93117-08-9,93117-08-9, 5-Aminoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The bismethyl triazene compound (7) was synthesized as described in Scheme 2: 5-amino-isoquinolinone (50 mg, 1 eq, 0.312 mmol) was dissolved in 50 % / 50 % solution of water/hydrochloric acid (2.5 mL / 2.5 mL) in the dark. The mixture was cooled to -5 C. A solution of sodium nitrite (43.1 mg, 2 eq, 0.624 mmol) in water (1 mL) was added dropwise. After 15 min at -5 C, dimethylamine (40% v / v) (0.237 mL, 6 eq, 1.87 mmol) was added slowly dropwise directly. After 30 min at -5 C, the mixture was added dropwise to a saturated solution of sodium bicarbonate and left to precipitate for an hour. Filtration of the mixture yielded a light-brown solid (54 mg, 80%). 1H NMR (300 MHz, DMSO-d6) delta ppm 11.24 (s, 1H, NH), 7.95 (d, 1H, J = 7.5 Hz, ArH), 7.58 (dd, 1H, J = 7.8 Hz, 1.2 Hz, ArH), 7.36 (t, 1H, J = 8.1 Hz, ArH), 7.13 (d, 1H, J = 7.2 Hz, ArH), 7.04 (d, 1H, J = 6.9 Hz, ArH), 3.53 (s, 3H, NCH3), 3.22 (s, 3H, NCH3). 13C NMR (400 MHz, DMSO-d6): delta ppm 162.16, 145.44, 133.13, 128.50, 127.61, 126.79, 123.66, 118.60, 100.76, 43.37 and 36.50. ESI m/z 217 (MH+).
The synthetic route of 93117-08-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Goodfellow, Elliot; Senhaji Mouhri, Zhor; Williams, Christopher; Jean-Claude, Bertrand J.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 3; (2017); p. 688 – 694;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem