Category: 58142-99-7

58142-99-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58142-99-7,5-Iodoisoquinoline,as a common compound, the synthetic route is as follows.

Dissolve (trans)-4-methylhexahydropyrrole[3,4-b][1,4]oxazine (333 mg, 2.3 mmol) in toluene (20 mL)Add triethylamine (2 mL), 5-iodoisoquinoline (718 mg, 2.8 mmol), XPhos (110 mg, 0.23 mmol), cesium carbonate (2.25 g, 6.9 mmol) and palladium acetate (52 mg) successively. , 0.23 mmol), heated to 90C under nitrogen atmosphere overnight. The mixture was filtered off with suction and the filtrate was concentrated and purified by column chromatography to give the title compound (600 mg).

The synthetic route of 58142-99-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Wu Yongyong; Yu Hua; Wang Kunjian; Li Xiaoyong; Sun Ling; Wang Runjiang; Chen Qiangqiang; Yang Long; Song Hongmei; Zeng Hong; Zhang Hong; Ye Qijun; Wang Lichun; Wang Jingyi; (98 pag.)CN107540659; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

58142-99-7,58142-99-7, 5-Iodoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tert-butyl (R)-2-methyl-5-carbonylpiperazine-1-carboxylate (1.1 g, 5.14 mmol),5-Iodoisoquinoline(1.64 g, 6.43 mmol), cuprous iodide (356 mg, 1.87 mmol), potassium phosphate (3.34 g, 9.87 mmol), ethylenediamine (3 mL), 4A molecular sieves (10 g) dissolved in 1,4- Dioxane (50 mL) reacts overnight at 120C in a nitrogen atmosphere.The reaction was monitored by LCMS, followed by filtration with water. The filtrate was extracted with dichloromethane three times. The organic phases were combined, dried, and the solvent was removed by rotary evaporation. Column chromatography gave 4-isoquinoline-(R)-2-methyl-5-carbonyl. Tert-butyl piperazine-1-carboxylate (537 mg, yield: 31%).

58142-99-7 5-Iodoisoquinoline 11391181, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Wu Yongyong; Yu Hua; Wang Kunjian; Li Xiaoyong; Sun Ling; Wang Runjiang; Chen Qiangqiang; Yang Long; Song Hongmei; Zeng Hong; Zhang Hong; Ye Qijun; Wang Lichun; Wang Jingyi; (98 pag.)CN107540659; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem