkylation of N-aryl tetrahydroisoquinolines induced by visible light, Formula: C9H10O3, the main research area is alkyl aryl tetrahydroisoquinoline preparation; tetrachlorohydroxyphthalimide alkyl ester aryl tetrahydroisoquinoline decarboxylative alkylation.

Synthesis of C-1 alkylated tetrahydroisoquinoline products I (R = Pr, 4-oxocyclohexyl, oxan-4-yl, etc.; R1 = Ph, pyridin-4-yl, naphthalen-1-yl, etc.; R2 = H. MeO) and II via a visible light induced decarboxylative alkylation of N-aryl tetrahydroisoquinolines III (X = H) and 9-methyl-2-phenyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indole has been developed using tetrachloro-N-hydroxyphthalimide esters IV as alkylation agents. This redox-neutral reaction can proceed without the assistance of photocatalysts, transition metals and external additives by irradiation with blue LEDs. Preliminary mechanistic studies indicated that this transformation probably proceeded through an electron donor-acceptor complex involved radical process.

Organic Chemistry Frontiers published new progress about Alkylation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cannalire, Rolando published the artcileBroad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions, Application of 4-Methoxyphenylacetic acid, the main research area is dengue yellow fever virus antiflavivirus pyridobenzothiazolone; Antiviral small molecules; Antivirals; Dengue inhibitors; Flavivirus inhibitors; Flavivirus replication; Zika virus.

We report the design, synthesis, and biol. evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low μM range with reasonable selectivity against Dengue 2, Yellow fever (Bolivia strain), and West Nile viruses. One of the most interesting mols., compound 16, showed broad antiviral activity against addnl. flaviviruses such as Dengue 1, 3 and 4, Zika, Japanese encephalitis, several strains of Yellow fever, and tick-borne encephalitis viruses. Compound 16 did not exert any effect on alphaviruses and phleboviruses and its activity was maintained in YFV infected cells from different species. The activity of 16 appears specific for flavivirus with respect to other virus families, suggesting, but not proving, that it might be targeting a viral factor. We demonstrated that the antiviral effect of 16 is not related to reduced viral RNA synthesis or virion release. On the contrary, viral particles grown in the presence of 16 showed reduced infectivity, being unable to perform a second round of infection. The chem. class herein presented thus emerges as suitable to provide pan-flavivirus inhibitors.

Antiviral Research published new progress about Alphavirus. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Arendowski, Adrian published the artcileScreening of urinary renal cancer metabolic biomarkers with gold nanoparticles-assisted laser desorption/ionization mass spectrometry, Computed Properties of 104-01-8, the main research area is gold nanoparticle metabolic biomarker laser desorption ionization mass spectrometry.

Renal cell carcinoma is a very aggressive and often fatal disease for which there are no specific biomarkers found to date. The purpose of this work was to find features that differentiate urine metabolic profiles of healthy people and cancer patients. Laser desorption/ionization mass spectrometry on gold nanostructures-based techniques were used for the metabolic anal. of urine of 50 patients with kidney cancer. Comparison with data from 50 healthy volunteers led to the discovery of several compounds that may be considered potential renal cell carcinoma (RCC) biomarkers. Statistical anal. of data allowed for the discovery of m/z values that had the greatest impact on group differentiation. A database search enabled the assignment of signals for the most promising 15 features among them: serine, heptanol, 3-methyleneindolenine, 2-methyl-3-hydroxy-5-formylpyridine-4-carboxylate, phosphodimethylethanolamine, 4-methoxyphenylacetic acid, N-acetylglutamine, 3,5-dihydroxyphenylvaleric acid, hydroxyhexanoylglycine, valyl-leucine, leucyl-histidine, oleamide, 9,12,13-trihydroxyoctadecenoic acid, stearidonyl carnitine and squalene. Differences of metabolite profiles of human urine could be identified by gold nanoparticle-enhanced target (AuNPET) LDI MS method and used for the detection of renal cancer.

Analytical Sciences published new progress about Biomarkers. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Jiacheng published the artcileMinisci-Type Alkylation of N-Heteroarenes by N-(Acyloxy)phthalimide Esters Mediated by a Hantzsch Ester and Blue LED Light, Application In Synthesis of 104-01-8, the main research area is alkylated quinoline preparation; quinoline acyloxy phthalimide ester Minisci type alkylation HE mediated; isoquinoline alkylated preparation; acyloxy phthalimide ester isoquinoline Minisci type alkylation HE mediated; pyridine alkylated preparation; phthalimide ester acyloxy pyridine Minisci type alkylation HE mediated.

A synthetic method that enabled the Hantzsch ester (HE)-mediated Minisci-type C2-alkylation of quinolines, isoquinolines and pyridines by N-(acyloxy)phthalimide esters (NHPI) to afford alkylated N-heterocyclic products, e.g., I, under blue LED (light emitting diode) light (456 nm) was described. Achieved under mild reaction conditions at room temperature, the metal-free synthetic protocol was shown to be applicable to primary, secondary and tertiary NHPIs to give the alkylated N-heterocyclic products in yields of 21-99%. On introducing a chiral phosphoric acid, an asym. version of the reaction was also realized and provided product enantiomeric excess (ee) values of 53-99%.

Advanced Synthesis & Catalysis published new progress about Alkylation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Navale, Balu S. published the artcilePropargyl α-aryl-α-diazoacetates as robust reagents for the effective C-H bond functionalization of 1,3-diketones via scandium catalysis, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is propargyl aryl dicarbonyl compound preparation; diketone propargyl aryl diazoacetate alkylation scandium catalyst.

Propargyl α-aryl-α-diazoacetates RC(=N2)C(O)OCH2CCH [R = 4-ClC6H4, naphthalen-2-yl, 3,4-(H3CO)2C6H3, etc.] a new class of reagents is developed for the effective C-H bond functionalization of 1,3-diketones R1C(O)CH2C(O)R1 (R1 = Me, Et, Ph, 4-H3CC6H4, 4-H3COC6H4) at room temperature The combination of scandium triflate and propargyl α-aryl-α-diazoacetates proved to be efficient catalyst-reagent system for the controlled C-H bond functionalization to afford 1,3-dicarbonyl alkylation products RCH(CH(C(O)R1)2)C(O)OCH2CCH. The protocol uses inexpensive Sc(OTf)3 (5 mol%) and the reaction did not require the use of expensive catalysts or ligands and worked efficiently at room temperature The practicality of the protocol has been demonstrated by the gram scale synthesis.

Tetrahedron Letters published new progress about Alkylation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Yanqin published the artcileEffects of N-, P-, or O-containing ligands on gold-based complex catalysts for acetylene hydrochlorination, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is acetylene hydrochlorination nitrogen phosphorus oxygen ligand gold complex catalyst.

In line with the fulfillment of international Minamata Convention and the urgent need for developing non-mercury catalysts, Au-Lx/AC catalysts were synthesized and evaluated for the hydrochlorination of acetylene. The results showed that the interaction between ligands and Au species contributed to the enhanced catalytic activity with important and different roles of each ligand. Depending on the high electronegativity of heteroatoms, all the prepared catalysts had effectively improved their adsorption and activation capacity of hydrogen chloride. Specifically, the N-containing ligands in catalysts increased the dispersion of Au species and an enhanced adsorption of acetylene was observed While, the coordination of P-containing ligands with Au can increase the relative content of active Aun+ species and the O-containing ligands rather decreased the adsorption of acetylene. Furthermore, all the prepared Au-Lx/AC catalysts showed good stabilities based on the inhibition of the agglomeration of Au components or of coking deposition.

Applied Catalysis, A: General published new progress about Adsorption. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chiang, Chao-Lung published the artcileEnhancement of CO2 adsorption and separation for non-porous Zn/Co azolate frameworks via ethanol-induced structural transformation, Application In Synthesis of 104-01-8, the main research area is carbon dioxide zinc cobalt azolate adsorption separation.

Non-porous zinc/cobalt azolate frameworks with diamond-type crystal structure (MAF-31/ZIF-D-CoM) have been synthesized in large scale with an acid-catalyzed process. Afterward, an ethanol exposure process was applied for 1, 7, and 14 days to transform MAF-31/ZIF-D-CoM into porous T-MAF-4/T-ZIF-67. Two porous zinc/cobalt azolate frameworks standards (MAF-4/ZIF-67) with sodalite-type crystal structures were prepared with a solvent-free method for comparison with T-MAF-4/T-ZIF-67. Effects of ethanol vapor exposure on structual transformation of MAF-31/ZIF-D-CoM were characterized throughly. Obvious structural transfomations between non-porous and porous zinc/cobalt azolate frameworks were found with X-ray diffraction (XRD), Field-emission scanning electron microscope (FE-SEM), and X-ray absorption near-edge structure/extended X-ray absorption fine structure (XANES/EXAFS) spectra. After the 14-day ethanol vapor exposure, the CO2 adsorption uptakes of MAF-31 and ZIF-D-CoM in low/high pressures were enhanced from 5.18 × 10-5/0.68 and 1.20 × 10-4/0.18 to 1.76 × 10-3/8.27 and 1.99 × 10-3/11.2 mmol/g, resp. The CO2 selectivities of MAF-31/ZIF-D-CoM were also improved from 0.29/2.34 to 6.33/16.47. In addition, CO2 adsorption over zinc/cobalt azolate frameworks obeyed both Langmuir/Freundlich adsorption isotherm models with good agreements.

Journal of the Taiwan Institute of Chemical Engineers published new progress about Adsorption. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kumar, Jagdeep published the artcileOptical properties of 3-substituted indoles, Formula: C9H10O3, the main research area is phenyl ethenylindole preparation diastereoselective DFT optical property; formylindole phenyl acetic acid condensation.

The optical properties of various donor or acceptor p-Ph substituted ethenyl indoles I (R = H, OH, Cl, etc.; R1 = H, Et, acetyl, benzenesulfonyl) were studied in solvents of varying polarity using absorption, fluorescence and TDDFT methods. Ethenyl indole exhibits non-linear optical properties (NLO) in a substituent dependent manner. Compound with a strong electron-attracting substituent-, shows large NLO properties with charge transfer behavior, whereas ethenyls with moderate electron withdrawing or electron donating substituent exhibit lower NLO properties with non polar excited state. A highly dipolar excited state for p-nitro Ph substituted ethenyl indoles (μe: 18.2-27.1 debye; Δμ: 9.4-17.8 debye) is observed as compared to other ethenyls (μe: 6.6-9.5 debye; Δμ: 4.2-6.2 debye). From TDDFT study, it is shown that the HOMO-LUMO energy of ethenyl is increased with increasing the electron donating ability of the p-Ph substitution. The optical band gap of ethenyl I (R = R1 = H, II) without substitution, is decreased upon p-Ph substitution either with an electron withdrawing (Cl, NO2) or an electron donating (OCH3, OH, NH2) substituent. The compound with a strong electron accepting, p-nitrophenyl ethenyl indole I (R = NO2, R1 = H, III) shows 12 times better NLO response as compared to the reference ethenyl indole II (β: III: 115 x 10-30 esu-1 cm5, II: 9 x 10-30 esu-1 cm5). Ethenyls I (R = Cl, H, OMe, OH, NH2; R1 = H) bearing a weak or moderately electron withdrawing or electron accepting substituent, exhibit lower NLO response. The β of ethenyl is increased with increasing the order of electron withdrawing nature of Ph ring. Overall, a correlation of β with the optical band gap, ground state dipole moment, % of charge transfer in the ground and excited state is found.

RSC Advances published new progress about Absorption. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem