Category: 1455-77-2

Pismataro, Maria Chiara published the artcile1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors, Safety of 3,5-Diamino-1,2,4-triazole, the main research area is triazolopyrimidine preparation antiviral influenza polymerase PA PB1 interaction disruptor; 1,2,4-triazolo[1,5-a]pyrimidines; Antiviral agents; Influenza polymerase; Influenza virus; PA-PB1 interaction; Protein-protein interaction; SARS-CoV-2.

In the search for new anti-influenza virus (IV) compounds, the 1,2,4-triazolo[1,5-a]pyrimidine (TZP) was identified as a very suitable scaffold to obtain compounds able to disrupt IV RNA-dependent RNA polymerase (RdRP) PA-PB1 subunits heterodimerization. To this aim, four facile and efficient one-step procedures for the synthesis of 5-phenyl-, 6-phenyl- and 7-phenyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidines, and 2-amino-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol has been developed. Two analogs having the Et carboxylate moiety at the C-2 position of the TZP were also prepared in good yields. Then, the scaffolds herein synthesized and two previous scaffolds were functionalized and evaluated for their anti-IAV activity, leading to the identification of compound 2-(5-Methyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-4H-benzo[d][1,3]oxazin-4-one that showed both anti-PA-PB1 (IC50 = 19.5μM) and anti-IAV activity (EC50 = 16μM) at non-toxic concentrations, thus resulting among the most active TZP derivatives reported to date by us. A selection of the synthesized compounds, along with a set of inhouse available analogs, was also tested against SARS-CoV-2. The most promising compound N-(2-Fluorophenyl)-7-methyl-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide from this series displayed an EC50 value of 34.47μM, highlighting the potential of the TPZ scaffold in the search for anti-CoV agents.

European Journal of Medicinal Chemistry published new progress about Antiviral agents. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Safety of 3,5-Diamino-1,2,4-triazole.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pismataro, Maria Chiara published the artcile1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors, HPLC of Formula: 1455-77-2, the main research area is triazolopyrimidine preparation antiviral influenza polymerase PA PB1 interaction disruptor; 1,2,4-triazolo[1,5-a]pyrimidines; Antiviral agents; Influenza polymerase; Influenza virus; PA-PB1 interaction; Protein-protein interaction; SARS-CoV-2.

In the search for new anti-influenza virus (IV) compounds, the 1,2,4-triazolo[1,5-a]pyrimidine (TZP) was identified as a very suitable scaffold to obtain compounds able to disrupt IV RNA-dependent RNA polymerase (RdRP) PA-PB1 subunits heterodimerization. To this aim, four facile and efficient one-step procedures for the synthesis of 5-phenyl-, 6-phenyl- and 7-phenyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidines, and 2-amino-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol has been developed. Two analogs having the Et carboxylate moiety at the C-2 position of the TZP were also prepared in good yields. Then, the scaffolds herein synthesized and two previous scaffolds were functionalized and evaluated for their anti-IAV activity, leading to the identification of compound 2-(5-Methyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-4H-benzo[d][1,3]oxazin-4-one that showed both anti-PA-PB1 (IC50 = 19.5μM) and anti-IAV activity (EC50 = 16μM) at non-toxic concentrations, thus resulting among the most active TZP derivatives reported to date by us. A selection of the synthesized compounds, along with a set of inhouse available analogs, was also tested against SARS-CoV-2. The most promising compound N-(2-Fluorophenyl)-7-methyl-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide from this series displayed an EC50 value of 34.47μM, highlighting the potential of the TPZ scaffold in the search for anti-CoV agents.

European Journal of Medicinal Chemistry published new progress about Antiviral agents. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, HPLC of Formula: 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wu, Yunling published the artcile2D molecular sheets of hydrogen-bonded organic frameworks for ultrastable sodium-ion storage, Synthetic Route of 1455-77-2, the main research area is hydrogen bonded organic framework sodium ion secondary battery; chemical stability; hydrogen-bonded organic frameworks; molecular sheets; multi-site hydrogen bonds; sodium ion storage.

There has been growing research interest in hydrogen bonded organic frameworks (HOFs) by virtue of their great structural crystallinity, large surface areas and porosity. Their potential in electrochem. applications, unfortunately, remains elusive because weak hydrogen bonds would dissociate in solution that eventually compromises the structural integrity. Herein, it is demonstrated that this issue may be overcome by designing and introducing multisite hydrogen bonding within HOFs. 2D mol. sheets are prepared using diaminotriazole as the linkers for the first time. In spite of the mol. thickness (≈1 nm), they are chem. stable and mech. robust, and have diminished solubility in most polar or nonpolar organic solvents. This solution-stable HOF exhibits an excellent electrochem. performance for Na+ ion storage. In particular, it enables an exceptional cycle life of >10 000 cycles at 1 A g-1, which is far superior to most other organic electrode materials. Theor. simulations indicate that the activation barrier for the intralayer or interlayer diffusion of Na+ ions within the organic frameworks is small.

Advanced Materials (Weinheim, Germany) published new progress about Battery cathodes. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Synthetic Route of 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wu, Yunling published the artcile2D molecular sheets of hydrogen-bonded organic frameworks for ultrastable sodium-ion storage, Synthetic Route of 1455-77-2, the main research area is hydrogen bonded organic framework sodium ion secondary battery; chemical stability; hydrogen-bonded organic frameworks; molecular sheets; multi-site hydrogen bonds; sodium ion storage.

There has been growing research interest in hydrogen bonded organic frameworks (HOFs) by virtue of their great structural crystallinity, large surface areas and porosity. Their potential in electrochem. applications, unfortunately, remains elusive because weak hydrogen bonds would dissociate in solution that eventually compromises the structural integrity. Herein, it is demonstrated that this issue may be overcome by designing and introducing multisite hydrogen bonding within HOFs. 2D mol. sheets are prepared using diaminotriazole as the linkers for the first time. In spite of the mol. thickness (≈1 nm), they are chem. stable and mech. robust, and have diminished solubility in most polar or nonpolar organic solvents. This solution-stable HOF exhibits an excellent electrochem. performance for Na+ ion storage. In particular, it enables an exceptional cycle life of >10 000 cycles at 1 A g-1, which is far superior to most other organic electrode materials. Theor. simulations indicate that the activation barrier for the intralayer or interlayer diffusion of Na+ ions within the organic frameworks is small.

Advanced Materials (Weinheim, Germany) published new progress about Battery cathodes. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Synthetic Route of 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Hao published the artcileNitrogen heterocyclic/phosphaphenanthrene derivative as a reactive additive for simultaneous improvement of flame retardancy, mechanical and dielectric properties of epoxy resins, Name: 3,5-Diamino-1,2,4-triazole, the main research area is nitrogen based reactive additive improve phys property epoxy resin.

Various approaches have been successfully applied to solve the flammability of epoxy resin (EP) materials, but enhanced flame retardance of EP is often along with deteriorated glass transition temperature (Tg) and mech. property. In order to prepare EP composites with good comprehensive performance, we synthesized a phosphorus-containing triazole derivative named TBO from 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide, 3,5-diamino-triazole and salicylaldehyde, and attached it into epoxy framework. With 0.75 wt% phosphorus loading, the 0.75-TBO/EP composite had a V-0 rating and a limiting oxygen index of 33%. 1.0-TBO/EP composite also had a V-0 rating and acquired a decrease of 37.6% in peak heat release rate. In addition, the tensile strength and flexural strength of 0.75-TBO/EP increased to 63.9 MPa and 146 MPa from 59 MPa and 134 MPa of EP resp. Meanwhile, the Tg values of TBO/EP elevated to some certain compared to EP. In a word, EP modified with TBO composites owned strong mech. property, higher Tg and excellent flame retardance, indicating great potential for application.

Polymer Degradation and Stability published new progress about Bending strength. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Name: 3,5-Diamino-1,2,4-triazole.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Hao published the artcileNitrogen heterocyclic/phosphaphenanthrene derivative as a reactive additive for simultaneous improvement of flame retardancy, mechanical and dielectric properties of epoxy resins, Category: isoquinoline, the main research area is nitrogen based reactive additive improve phys property epoxy resin.

Various approaches have been successfully applied to solve the flammability of epoxy resin (EP) materials, but enhanced flame retardance of EP is often along with deteriorated glass transition temperature (Tg) and mech. property. In order to prepare EP composites with good comprehensive performance, we synthesized a phosphorus-containing triazole derivative named TBO from 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide, 3,5-diamino-triazole and salicylaldehyde, and attached it into epoxy framework. With 0.75 wt% phosphorus loading, the 0.75-TBO/EP composite had a V-0 rating and a limiting oxygen index of 33%. 1.0-TBO/EP composite also had a V-0 rating and acquired a decrease of 37.6% in peak heat release rate. In addition, the tensile strength and flexural strength of 0.75-TBO/EP increased to 63.9 MPa and 146 MPa from 59 MPa and 134 MPa of EP resp. Meanwhile, the Tg values of TBO/EP elevated to some certain compared to EP. In a word, EP modified with TBO composites owned strong mech. property, higher Tg and excellent flame retardance, indicating great potential for application.

Polymer Degradation and Stability published new progress about Bending strength. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Guan, Hong-Hsiang published the artcilePlumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis, Name: 3,5-Diamino-1,2,4-triazole, the main research area is plumbagin anticancer agent dihydroorotase breast cancer; 4T1 cell; CAD; allantoinase; anticancer; crystal structure; dihydroorotase; dihydropyrimidinase; drug design; plumbagin; pyrimidine biosynthesis.

Dihydroorotase (DHOase) is the third enzyme in the de novo biosynthesis pathway for pyrimidine nucleotides, and an attractive target for potential anticancer chemotherapy. By screening plant extracts and performing GC-MS anal., we identified and characterized that the potent anticancer drug plumbagin (PLU), isolated from the carnivorous plant Nepenthes miranda, was a competitive inhibitor of DHOase. We also solved the complexed crystal structure of yeast DHOase with PLU (PDB entry 7CA1), to determine the binding interactions and investigate the binding modes. Mutational and structural analyses indicated the binding of PLU to DHOase through loop-in mode, and this dynamic loop may serve as a drug target. PLU exhibited cytotoxicity on the survival, migration, and proliferation of 4T1 cells and induced apoptosis. These results provide structural insights that may facilitate the development of new inhibitors targeting DHOase, for further clin. anticancer chemotherapies.

International Journal of Molecular Sciences published new progress about Antitumor agents. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Name: 3,5-Diamino-1,2,4-triazole.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Das, Rajesh published the artcileDesign of Bifunctional Zinc(II)-Organic Framework for Efficient Coupling of CO2 with Terminal/Internal Epoxides under Mild Conditions, Name: 3,5-Diamino-1,2,4-triazole, the main research area is zinc bisisophthalatenaphthalenediimide diaminotriazole MOF preparation gas adsorption surface area; cycloaddition catalyst zinc bisisophthalatenaphthalenediimide diaminotriazole MOF; optimized mol structure epoxide; crystal structure zinc bisisophthalatenaphthalenediimide diaminotriazole MOF.

The rational design of efficient catalytic materials for conversion of carbon dioxide (CO2), a greenhouse gas into valuable products has fascinated chemists ever since the advent of the area of green and sustainable catalysis. Herein, the authors report design of a bifunctional, 3D Zn-MOF, [Zn3(BINDI)(DATRZ)2(H2O)2]n by utilizing a Lewis acidic Zn(II) ion, long-chain, rigid aromatic tetracarboxylate ligand, N,N’-bis(5-isophthalic acid)naphthalenediimide (BINDIH4) and basic -NH2 rich 3,5-diamino-1,2,4-triazole (DATRZ) linker. The Zn-MOF possesses a BET surface area of 1085.8 m2/g and a high d. of CO2-philic -NH2 groups lined in the 1D channels promoting selective and recyclable CO2 adsorption with a high heat of interaction energy of 44.3 kJ/mol. The high surface area combined with the presence of Lewis acidic (LA) and basic sites rendered Zn-MOF an ideal bifunctional heterogeneous catalyst for efficient coupling of CO2 with terminal/internal epoxides under eco-friendly, solvent-free, RT and atm. pressure (balloon) conditions. Interestingly, Zn-MOF showed excellent catalytic activity for fixation of CO2 even from simulated flue gas/dilute CO2 gas. Remarkably, Zn-MOF showed high recyclability for up to 10 cycles with retaining the framework stability and catalytic activity. Overall, this work demonstrates the rational integration of Lewis acidic and basic sites in a 3D framework for the efficient utilization of CO2 under environment-friendly conditions.

Crystal Growth & Design published new progress about Crystal structure. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Name: 3,5-Diamino-1,2,4-triazole.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Das, Rajesh published the artcileDesign of Bifunctional Zinc(II)-Organic Framework for Efficient Coupling of CO2 with Terminal/Internal Epoxides under Mild Conditions, Related Products of isoquinoline, the main research area is zinc bisisophthalatenaphthalenediimide diaminotriazole MOF preparation gas adsorption surface area; cycloaddition catalyst zinc bisisophthalatenaphthalenediimide diaminotriazole MOF; optimized mol structure epoxide; crystal structure zinc bisisophthalatenaphthalenediimide diaminotriazole MOF.

The rational design of efficient catalytic materials for conversion of carbon dioxide (CO2), a greenhouse gas into valuable products has fascinated chemists ever since the advent of the area of green and sustainable catalysis. Herein, the authors report design of a bifunctional, 3D Zn-MOF, [Zn3(BINDI)(DATRZ)2(H2O)2]n by utilizing a Lewis acidic Zn(II) ion, long-chain, rigid aromatic tetracarboxylate ligand, N,N’-bis(5-isophthalic acid)naphthalenediimide (BINDIH4) and basic -NH2 rich 3,5-diamino-1,2,4-triazole (DATRZ) linker. The Zn-MOF possesses a BET surface area of 1085.8 m2/g and a high d. of CO2-philic -NH2 groups lined in the 1D channels promoting selective and recyclable CO2 adsorption with a high heat of interaction energy of 44.3 kJ/mol. The high surface area combined with the presence of Lewis acidic (LA) and basic sites rendered Zn-MOF an ideal bifunctional heterogeneous catalyst for efficient coupling of CO2 with terminal/internal epoxides under eco-friendly, solvent-free, RT and atm. pressure (balloon) conditions. Interestingly, Zn-MOF showed excellent catalytic activity for fixation of CO2 even from simulated flue gas/dilute CO2 gas. Remarkably, Zn-MOF showed high recyclability for up to 10 cycles with retaining the framework stability and catalytic activity. Overall, this work demonstrates the rational integration of Lewis acidic and basic sites in a 3D framework for the efficient utilization of CO2 under environment-friendly conditions.

Crystal Growth & Design published new progress about Crystal structure. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wu, Bo published the artcileNew Energetic Ionic Derivatives of Symmetric 4,6-Dihydrazinium-1,3,5-Triazine-2-One Cation with Low Impact and Friction Sensitivities, SDS of cas: 1455-77-2, the main research area is dihydrazino triazineone based energetic salt synthesis thermal stability friction.

A facile synthetic protocol was developed to synthesize unique energetic salts based on 4,6-dihydrazino-1,3,5-triazine-2-one in good to high yield from com. sources. The process was found to be practical and easily scalable. The resulting energetic compounds show good to excellent thermal stability with decomposition temperatures ranging from 180 °C to 331 °C. They possess low sensitivity to impact and friction (IS>20 J, FS>360 N), as well as pos. enthalpy of formation (148.9∼1381.7 kJ mol-1). Their detonation velocity (VD) values locate between 8301 m s-1 and 9282 m s-1, and detonation pressure (P) values range from 26.1 GPa to 37.2 GPa, in some cases, which are comparable to those of HMX. From the view of sensitivity and energy level, some of the energetic compounds prepared in this work exhibit potential as insensitive excellent performance energetic materials.

Propellants, Explosives, Pyrotechnics published new progress about Crystal structure. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, SDS of cas: 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem