Tag: 327.8296

Li, Hang et al. published their research in Pharmazie in 2014 | CAS: 105628-07-7

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Synthetic Route of C14H18ClN3O2S

Design, synthesis and evaluation of biological activity of novel fasudil analogues was written by Li, Hang;Wang, Donghua;Liu, Shuai;Sun, Changhai;Chen, Meizhu;Wang, Xinran;Chen, Ligong. And the article was included in Pharmazie in 2014.Synthetic Route of C14H18ClN3O2S This article mentions the following:

Nine isoquinoline Rho kinase inhibitors were designed and synthesized on the basis of a ligand-binding pocket model. With fasudil, the only Rho kinase inhibitor marketed to date, as a reference compound, their biol. activities were determined, including assays of Rho kinase inhibitory activity, synapse formation, cell viability. Bio-assays were performed by means of MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assays and lactate dehydrogenase (LDH) assays. The obtained results indicated that (R)-6H-1-(5-isoquinolinesulfonyl)-2-hydroxy methyl-1-pyrrolidine and (R)-6H-1-(5-isoquinolinesulfonyl)-2-chloromethyl-1-pyrrolidine exhibited excellent Rho kinase inhibitory activity, deactivation of Rho kinase led to accelerated synapse formation and enhanced cell viability. Therefore they might be potential candidates for preventing various neurol. disorders. The brief study on the structure-activity relationship of these isoquinoline analogs demonstrated that modification of inhibitors targeting region D of the Rho kinase binding pocket is quite efficacious, the existence of free amino, chloro- or hydroxyl group as binding sites with region D of Rho kinase is necessary for increasing the inhibitory activity. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7Synthetic Route of C14H18ClN3O2S).

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Synthetic Route of C14H18ClN3O2S

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Li, Hang et al. published their research in Pharmazie in 2014 | CAS: 105628-07-7

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Synthetic Route of C14H18ClN3O2S

Design, synthesis and evaluation of biological activity of novel fasudil analogues was written by Li, Hang;Wang, Donghua;Liu, Shuai;Sun, Changhai;Chen, Meizhu;Wang, Xinran;Chen, Ligong. And the article was included in Pharmazie in 2014.Synthetic Route of C14H18ClN3O2S This article mentions the following:

Nine isoquinoline Rho kinase inhibitors were designed and synthesized on the basis of a ligand-binding pocket model. With fasudil, the only Rho kinase inhibitor marketed to date, as a reference compound, their biol. activities were determined, including assays of Rho kinase inhibitory activity, synapse formation, cell viability. Bio-assays were performed by means of MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assays and lactate dehydrogenase (LDH) assays. The obtained results indicated that (R)-6H-1-(5-isoquinolinesulfonyl)-2-hydroxy methyl-1-pyrrolidine and (R)-6H-1-(5-isoquinolinesulfonyl)-2-chloromethyl-1-pyrrolidine exhibited excellent Rho kinase inhibitory activity, deactivation of Rho kinase led to accelerated synapse formation and enhanced cell viability. Therefore they might be potential candidates for preventing various neurol. disorders. The brief study on the structure-activity relationship of these isoquinoline analogs demonstrated that modification of inhibitors targeting region D of the Rho kinase binding pocket is quite efficacious, the existence of free amino, chloro- or hydroxyl group as binding sites with region D of Rho kinase is necessary for increasing the inhibitory activity. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7Synthetic Route of C14H18ClN3O2S).

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Synthetic Route of C14H18ClN3O2S

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Zhu, Maoying et al. published their research in Pakistan Journal of Zoology in 2017 | CAS: 105628-07-7

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Product Details of 105628-07-7

Effect of fasudil hydrochloride and H2 on the post-thaw viability of cryopreserved porcine adipose-derived stem cells was written by Zhu, Maoying;Ji, Yuntao;Wang, Xiaoyu;Pu, Junying;Qu, Changqing. And the article was included in Pakistan Journal of Zoology in 2017.Product Details of 105628-07-7 This article mentions the following:

The present study is to explore the effect of fasudil hydrochloride and H2 on the post-thaw viability of cryopreserved porcine adipose-derived stem cells. Four different combinations of cryoprotectants with and without hydrogen gas (H) purified H2 was dissolved into normal cryopreservation solution for 2 h under 0.6 MPa were tested including the following groups: control (CK), 100μm GSH, 10μm fasudil hydrochloride (FH) and a combination of the two (GSH + FH). A solution of 10% (volume/volume) Me2SO + 20% FBS was used as the standard cryopreservation solution After 2 mo, MTT assay showed significant differences in the proportion of adherent viable cells in the FH group and GSH group compared with the control group (p < 0.05), and the FH + H group had a more beneficial effect on post-thaw survival of cryopreserved ADSCs compared with the GSH + H and GSH + FH + H groups. The use of FH and H in long-term storage has the potential to be helpful in com. and clin. application of ADSCs. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7Product Details of 105628-07-7).

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Product Details of 105628-07-7

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem