Category: isoquinoline

23687-26-5, 6-Aminoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 41 – Synthesis of Compound 62; 1. 200 mg (1.35 mmol) of 6-aminoisoquinoline were disolved in 20 ml ofacetonitrile. 239,568 mg (1 ,35 mmol) of N-bromsuccinimide was added. The reaction mixture was stirred for 4 h at room temperature. The reaction mixture was evaporated and dichloromethane was added. The organic phase was washed with water and dried. 224 mg of 5-brromo-isoquinolin-6-ylamine were obtained; HPLC/MS (B) 1.00 min, [M+H] 224.

23687-26-5, The synthetic route of 23687-26-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK PATENT GMBH; DORSCH, Dieter; JONCZYK, Alfred; HOELZEMANN, Guenter; AMENDT, Christiane; ZENKE, Frank; WO2012/595; (2012); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215453-51-3,7-Bromo-1-chloroisoquinoline,as a common compound, the synthetic route is as follows.

215453-51-3, 7-Bromo-1-chloroisoquinoline (1-1) (79 mg, 0.327 mmol, 1.0 equiv) and Ethyl carbazate (34 mg, 0.33 mmol, 1.0 equiv) were suspended in EtOH (1.5 mL). The reaction mixture was irradiated in microwave at 170 C. for 40 minutes. The crude mixture was purified with reverse phase HPLC (H2O/CH3CN gradient w/0.1% TFA present) to yield 9-bromo[1,2,4]triazolo[3,4-a]isoquinolin-3(2H)-one (1-2). LRMS m/z (M+H) 263.9 and 264.9 found, 264.1 and 265.1 required.

The synthetic route of 215453-51-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Arrington, Kenneth L.; Brnardic, Edward J.; Dudkin, Vadim Y.; Fraley, Mark E.; Huang, Shaei Y.; Wang, Cheng; US2007/254879; (2007); A1;,
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6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The compounds 1-9 were synthesized using themixed anhydrides method of peptide synthesis (18).The suitable acid (10 mM) was dissolved in DMF(15 mL) and THF (15 mL) was added. Next N-methylmorpholine (10 mM, 1.1 mL) was added andthe mixture was stirred under nitrogen and chilled to-15 O C. Isobutyl chloroformate (10 mM, 1.3 mL) wasadded dropwise to keep the temperature below -15 O C. Then, the suitable amine: 2- or 4-fluorobenzy-lamine (2-F-BZA, 4-F-BZA); 2- or 4-methoxyben-zylamine (2-OMe-BZA, 4-OMe-BZA); 3- or 4-methylbenzylamine (3-Me-BZA, 4-Me-BZA) or 1-naphthylmethylamine (10 mM) in THF was added insmall portions and the reaction mixture was stirred at -15 O C for 30 min and at room temperature for 1 h.The solution was concentrated in vacuo and theresidue was dissolved in CHCl 3 (40 mL). This solu-tion was washed with 20 mL portions of 1M HCl,saturated NaHCO 3 solution and saturated NaCl solu-tion, then dried with anhydrous MgSO 4 , filtered andconcentrated in vacuo. The obtained compoundswere purified by crystallization with EtOAc/hexaneor MeOH/Et 2 O. All stages of the synthesis were con-trolled by TLC. The purity and identity of the finalcompounds were determined by HPLC, elementalanalyses, 1 H NMR, MS. The elemental analyses werewithin ¡À 0.4percent of the theoretical value. The analyticaldata confirmed that the purity of the products was ?95percent. The general procedure for the synthesis of theobtained compounds is shown in Schemes 1 and 2., 6624-49-3

As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.

Reference£º
Article; Strupi?ska, Marzanna; Rostafi?ska-Suchar, Grazyna; Jakubowicz, Bart?omiej; Klimkiewicz, Paulina; Lal, Ewelina; Oczkowski, Mateusz; Prochniak, Ewa; Pirianowicz-Chaber, Elzbieta; Mazurek, Aleksander P.; Acta poloniae pharmaceutica; vol. 74; 4; (2017); p. 1111 – 1118;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.

Intermediate compound 3a (315 mg, 0.600 mmol) was dissolved in anhydrous DCM. 5-isoquinoline sulfonyl chloride ¡¤ HCl (190.3 mg, 0.721 mmol) and TEA (100 ml, 0.721 mmol) were added to the mixture, and the mixture was stirred at room temperature for 2 hours.After confirming the completion of the reaction,After acidification with saturated ammonium chloride solution and extraction with DCM,Dried over anhydrous MgSO4,Filtered and rotary evaporated.Purification of the compound was purified by column chromatography (methanol: chloroform = 1: 45) to obtain white crystals; Yield: 54.0%, 105627-79-0

105627-79-0 Isoquinoline-5-sulfonyl chloride hydrochloride 13116932, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Gwangju Institute of Science and Technology; Kim, Yong Chul; Lee, Ka Eun; (33 pag.)KR101732732; (2017); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131002-09-0,6-Chloroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

6-chloroisoquinolin-1 (2Eta)-one (12 mmol), bis(2-fluorophenyl)disulfide (10 mmol), hexafluoroantimonic acid were sequentially added to a pressure-resistant reaction tube at room temperature. Silver (10 mmol) and dichloroethane (6 mL). The reaction mixture was then reacted at 90 C for 10 hours. The reaction was stopped, concentrated under reduced pressure to give a crude material, which was washed with a mixture of petroleum ether and ethyl acetate. 4-(2-Fluorophenylthio)-6-chloroisoquinolin-1 (2H)-one. Yield 70%;, 131002-09-0

As the paragraph descriping shows that 131002-09-0 is playing an increasingly important role.

Reference£º
Patent; Nankai University; Zhu Youquan; He Jingli; Niu Yunxia; Han Tingfeng; Li Haoyu; (14 pag.)CN108822035; (2018); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84468-15-5,Isoquinoline-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

The powdered aryl or heteroaryl sulphonyl chloride (ARYL-SOACI) (1 mmol) was added in small portions to a cooled flask (0 C) containing the ethylene diamine (10 mmol) in dry dichloromethane (20 ml) with vigorous stirring. The reaction was then stirred for 3 hours at room temperature under a nitrogen atmosphere. After checking its conclusion by TLC, the reaction mixture was extracted with 10% aqueous hydrochloric acid solution. After separation of the two resulting phases, the pH of the aqueous layer was adjusted to 10 with a 10% aqueous sodium hydroxide solution and the aqueous layer was extracted with dichloromethane. The organic layer was then dried (anhydrous magnesium sulphate), filtered and evaporated under reduced pressure to give the aryl-sulphonamido-alkylamine as a solid. The aryl or heteroaryl sulphonyl chlorides used in the procedure described above were either obtained from commercial sources or were prepared through reaction of the respective sulphonic acids (2.3 mmol) with thionyl chloride (2.2 ml) in the presence of dimethylformamide (0.3 ml). The reaction was carried out under reflux for 2 hours and, after cooling to room temperature, the reaction mixture was evaporated under reduced pressure to give a solid sulphonyl chloride which was used immediately in the next step., 84468-15-5

The synthetic route of 84468-15-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTEX TECHNOLOGY LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; WO2005/11697; (2005); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147497-32-3,6-Bromo-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

The compound (2.253 g) obtained in Example 17-1 was dissolved in anhydrous THF (11 ml) and added with a 1 mol/l borane-THF complex/THF solution (manufactured by Kanto Chemical Co., Inc.) (55.4ml). The whole was refluxed overnight under heating. After the whole was left for cooling, methanol was added thereto and the solvent was distilled off. The resultant was added with 1 mol/l hydrochloric acid and refluxed under heating for 3 hours. After completion of the reaction, the solution was cooled with ice and added with a 1 mol/l sodium hydroxide aqueous solution and 27% ammonium water, followed by extraction with chloroform. The extract was dried with magnesium sulfate and the solvent was distilled off. The resultant was dissolved in anhydrous dichloromethane (40 ml), added with triethylamine (1.53 ml), and cooled with ice. Trifluoroacetic anhydride (1.55 ml) was added thereto and the whole was stirred at room temperature for 1 hour. After completion of the reaction, the resultant was added with a saturated aqueous sodium hydrogen carbonate solution, subjected to extraction with chloroform, and dried with magnesium sulfate. The solvent was distilled off under reduced pressure, thereby obtaining the subject compound (2.23 g) as a white solid. MS(FAB,Pos.):m/z=308,310[M+H]+, 147497-32-3

147497-32-3 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one 21865450, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Kureha Corporation; EP1724263; (2006); A1;,
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552331-06-3,552331-06-3, 6-Bromo-3-chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Chloro-6-(pyrimidin-5-yl)isoquinoline Method E A suspension of 6-bromo-3-chloroisoquinoline (62 mg, 0.27 mmol), pyrimidin-5- ylboronic acid (45 mg, 0.36 mmol), Pd(PPh3)4 (29.5 mg, 0.026 mmol) and CsF (1 17 mg, 0.77 mmol) in DME/MeOH (3/1 mL) was stirred at 150 X1 under microwave irradiation for 30 minutes. The reaction mixture was filtered and concentrated in vacuo. The residue was purified using Biotage silica gel column chromatography eluting with between 20- 60% EtOAc in cyclohexane to afford the title compound (26 mg, 42%). 1 H NMR (500 MHz, CDCI3): delta 9.32 (s, 1 H), 9.17 (s, 1 H), 9.09 (s, 2H), 8.16 (dt, J = 8.5, 0.9 Hz, 1 H), 7.98 (dd, J = 1 .8, 0.9 Hz, 1 H), 7.88 – 7.78 (m, 2H). LCMS (ESI) Rt = 2.14 minutes MS m/z 242 [M+H]+

As the paragraph descriping shows that 552331-06-3 is playing an increasingly important role.

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; HOELDER, Swen; BLAGG, Julian; CHEUNG, Jack; ATRASH, Butrus; SHELDRAKE, Peter; WO2014/37751; (2014); A1;,
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13130-79-5, 1-Bromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-biphenylacetic acid (1. [0G,] 4.7 [MMOL)] in 10 mi of anhydrous DMF was added HBTU (2.1g, 5.7 [MMOL)] and 1.0 ml of DIEA. The mixture was stirred at room temperature for 10 min, and then 1-bromo-3-isoquinolinamine (0.68g, 4.7 [MMOL)] was added. After stirring over night, the mixture was poured into water, acidified with 10% citric acid, and extracted with ethyl acetate. The organic extracts were washed with water and brine, dried over [NA2SO4.] After the condensation of the solvent, the residue was purified by flash column chromatography [(SIO2,] 1: [1] hexane: ethyl aceate) to provide the title compound (1.7g, 86%) as a light yellow solid. ‘H-NMR (400 MHz, [CDC . S)] : 3.83 (s, 3H), 7.33-7. 37 (m, 1H), 7.42-7. 48 (m, 4H), 7.52- 7.58 (m, 1 H), 7.60-7. 64 (m, 4H), 7.65-7. 70 (m, 1 H), 7.80 (d, 1 H,), 7. [61] (s, 1H), 8.18 (d, 1 H), 8.56 (s, 1H) ; LC/MS (m/z) : 418 (M+1) [+.]

13130-79-5, 13130-79-5 1-Bromoisoquinolin-3-amine 289845, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; TRANSTECH PHARMA, INC.; WO2004/14844; (2004); A2;,
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22246-12-4, 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate A6 2-(4-isobutylphenyl)-6-methoxy-3.4-dihvdroisoquinolin-l(2H)-one vial, 6-methoxy-3,4-dihydroisoquinolin-l(2H)-one (0.25 g, 1.411 mmol) was dissolved in N-dimethylformamide (2.82 ml). To this was added l-bromo-4-isobutylbenzene (0.451 g, 2.116 mmol) and potassium carbonate (0.390 g, 2.82 mmol). The reaction mixture was flushed with nitrogen, charged with copper(I) iodide (0.161 g, 0.847 mmol) and heated to 150 C for 24 h. The reaction mixture was cooled to room temperature, quenched with water and extracted three times with dichloromethane. The organic layers were combined, passed through a phase separator and concentrated. The crude material was purified via silica gel chromatography using 0-75% ethyl acetate in heptanes to afford the desired product (190 mg, 0.614 mmol, 43.5 % yield) as a light orange solid. NMR (400 MHz, Chloroform-d) delta 8.12 (d, J = 8.7 Hz, 1H), 7.32 – 7.27 (m, 2H), 7.24 – 7.15 (m, 2H), 6.89 (dd, J = 8.7, 2.6 Hz, 1H), 6.77 – 6.65 (m, 1H), 3.96 (dd, J = 7.0, 6.0 Hz, 2H), 3.86 (s, 3H), 3.09 (t, J = 6.4 Hz, 2H), 2.50 (d, J = 7.1 Hz, 2H), 1.90 (dh, J = 13.5, 6.8 Hz, 1H), 0.94 (d, J = 6.6 Hz, 6H). LC MS (m/z, MH+): 310.4., 22246-12-4

The synthetic route of 22246-12-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; BURKS, Heather Elizabeth; KARKI, Rajeshri Ganesh; KIRBY, Christina Ann; NUNEZ, Jill; PEUKERT, Stefan; SPRINGER, Clayton; SUN, Yingchuan; THOMSEN, Noel Marie-france; WO2015/92634; (2015); A1;,
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