Category: 104-01-8

Shi, Jiale published the artcileMetal-Free Heterogeneous Semiconductor for Visible-Light Photocatalytic Decarboxylation of Carboxylic Acids, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is aliphatic hetero aromatic arene preparation; hetero aromatic aliphatic acid hydrodecarboxylation photocatalyst; deuteride aliphatic hetero aromatic arene preparation; aromatic hetero aliphatic acid decarboxylative deuteration photocatalyst; diaryl methane preparation; carboxylic acid hetero aryl cyanide decarboxylative arylation photocatalyst.

A suitable protocol for the photocatalytic decarboxylation of carboxylic acids RC(O)OH (R = 3,5-dimethylphenyl, 2-(4-methylphenyl)ethyl, diphenylmethyl, isoquinolin-1-yl, etc.) was developed with metal-free ceramic boron carbon nitrides (BCN). With visible light irradiation, BCN oxidizes carboxylic acids to give carbon-centered radicals, which were trapped by hydrogen atom donors or employed in the construction of the carbon-carbon bond. In this system, both (hetero)aromatic and aliphatic acids proceed through the decarboxylation smoothly; and C-H, C-D, and C-C bonds are formed in moderate to high yields (35 examples, yield up to 93%). Control experiments support a radical process, and isotopic experiments show that methanol is employed as the hydrogen atom donor. Recycling tests and a gram-scale reaction elucidate the practicability of the heterogeneous ceramic BCN photoredox system. It provides an alternative to homogeneous catalysts in the valuable carbon radical intermediates formation. Moreover, the metal-free system is also applicable to late-stage functionalization of anti-inflammatory drugs, such as naproxen and ibuprofen, which enrich the chem. toolbox.

ACS Catalysis published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shen, Zhenpeng published the artcileIron-Promoted Decarboxylation of Arylacetic Acids for the Synthesis of Aromatic Nitriles with Sodium Nitrite as the Nitrogen Source, Product Details of C9H10O3, the main research area is aromatic nitrile preparation; arylacetic acid decarboxylation iron catalyst.

A new and effective method was developed for the synthesis of aromatic nitriles ArCN (Ar = 4-chlorophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) (I) from arylacetic acids ArCH2C(O)OH (II) by using NaNO2 as the nitrogen source and Fe(OTf)3 as the promoter at 50°C. A series of arylacetic acids II underwent this transformation to give the targeted products I in yields of 51-90%. Because of the mild conditions, the reaction is compatible with a broad range of functional groups, including ester, carboxy, hydroxy, acetamido, halo, nitro, cyano, methoxy, and even highly reactive formyl groups.

Synlett published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Rahman, Taskia published the artcileSpinel Structured Copper Ferrite Nano Catalyst with Magnetic Recyclability for Oxidative Decarboxylation of Phenyl Acetic Acids, Related Products of isoquinoline, the main research area is copper ferrite catalyst oxidative decarboxylation phenyl acetic acid.

A simple, efficient and environmentally benign method has been discussed for the synthesis of aldehydes and ketones by the oxidative decarboxylation of phenylacetic acid under ligand free condition using simple, efficient, preparatively easy, magnetically recoverable and low cost spinel CuFe2O4 nanoparticles. The catalyst was characterized using powder-XRD, FTIR, FE-SEM, EDX, VSM and HRTEM. The recyclability was examined and the results showed that the catalyst remained almost equally active up to five consecutive cycles. Spinel Structured Copper Ferrite is a very efficient nano catalyst for Oxidative decarboxylation of Ph acetic acids and can be reused up to five cycles without significant loss in catalytic activity.

Catalysis Letters published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Song, Changhua published the artcileRegio- and Enantioselective Decarboxylative Allylic Benzylation Enabled by Dual Palladium/Photoredox Catalysis, Related Products of isoquinoline, the main research area is chiral homoallylic alc preparation regioselective enantioselective; allylic acetate phenylacetic acid vinylepoxide decarboxylative benzylation photoredox palladium.

A decarboxylative allylic benzylation cocatalyzed by Pd/photoredox in a regio- and enantioselective manner has been achieved. Readily available aryl acetic acids are used as benzylic nucleophile equivalent without preactivation. This mild and atom economic protocol expands the scope of coupling partners of allylic electrophiles. Vinyl epoxides could also go through this transformation smoothly, affording various chiral homoallylic alcs. bearing all-carbon quaternary stereocenters.

ACS Catalysis published new progress about Alcohols, homoallylic Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Murakami, Hiroki published the artcileNovel Aza-Michael Addition-Asymmetric Protonation to α,β-Unsaturated Carboxylic Acids with Chiral Thiourea-Boronic Acid Hybrid Catalysts, Synthetic Route of 104-01-8, the main research area is propenoic acid hydroxylamine chiral thiourea tandem aza Michael protonation; hydroxyamino propanoic acid preparation enantioselective.

In this study, an efficient method was developed for controlling carbonyl α-chirality with functionalizing β-position by the conjugate addition-asym. protonation (CAAP) of α,β-unsaturated carboxylic acids using chiral thiourea-amino boronic acid hybrid catalysts. In addition, the method was applied to the asym. synthesis of biol. active compounds

Asian Journal of Organic Chemistry published new progress about Aliphatic amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kaal, Joeri published the artcileOrigin of dissolved organic matter in the Harz Mountains (Germany): A thermally assisted hydrolysis and methylation (THM-GC-MS) study, Related Products of isoquinoline, the main research area is dissolved organic matter thermally assisted hydrolysis and methylation Germany.

Environmental change is increasing the concentration of dissolved organic matter (DOM) in catchments of the Northern Hemisphere. This study aims to assess the causes of high DOM concentrations in streams and reservoirs of the Harz National Park (Germany), by means of mol. characterization using thermally assisted hydrolysis and methylation (THM-GC-MS). In order to formulate proxies of the prevailing origin of the numerous THM products of polyphenols, carbohydrates, proteins, aliphatic macromols., resins and other DOM precursors, we created a reference sample set of potential sources (spruce, birch, blueberry, heather, peat moss, soils) from the area. THM compounds that tend to be more abundant in WEOM than in BOM are G-type phenolic compounds (1,2-dimethoxybenzenes, from lignin and tannin), nitrogen-containing moieties and benzene carboxylic acids, whereas WEOM is depleted in products of polysaccharides, syringyl lignin and aliphatic macromols. (cutin and suberin). The lignin fingerprint of the WEOM also differs significantly from that of BOM, being depleted in the vast majority of the typical products of macromol. lignin (G7, G8, G14, G15) and enriched in the acid moiety (G6, predominantly from vanillic acid), especially for spruce wood. This may indicate a major role of DOM released from decaying spruce logs and forest soils. The results highlight both the potential and the pitfalls associated with source identification of DOM using THM-GC-MS.

Geoderma published new progress about Anisoles Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Yang published the artcileStructure-activity relationship study of DEL-22379: ERK dimerization inhibitors with increased safety, Synthetic Route of 104-01-8, the main research area is lung liver cancer DEL22379 anticancer agent ERK signaling; Anti-cancer activity; ERK dimerization inhibitor; Indolin-2-one; Structure–activity relationship; Synthesis.

Abstract: Aberrant activation of ERK signaling pathway usually leads to oncogenesis, and small mol. agents targeting this pathway are impeded by the emergence of drug resistance due to reactivation of ERK signaling. Compound DEL-22379 has been reported to inhibit ERK dimerization which was unaffected by drug-resistant mechanism reactivating the ERK signaling. Here, we discussed a structure-activity relationship study of DEL-22379. Forty-seven analogs were designed and synthesized. Each synthesized compound was biol. evaluated for their inhibitory rates on several tumor cell lines and compounds with high inhibitory rates were further evaluated for IC50 values. The structure-activity relationship of idolin-2-one scaffold and the impact of Z/E configuration on potency were discussed. Potential safety of two synthesized analogs was investigated and in silico docking study of five compounds was performed to understand the structural basis of ERK dimerization inhibition. Graphic abstract: [graphic not available: see fulltext].

Molecular Diversity published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bazzi, Sakna published the artcileElectrogenerated Sm(II)-Catalyzed CO2 Activation for Carboxylation of Benzyl Halides, Category: isoquinoline, the main research area is phenylacetic acid preparation; benzyl halide carbon dioxide reductive electrochem carboxylation samarium catalyst.

Sm(II)-catalyzed carboxylation of benzyl halides is reported through the electrochem. reduction of CO2. The transformation proceeds under mild reaction conditions to afford the corresponding phenylacetic acids in good to excellent yields. This user-friendly and operationally simple protocol represents an alternative to traditional strategies, which usually proceeds through the C(sp3)-halide activation pathway.

Organic Letters published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wei, Duo published the artcileRhenium-Catalyzed Reduction of Carboxylic Acids with Hydrosilanes, Computed Properties of 104-01-8, the main research area is rhenium catalyzed photochem reduction carboxylic acid hydrosilane; disilylacetal preparation; aldehyde preparation.

Re2(CO)10 efficiently catalyzes the direct reduction of various carboxylic acids under mild conditions (rt, irradiation 350 or 395 nm). While aliphatic carboxylic acids were readily converted to the corresponding disilylacetals with low catalyst loading (0.5 mol %) in the presence of Et3SiH (2.2 equiv), aromatic analogs required more drastic conditions (Re2(CO)10 5 mol %, Ph2MeSiH 4.0 equiv) to afford the corresponding aldehydes after acid treatment.

Organic Letters published new progress about Acetals Role: SPN (Synthetic Preparation), PREP (Preparation) (disilylacetals). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ishihara, Kazuaki published the artcileEnantio- and Site-Selective α-Fluorination of N-Acyl 3,5-Dimethylpyrazoles Catalyzed by Chiral π-CuII Complexes, Safety of 4-Methoxyphenylacetic acid, the main research area is enantioselective regioselective fluorination acyldimethylpyrazole chiral pi copper complex; asymmetric catalysis; copper; fluorination; pyrazoles; π-cation interactions.

Catalytic enantioselective α-fluorination reactions of carbonyl compounds are among the most powerful and efficient synthetic methods for constructing optically active α-fluorinated carbonyl compounds Nevertheless, α-fluorination of α-nonbranched carboxylic acid derivatives is still a big challenge because of relatively high pKa values of their α-hydrogen atoms and difficulty of subsequent synthetic transformation without epimerization. Herein we show that chiral copper(II) complexes of 3-(2-naphthyl)-L-alanine-derived amides are highly effective catalysts for the enantio- and site-selective α-fluorination of N-(α-arylacetyl) and N-(α-alkylacetyl) 3,5-dimethylpyrazoles [e.g., I → II (99%, 91% ee)]. The substrate scope of the transformation is very broad (25 examples including a quaternary α-fluorinated α-amino acid derivative). α. α-Fluorinated products were converted into the corresponding esters, secondary amides, tertiary amides, ketones, and alcs. with almost no epimerization in high yield.

Angewandte Chemie, International Edition published new progress about Acidity (LFER for acidity of N-acylpyrazoles vs. mol. electrostatic potential). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem