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A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

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An electrolytic tin alloy plating solution contains a compound serving as a source of supply of tin ions, a compound serving as a source of supply of silver ions, an oxide of a nitrogen-containing heterocyclic compound, and a flavonoid compound.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

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Isoquinoline-3-carboxylic acid (2) was modified with amino acid benzylesters and 18 novel N-isoquinoline-3-carbonylamino acid benzylesters (3a-r) were provided. The IC50 values of 3a-r against the proliferation of HL-60 and Hela cells were less than 1 × 10-8 M and 6 × 10-7 M, respectively. On S180 mice model 100 mumol/kg of 3a-r effectively inhibited the growth of the tumors. Using MFA based Cerius2 QSAR module, two equations (r, 0.989 and 0.987) were established to correlate the structure with the in vitro and in vivo activities. The benefit of this modification was supported with both the in vitro membrane permeation test and the in vivo anti-tumor assay. The in vitro membrane permeability of N-isoquinoline-3-carbonyl-l-threonine benzylester (3n) and N-isoquinoline-3-carbonyl-l-leucine benzylester (3q) was 2.5 fold higher than that of 2, and the in vivo anti-tumor activity of 3n, q was 4.4-fold higher than that of 2.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

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The preparation of t-butylthioethers from examples of halogen substituted heterocycles are described.S-Dealkylation of the t-butylthioethers readily takes place by pyrolyses with catalytic amounts of aluminum chloride or p-toluenesulfonic acid.

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Isoquinoline – Wikipedia,
Isoquinoline | C9H1264N – PubChem

 

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The production of pharmaceuticals usually involves multistep syntheses where the selectivity and yield of the individual steps are of utmost importance. Among highly efficient catalytic processes, carbonylation has gained special attention as it involves both new carbon-carbon bond formation and the introduction of a synthetically useful functionality into the parent molecule. Ambient conditions, high activity of the catalysts, the possibility of tuning selectivities and high functional group tolerance make these reactions versatile tools in the synthesis of carbonyl compounds and carboxylic acid derivatives. The synthetic utility of this methodology is demonstrated by examples from the past 10 years for the application of hydroalkoxycarbonylation of alkenes, carbonylation of aryl/alkenyl halides and oxidative carbonylation reactions for the synthesis of compounds of pharmaceutical interest.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H2077N – PubChem

 

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Biologically active compositions of matter comprising substituted isoquinolines and salts thereof. Certain of the compounds and their salts are novel. Acaricidal, fungicidal, herbicidal and insecticidal activity is demonstrated. In particular 3-chloro-5-acetamido-isoquinoline shows good activity as a selective pre-emergence herbicide, and 4-bromo-5-nitro-isoquinoline shows good fungicidal activity against Erysiphe graminis (wheat powdery mildew).

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Brief introduction of 6,7-Dimethoxy-3,4-dihydroisoquinoline

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The first synthesis of the novel marine alkaloids aaptamine and demethyloxyaaptamine is described, as well as the first synthesis of the parent heterocycle 1H-benzo<1,6>naphthyridine (didemethoxyaaptamine).

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Isoquinoline – Wikipedia,
Isoquinoline | C9H2386N – PubChem

 

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A method for the preparation of tetrazolo[1,5-a]pyridines from 2-halopyridines, utilizing trimethylsilyl azide in the presence of tetrabutylammonium fluoride hydrate, is described. In addition, 8-bromotetrazolo[1,5-a]pyridine is further transformed into a variety of novel tetrazolo[1,5-a]pyridine derivatives. Georg Thieme Verlag Stuttgart.

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

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Palladacycles derived from phenone-oximes 1 are efficient precatalysts for the Suzuki-Miyaura coupling of arylboronic acids with aromatic and heteroaromatic bromides and chlorides under water reflux under aerobic conditions. Alternatively, the coupling can also be carried out at room temperature in methanol-water. Aryl bromides gave biaryls with TON up to 105 and TOF up to 7 × 104 h-1. Activated and deactivated aryl chlorides need the presence of TBAB for the couplings, showing slightly lower efficiency (TON up to 9000 and TOF up to 3850 h-1). C(sp2)-C(sp3) bonds can also be formed by cross-coupling reactions of trimethylboroxine and butylboronic acid with aromatic bromides and chlorides under water reflux and of benzylic and allylic chlorides or acetates with arylboronic acids in acetone-water at room temperature.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

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The phosphorus compound tert-butyl tetraisopropylphosphorodiamidite, prepared from bis(diisopropylamino)chlorophosphine, is an excellent ligand for palladium-catalysed Buchwald-Hartwig amination of aryl- and heteroaryl chlorides and bromides. Based on its ready accessibility and air-stability, this amination protocol is a practical approach to the synthesis of industrially important aryl- and heteroarylamines. Copyright

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H1440N – PubChem