Category: isoquinoline

63927-23-1, 5-Bromo-8-nitroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63927-23-1, Iodomethane (506 mmol) was added to a solution of 5-bromo-8-nitroisoquinoline (101 mmol) in N,N-dimethylformamide (200 mL) and the reaction mixture was maintained for 16 h at 40 C. The precipitated solids were collected by filtration, washed with ether (2¡Á250 mL), and dried to provide 5-bromo-8-nitro-N-methylisoquinolinium iodide in 83% yield as a red solid.

As the paragraph descriping shows that 63927-23-1 is playing an increasingly important role.

Reference£º
Patent; Memory Pharmaceuticals Corporation; US2010/29629; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The ligand (1 eq) and sodium methoxide (1.1 eq) were dissolved in dry methanol (10mL) and after stirring at room temperature for 15min, [RhCp*(mu-Cl)Cl]2 (0.9 eq) was added. The mixture was stirred under argon atmosphere and at room temperature for 24h. The solvent was subsequently removed under reduced pressure; the obtained residue was taken up in CH2Cl2 and filtered to remove insoluble reaction by-products. The filtrate was concentrated to a volume of 2mL under reduced pressure. Precipitation with n-hexane afforded the desired product in moderate to good yields (53?64percent)., 6624-49-3

The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Doemoetoer, Orsolya; Hackl, Carmen M.; Bali, Krisztina; Roller, Alexander; Hejl, Michaela; Jakupec, Michael A.; Keppler, Bernhard K.; Kandioller, Wolfgang; Enyedy, Eva A.; Journal of Organometallic Chemistry; vol. 846; (2017); p. 287 – 295;,
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Isoquinoline | C9H7N – PubChem

51206-40-7, 1,4-Dibromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,51206-40-7

A mixture of 1.00 g, 3.49 mMol of 1,4-dibromoisoquinoline (Intermediate A) from step 1 and 4-chloroaniline were melted together at 140. The reaction mixture turned into a deep red liquid and after about 10 minutes the reaction mixture solidified and was done. The reaction mixture was broken up and triturated with a 50/50 methanol/THF mixture then filtered and air dried without further purification. wt. 0.75 g, 64.4%, mp.=260-263. Rf=0.58 in 40% ethyl acetate in hexanes.

51206-40-7 1,4-Dibromoisoquinoline 640981, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US6689883; (2004); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

21560-29-2, 1-Chloro-6,7-dimethoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 1-chloro-6,7-dimethoxyisoquinoline(50 mg, 0.22 mmol) and 4-fluorophenol (25.06 mg, 0.22 mmol) in DMA (3 mL) wasstirred under a nitrogen atmosphere for 5 minutes. Sodium hydride (22.35 mg,0.56 mmol; 60% in mineral oil) was added to the reaction mixture and stirred atambient temperature for 15 minutes. Next the mixture was stirred and heated at 200C for 3 minutes undermicrowave irradiation. The reaction mixture was quenched with methanol (0.5 mL)and the crude material was purified by flash column chromatography eluting witha gradient of ethyl acetate and methanol (1:0 to 1:1) to give a gum. Theproduct was purified by reverse phase chromatography and the desired product (33.0mg, 49.3%) was obtained as a solid. HPLCpurity: >99% (215 nM), >99% (254 nM), >99% (280 nM). 1H NMR(400 MHz, DMSO-d6) dppm 3.94 (s, 3 H), 3.92 (s, 3 H), 7.23 – 7.31 (m, 4 H), 7.36- 7.43 (m, 2 H), 7.58 (s, 1 H), 7.76 (d, J=5.5 Hz, 1 H). HRMS m/z calcd for C17H14FNO3[M+H]+ 300.1031, found 300.1030., 21560-29-2

The synthetic route of 21560-29-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hu, Yun-Jin; St.-Onge, Miguel; Laliberte, Sebastien; Vallee, Frederic; Jin, Shujuan; Bedard, Leanne; Labrecque, Jean; Albert, Jeffrey S.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 14; (2014); p. 3199 – 3203;,
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Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59139-93-4,2-(1-Oxoisoquinolin-2(1H)-yl)acetic acid,as a common compound, the synthetic route is as follows.,59139-93-4

General procedure: A suspension of carboxylic acid 6a (168mg, 0.77mmol) in dry CH2Cl2 was cooled to-5C and HOBt was added (250mg, 1.85mmol). After 20min, the reaction mixture was further cooled to-15C and treated with EDC¡¤HCl (355mg, 1.85mmol). Finally, a cold solution of pinandiol l-leucine boronate trifluoroacetate salt 7 in dry CH2Cl2 (292mg, 0.77mmol) and DIPEA (160muL, 0.92mmol) were added in sequence and the reaction mixture was stirred at-15C for 1h and then at room temperature for 2h. Then, the organic layer was washed with 0.1M KHSO4, 5% NaHCO3, and brine, dried over Na2SO4, filtered, and finally evaporated to give a crude that was triturated in Et2O and filtered, to afford the amide by-product ( 9a) as a solid. The ether solution was evaporated to give crude 8a which was used in the next reaction without further purification (293mg, 82%)

The synthetic route of 59139-93-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Troiano, Valeria; Scarbaci, Kety; Ettari, Roberta; Micale, Nicola; Cerchia, Carmen; Pinto, Andrea; Schirmeister, Tanja; Novellino, Ettore; Grasso, Silvana; Lavecchia, Antonio; Zappala, Maria; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 1 – 14;,
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Isoquinoline | C9H7N – PubChem

891785-28-7, 6-Bromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

891785-28-7, [00344] 6-Bromo-3-fluoroisoquinoline: To a mixture of 6-bromoisoquinolin-3- amine (0.71 g, 3.18 mmol) in pyridine hydrofluoride (10 mL, 3.18 mmol) at -780C was carefully added sodium nitrite (0.26 g, 3.82 mmol). The reaction mixture was stirred at – 780C for 5 minutes. The reaction mixture was then warmed to room temperature over 40 minutes. The mixture was poured into an ice bath and the pH was adjusted to >9 with Na2CO3. The mixture was filtered to recover a yellow-purple solid. The solid was dissolved in EtOAc and water with stirring. The mixture was extracted with EtOAc (3 x 200 mL). The EtOAc was washed with brine, dried over Na2SO^ filtered and concentrated. The residue was taken up in DCM-MeOH and adsorbed onto silica gel. Purification by chromatography on silica gel eluting with EtOAc 0-7 % in hexanes provided the product (500 mg, 70 %). LCMS (API-ES) m/z: 226, 228 (M+H+).

The synthetic route of 891785-28-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2009/11880; (2009); A2;,
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Isoquinoline | C9H7N – PubChem

552331-06-3,552331-06-3, 6-Bromo-3-chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 6-bromo-3-chloroisoquinoline (Frontier Scientific, 1.594 g, 6.57 mmol) and 2,2-dimethylpropane-1 ,3-diol (684 mg, 6.57 mmol) in cyclopentyl methyl ether (20 mL) was added cesium carbonate (2.354 g, 7.23 mmol) at 23C. The reaction mixture was heated to 120C for 18 h. The reaction mixture was cooled to RT, diluted with ethyl acetate (50 mL) and washed with water (30 mL), brine (30 mL) and the resulting organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel chromatography (80 g Isco Rf Gold Column, 0-100% ethyl acetate//so- hexanes gradient) to afford the title compound (461 mg, 23%) as a white solid

As the paragraph descriping shows that 552331-06-3 is playing an increasingly important role.

Reference£º
Patent; GILEAD SCIENCES, INC.; SELCIA LIMITED; ACIRO, Caroline; STEADMAN, Victoria Alexandra; PETTIT, Simon Neil; POULLENNEC, Karine G.; LAZARIDES, Linos; DEAN, David Kenneth; DUNBAR, Neil Andrew; HIGHTON, Adrian John; KEATS, Andrew John; SIEGEL, Dustin Scott; KARKI, Kapil Kumar; SCHRIER, Adam James; JANSA, Petr; MACKMAN, Richard; WO2013/185103; (2013); A1;,
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Isoquinoline | C9H7N – PubChem

27655-40-9, Isoquinoline-5-sulfonic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a 5-Isoquinolinesulfonyl chloride A mixture of 5-isoquinolinesulfonic acid (4.18 g, 20 mmol), and phosphorus pentachloride (6.24 g, 30 mmol) in phosphorus oxychloride (20 mL) was heated at 120 C. for two days. The reaction mixture was cooled to ambient temperature and diluted with dry chloroform (60 mL). The white precipitate was collected, washed with dry chloroform and dried under high vacuum to give the title compound as a white solid (4.40 g, 83%) which was used for the next step without further purification. 1 H-NMR (300 MHz, CDCl3) delta 9.95 (s, 1H), 9.16 (d, J=6.8 Hz, 1H), 8.74 (d, J=6.8 Hz, 1H), 8.52 (t, J=7.0 Hz, 2H), 7.99 (t, J=7.3 Hz, 1H)., 27655-40-9

27655-40-9 Isoquinoline-5-sulfonic acid 241599, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; 3-Dimensional Pharmaceuticals, Inc.; US5891909; (1999); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

660830-62-6, Ethyl 7-bromoisoquinoline-3-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,660830-62-6

Production Example 46-3 Ethyl 7-[4-[(4-fluorobenzyl)oxy]-2-oxopyridin-1(2H)-yl]isoquinoline-3-carboxylate At room temperature, 4-(fluorobenzyl)oxy-2(1H)-pyridone (337 mg), potassium carbonate (639 mg) and copper(I) iodide (322 mg) were successively added to a DMF solution (15 mL) of the compound (431 mg) obtained in Production Example 46-2. The reaction liquid was stirred at 100 C. for 12 hours, then poured into diluted ammonia water. The formed precipitate was collected by filtration, the solid was washed with water, then dissolved in chloroform. The organic layer was washed with saturated saline water, then dried with anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, then the residue was dissolved in ethanol (60 mL), and concentrated sulfuric acid (3 mL) was added and stirred with heating under reflux for 12 hours. The reaction liquid was poured into aqueous saturated sodium hydrogencarbonate solution, and extracted with ethyl acetate. The organic layer was washed with saturated saline water, then dried with anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (methanol:chloroform=1:200) to obtain the entitled compound (109 mg).

As the paragraph descriping shows that 660830-62-6 is playing an increasingly important role.

Reference£º
Patent; Sakuraba, Shunji; Kameda, Minoru; Kishino, Hiroyuki; Haga, Yuji; Otake, Norikazu; Moriya, Minoru; US2009/264426; (2009); A1;,
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Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.164148-92-9,tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.

Step 2: Synthesis of tert-butyl 6-((1-(2-(tert-butyl)pyrimidin-4-yl)-2-isopropyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate To a stirred solution of 1-(2-(tert-butyl)pyrimidin-4-yl)-2-isopropyl-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one (176 mg, 0.49 mmol, 1.0 eq.) in 3 mL of toluene was added m-CPBA (169 mg, 0.98 mmol, 2 eq.) and allowed to stir at rt for 1 h. Further, tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (146 mg, 0.58 mmol, 1.2 eq.) and DIPEA (0.33 mL, 1.96 mmol, 4 eq.) were added and allowed to stir at rt for overnight. After completion of reaction, solvent was removed under reduced pressure; residue was diluted with water and extracted with ethyl acetate (50 mL*3). The combined organic layer was washed with brine solution (10 mL), dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford crude product which was purified by flash chromatography to afford tert-butyl 6-((1-(2-(tert-butyl)pyrimidin-4-yl)-2-isopropyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate (120 mg, 43.74%) as yellow solid.

164148-92-9, 164148-92-9 tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate 2756371, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; Gupta, Ashu; KUMAR, Varun; (498 pag.)US2019/106427; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem