Category: 27655-40-9

27655-40-9, Isoquinoline-5-sulfonic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 8L of thionyl chloride to the dry 20L glass reactor, add 2kg of 5-isoquinoline sulfonic acid, add 200ml of N,N-dimethylformamide (DMF) with stirring, and control the temperature of the reaction solution at 50 Below C, after the addition was completed, the temperature was raised to reflux and refluxed for 2 hours. Concentrated to dryness to give a white solid.Filtration gave a white solid which was re-slued twice and filtered to give a white-white 5-isoquinoline sulfonyl chloride hydrochloride solid.Into a 50 L glass reactor, 12 L of dichloromethane was added, and then 5-isoquinolinesulfonyl chloride hydrochloride was added to the front, and the temperature was lowered to -5 to 5 C, and a saturated aqueous solution of sodium hydrogencarbonate was added thereto with stirring to adjust the pH to 5 to. 6. Control the temperature of the reaction solution at -5 to 5 C, separate the dichloromethane phase, and extract the aqueous solution twice with dichloromethane (dichloromethane 4 L ¡Á 2), and combine the dichloromethane phase with anhydrous magnesium sulfate 0.5. ~ 1 kg of dry, filtered to give a pale yellow 5-isoquinoline sulfonyl chloride clear solution, to be used.

27655-40-9, As the paragraph descriping shows that 27655-40-9 is playing an increasingly important role.

Reference£º
Patent; Xuzhou Wan Bang Jinqiao Pharmaceutical Co., Ltd.; Jiangsu Wanbang Biochemical Pharmaceutical Group Co., Ltd.; Zhang Haifeng; Qiao Deshui; Gao Xueqin; (8 pag.)CN109970712; (2019); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

27655-40-9, Isoquinoline-5-sulfonic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a 5-Isoquinolinesulfonyl chloride A mixture of 5-isoquinolinesulfonic acid (4.18 g, 20 mmol), and phosphorus pentachloride (6.24 g, 30 mmol) in phosphorus oxychloride (20 mL) was heated at 120 C. for two days. The reaction mixture was cooled to ambient temperature and diluted with dry chloroform (60 mL). The white precipitate was collected, washed with dry chloroform and dried under high vacuum to give the title compound as a white solid (4.40 g, 83%) which was used for the next step without further purification. 1 H-NMR (300 MHz, CDCl3) delta 9.95 (s, 1H), 9.16 (d, J=6.8 Hz, 1H), 8.74 (d, J=6.8 Hz, 1H), 8.52 (t, J=7.0 Hz, 2H), 7.99 (t, J=7.3 Hz, 1H)., 27655-40-9

27655-40-9 Isoquinoline-5-sulfonic acid 241599, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; 3-Dimensional Pharmaceuticals, Inc.; US5891909; (1999); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem