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The solvent-free synthesis of 1-(hydroxyquinolyl)- and 1- (hydroxyisoquinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives is reported. The tested reaction conditions involved classical heating at 80-100 C and microwave agitation at the same temperature. Both reaction conditions yielded the compounds in good yield (57-92%), but the use of microwave conditions allowed the reaction time to be decreased. Georg Thieme Verlag Stuttgart New York.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

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Phthalide-3-carboxylic acids decarboxylate readily in the presence of imines, the product depending on the solvent used.In dimethyl sulfoxide, or in the absence of solvent, at 130 deg, the product is the 3-alkyl 3-hydroxyisoindolone or its dehydration product, but in acetic anhydride at 130 deg the product is a mixture of diastereoisomeric 3-acetylaminoalkylphthalides.The reactions can be applied to the synthesis of natural products such as the isoindoloisoquinoline and phthalideisiquinoline alkaloids.

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Isoquinoline – Wikipedia,
Isoquinoline | C9H2238N – PubChem

 

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Related Products of 3382-18-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3382-18-1, Name is 6,7-Dimethoxy-3,4-dihydroisoquinoline, molecular formula is C11H13NO2. In a Article,once mentioned of 3382-18-1

Reaction of 3,4-dihydro-beta-carboline (1) and 3,4-dihydroisoquinoline (7a-b) with ethoxymethyleneacetylacetone (2a) and ethyl ethoxymethyleneacetoacetate (2b) yielded new tetra- and tricyclic compounds (4a-b, 8a-d).The enaminone 4a on NaBH4 reduction led to the title compound.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H2346N – PubChem

 

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The intermolecular alpha-amidoalkylation reaction of adducts 3 obtained from acyl chlorides and 3,4-dihydroisoquinoline with an electron withdrawing group in the aromatic ring such as 7-nitro-3,4-dihydroisoquinoline towards aromatics has been investigated.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

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The (R)- and (S)-enantiomers of salsolidine, 2, were prepared in good yield and moderate enantioselectivity (33 and 27% e.e., respectively) by the addition of methyllithium to 6,7-dimethoxy-3,4-dihydroisoqiunoline 1 in the presence of the chiral oxazoline ligands 4 and 10.

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Isoquinoline – Wikipedia,
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The addition of the lithium carbanion of methyl phenyl sulfoxide and (R)-(+)-methyl p-tolyl sulfoxide to imines having at least one aryl substituent, under kinetically controlled conditions, gives beta-amino sulfoxides with good to modest diastereoselection.Under equilibrium controlled condition poor product diastereoselection results.The addition of these anions to 3,4-dihydro-6,7-dimethoxyisoquinoline is unique in that the most favorable product diastereoselection (92:8) is observed under equilibrium controlled conditions.Deuteration experiments suggest that equilibration occurs via a beta-amino alpha-lithio sulfinyl carbanion through a retro-Michael addition then Michael addition reaction sequence.This methodology allows for the construction of (R)-(+)-tetrahydropalmatine in four efficient synthetic steps.

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Reference:
Isoquinoline – Wikipedia,
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To the method, 6,7 -methoxy – 3333184-dihydroisoquinoline 99.0% hydrochloride. is subjected to further reaction 3,4 – reaction to obtain the target product, and then the reaction liquid is cooled and dried to obtain the target product. through the method, and then the reaction liquid is cooled and dried after being subjected to a one-pot reaction for, % or more, yield, or ?0.15%), more. technical safety grades are obviously reduced, wastes are obtained . The process operation is extremely simple,pot method reaction after reaction is carried out through a pot method to obtain the target product, (and the, technological operation is extremely. simple, and the, equipment cost is obviously reduced by a pot method after the reaction solution, is subjected 75% to a one-pot. method reaction to obtain a target product containing the oxaloyl chloride solution cGMP through a one-pot reaction process after the reaction solution is filtered 6,7 – by a one-pot method. (by machine translation)

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Isoquinoline – Wikipedia,
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The enantiomers of 1,2,3,4-tetrahydroisoquinoline- and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-acetic acids were prepared via Burkholderia cepacia lipase (lipase PS-D)-catalyzed kinetic resolution of the corresponding ethyl and 2-methoxyethyl esters using enantioselective (E > 200) hydrolysis in DIPE. The (S)-acids were produced enzymatically, whereas the (R)-acids were obtained via the chemical hydrolysis of the unreacted (R)-esters. The solvent and its water content had major effects on both reactivity and enantioselectivity. The methoxyethyl moiety of the ester had a key role concerning the reactivity of the substrates.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

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Biologically active 1-subsutituted tetrahydroisoquinoline alkaloids, (-)-trolline, (-)-crispine A, and (-)-crispine E were synthesized using a chiral isoquinolinecarbaldehyde as a key material. The aldehyde was readily obtained from a 1-cyanoisoquinoline, and subjected to a Horner-Wadsworth-Emmons reaction. The chiral tetrahydroisoquinoline derivative thus obtained was used for the synthesis of the optically active isoquinoline alkaloids.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

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In order to explore the influence of sulfate groups on the bioactivity profiles of marine alkaloids of the lamellarin class, three such alkaloids, lamellarin alpha lamellarin alpha 13,20-disulfate and H, were synthesized and their activities against HIV-1 integrase and cancer cell ines were compared with those of lamellarin alpha 20-sulfate, which is a selective inhibitor of HIV-1 integrase. Lamellarin alpha does not inhibit HIV-1 integrase but shows moderate cytotoxicity with good cell line selectivity. Lamellarin alpha13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. Lamellarin H is a more potent inhibitor of HIV-1 integrase but lacked the specificity required to be medicinally useful. Copyright

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H2398N – PubChem