Tag: M.W:200-300

63927-23-1, 5-Bromo-8-nitroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63927-23-1, A suspension of 5-bromo-8-nitro-isoquinoline (2.0 g, 7.93 mmol), triethylamine(1.2 g, 11.90 mmol) and PdVC (10%; 200 mg) in dimethylformamide (10 mL) was hydrogenated at atmospheric pressure for 2 h. The reaction mixture was filtered through Celite and washed with ethyl acetate. The filtrate was concentrated in vacuo to afford isoquinolin-8-amine (700 mg, 66%) as a pale yellow solid.

63927-23-1 5-Bromo-8-nitroisoquinoline 816983, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; F2G LTD; WO2009/130481; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1350643-72-9, (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 100 mg (0.391 mmol) of tert-butyl 4-chloro-5,6-dihydro-7H-pyrrolo [2,3- d] pyrimidine- 7- carboxylate in a 5 mL microwave vial, 129 mg (0.430 mmol) of (S) -3- (1-aminoethyl) -8-chloro-2-phenylisoquinoline-1 (2H) -one obtained in Preparation Example 3 was dissolved in 3 mL of anhydrous toluene , 2.6 mg (0.012 mmol) of palladium (II) acetate (Pd (OAc) 2) 2,2′-bis (diphenylphosphino) -1,1′-binaphthalene ((+ -) – BINAP) 22 mg (0.035 mmol), 178 mg (0.547 mmol) of cesium carbonate (Cs2CO3) was added, and degassing was performed three times using argon gas. And the mixture was stirred at 85 for 15 hours. The reaction mixture was filtered under reduced pressure, and the organic layer was extracted with ethyl acetate and water. The organic layer was dried (Na2SO4), filtered and concentrated. The crude product was dissolved in dichloromethane and purified by column chromatography (SiO2, eluent: hexane – dichloromethane of 33% ethyl acetate) to give tert-butyl (S) -4 – ((1- (8-chloro-1-oxo-2-phenyl-l, 2-dihydroisoquinolin- Yl) ethyl) amino) -5,6-dihydro- 7H-pyrrolo [2,3-d] pyrimidine-7-carboxylate 120 mg (0.469 mmol, 59% yield) was obtained as a pale yellow solid., 1350643-72-9

The synthetic route of 1350643-72-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Korea Research Institute of Chemical Technology; Lee, Gay Hyung; Lim, Hee Jong; Cho, Hee Young; Park, Woo Kyu; Jung, Dae Young; (40 pag.)KR2017/74381; (2017); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215453-51-3,7-Bromo-1-chloroisoquinoline,as a common compound, the synthetic route is as follows.

215453-51-3, 7-Bromo-1-chloroisoquinoline (1-1) (79 mg, 0.327 mmol, 1.0 equiv) and Ethyl carbazate (34 mg, 0.33 mmol, 1.0 equiv) were suspended in EtOH (1.5 mL). The reaction mixture was irradiated in microwave at 170 C. for 40 minutes. The crude mixture was purified with reverse phase HPLC (H2O/CH3CN gradient w/0.1% TFA present) to yield 9-bromo[1,2,4]triazolo[3,4-a]isoquinolin-3(2H)-one (1-2). LRMS m/z (M+H) 263.9 and 264.9 found, 264.1 and 265.1 required.

The synthetic route of 215453-51-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Arrington, Kenneth L.; Brnardic, Edward J.; Dudkin, Vadim Y.; Fraley, Mark E.; Huang, Shaei Y.; Wang, Cheng; US2007/254879; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.

Intermediate compound 3a (315 mg, 0.600 mmol) was dissolved in anhydrous DCM. 5-isoquinoline sulfonyl chloride ¡¤ HCl (190.3 mg, 0.721 mmol) and TEA (100 ml, 0.721 mmol) were added to the mixture, and the mixture was stirred at room temperature for 2 hours.After confirming the completion of the reaction,After acidification with saturated ammonium chloride solution and extraction with DCM,Dried over anhydrous MgSO4,Filtered and rotary evaporated.Purification of the compound was purified by column chromatography (methanol: chloroform = 1: 45) to obtain white crystals; Yield: 54.0%, 105627-79-0

105627-79-0 Isoquinoline-5-sulfonyl chloride hydrochloride 13116932, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Gwangju Institute of Science and Technology; Kim, Yong Chul; Lee, Ka Eun; (33 pag.)KR101732732; (2017); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84468-15-5,Isoquinoline-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

The powdered aryl or heteroaryl sulphonyl chloride (ARYL-SOACI) (1 mmol) was added in small portions to a cooled flask (0 C) containing the ethylene diamine (10 mmol) in dry dichloromethane (20 ml) with vigorous stirring. The reaction was then stirred for 3 hours at room temperature under a nitrogen atmosphere. After checking its conclusion by TLC, the reaction mixture was extracted with 10% aqueous hydrochloric acid solution. After separation of the two resulting phases, the pH of the aqueous layer was adjusted to 10 with a 10% aqueous sodium hydroxide solution and the aqueous layer was extracted with dichloromethane. The organic layer was then dried (anhydrous magnesium sulphate), filtered and evaporated under reduced pressure to give the aryl-sulphonamido-alkylamine as a solid. The aryl or heteroaryl sulphonyl chlorides used in the procedure described above were either obtained from commercial sources or were prepared through reaction of the respective sulphonic acids (2.3 mmol) with thionyl chloride (2.2 ml) in the presence of dimethylformamide (0.3 ml). The reaction was carried out under reflux for 2 hours and, after cooling to room temperature, the reaction mixture was evaporated under reduced pressure to give a solid sulphonyl chloride which was used immediately in the next step., 84468-15-5

The synthetic route of 84468-15-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTEX TECHNOLOGY LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; WO2005/11697; (2005); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147497-32-3,6-Bromo-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

The compound (2.253 g) obtained in Example 17-1 was dissolved in anhydrous THF (11 ml) and added with a 1 mol/l borane-THF complex/THF solution (manufactured by Kanto Chemical Co., Inc.) (55.4ml). The whole was refluxed overnight under heating. After the whole was left for cooling, methanol was added thereto and the solvent was distilled off. The resultant was added with 1 mol/l hydrochloric acid and refluxed under heating for 3 hours. After completion of the reaction, the solution was cooled with ice and added with a 1 mol/l sodium hydroxide aqueous solution and 27% ammonium water, followed by extraction with chloroform. The extract was dried with magnesium sulfate and the solvent was distilled off. The resultant was dissolved in anhydrous dichloromethane (40 ml), added with triethylamine (1.53 ml), and cooled with ice. Trifluoroacetic anhydride (1.55 ml) was added thereto and the whole was stirred at room temperature for 1 hour. After completion of the reaction, the resultant was added with a saturated aqueous sodium hydrogen carbonate solution, subjected to extraction with chloroform, and dried with magnesium sulfate. The solvent was distilled off under reduced pressure, thereby obtaining the subject compound (2.23 g) as a white solid. MS(FAB,Pos.):m/z=308,310[M+H]+, 147497-32-3

147497-32-3 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one 21865450, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Kureha Corporation; EP1724263; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

552331-06-3,552331-06-3, 6-Bromo-3-chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Chloro-6-(pyrimidin-5-yl)isoquinoline Method E A suspension of 6-bromo-3-chloroisoquinoline (62 mg, 0.27 mmol), pyrimidin-5- ylboronic acid (45 mg, 0.36 mmol), Pd(PPh3)4 (29.5 mg, 0.026 mmol) and CsF (1 17 mg, 0.77 mmol) in DME/MeOH (3/1 mL) was stirred at 150 X1 under microwave irradiation for 30 minutes. The reaction mixture was filtered and concentrated in vacuo. The residue was purified using Biotage silica gel column chromatography eluting with between 20- 60% EtOAc in cyclohexane to afford the title compound (26 mg, 42%). 1 H NMR (500 MHz, CDCI3): delta 9.32 (s, 1 H), 9.17 (s, 1 H), 9.09 (s, 2H), 8.16 (dt, J = 8.5, 0.9 Hz, 1 H), 7.98 (dd, J = 1 .8, 0.9 Hz, 1 H), 7.88 – 7.78 (m, 2H). LCMS (ESI) Rt = 2.14 minutes MS m/z 242 [M+H]+

As the paragraph descriping shows that 552331-06-3 is playing an increasingly important role.

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; HOELDER, Swen; BLAGG, Julian; CHEUNG, Jack; ATRASH, Butrus; SHELDRAKE, Peter; WO2014/37751; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

13130-79-5, 1-Bromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-biphenylacetic acid (1. [0G,] 4.7 [MMOL)] in 10 mi of anhydrous DMF was added HBTU (2.1g, 5.7 [MMOL)] and 1.0 ml of DIEA. The mixture was stirred at room temperature for 10 min, and then 1-bromo-3-isoquinolinamine (0.68g, 4.7 [MMOL)] was added. After stirring over night, the mixture was poured into water, acidified with 10% citric acid, and extracted with ethyl acetate. The organic extracts were washed with water and brine, dried over [NA2SO4.] After the condensation of the solvent, the residue was purified by flash column chromatography [(SIO2,] 1: [1] hexane: ethyl aceate) to provide the title compound (1.7g, 86%) as a light yellow solid. ‘H-NMR (400 MHz, [CDC . S)] : 3.83 (s, 3H), 7.33-7. 37 (m, 1H), 7.42-7. 48 (m, 4H), 7.52- 7.58 (m, 1 H), 7.60-7. 64 (m, 4H), 7.65-7. 70 (m, 1 H), 7.80 (d, 1 H,), 7. [61] (s, 1H), 8.18 (d, 1 H), 8.56 (s, 1H) ; LC/MS (m/z) : 418 (M+1) [+.]

13130-79-5, 13130-79-5 1-Bromoisoquinolin-3-amine 289845, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; TRANSTECH PHARMA, INC.; WO2004/14844; (2004); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

84468-15-5, Isoquinoline-5-sulfonyl chloride is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0517] Procedure: To a stirred solution of compound isoquinoline-5-sulfonyl chloride (0.5 g, 2.192 mmol) in tetrahydrofuran (10 mL) at 0C was added ammonium hydroxide solution (0.26 mL, 6.578 mmol) and stirred for 1.5 h at room temperature. The progress of the reaction was monitored by TLC. Then the reaction was quenched with water (10 mL) and extracted with 5% methanol in dichloromethane (3 ¡Á 50 mL), combined organic layers were washed with water (10 mL) and brine (10 mL). The organic layer was dried over sodium sulphate, filtered and evaporated under reduced pressure, purified by combiflash purifier using 8% methanol in dichloromethane to afford isoquinoline-5-sulfonamide (0.35 g, 76% (2 Steps)) as off-white solid.1HNMR (400 MHz, DMSO-d6): delta 9.45 (s, 1H), 8.66 (d, J =5.6 Hz, 1H), 8.42-8.32 (m, 3H), 7.82-7.78 (m, 1H), 7.74 (s, 2H). LC-MS m/z = 209.1 [M+H]+.

84468-15-5, The synthetic route of 84468-15-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MAVUPHARMA, INC.; GALLATIN, William Michael; ODINGO, Joshua; DIETSCH, Gregory N.; FLORIO, Vincent; VENKATESHAPPA, Chandregowda; DURAISWAMY, Athisayamani Jeyaraj; (273 pag.)WO2019/46778; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.891785-28-7,6-Bromoisoquinolin-3-amine,as a common compound, the synthetic route is as follows.

891785-28-7, To an oven dried schlenck flask was added [(2R)-tetrahydrofuran-2-ylj-[4-[4-(4,4,5,5- tetramethyl- 1,3 ,2-dioxaborolan-2-yl)phenoxyj -1 -piperidylj methanone (0.11 g, 0.26 mmol), 6- bromoisoquinolin-3-ylamine (0.09 g, 0.39 mmol), tetrakis(triphenylphosphine)palladium(0) (0.03 g, 0.03 mmol), iN Na2CO3 (0.79 mL, 0.79 mmol), followed by i,4-dioxane (2 mL) and was degassed under an atmosphere of argon for 5 mm and was heated at 99 C for 2 h. The reaction was cooled, filtered through a pad of celite, washed with iN Na2CO3/water/brine, dried over sodium sulfate, and concentrated. The product was purified using the Gilson (0. i%TFA in water/0. 1% TFA in acetonitrile gradient), diluted clean fractions with DCM, washed with iN Na2CO3/brine, dried over sodium sulfate, and concentrated. {4-[4-(3-aminoisoquinolin-6-yl)- phenoxyj-piperidin-i-yl}-(R)-tetrahydrofuran-2-yl-methanone was isolated as a solid (0.04 g, 34%). Analysis: LCMS m/z = 403 (M+i). ?H NMR (DMSO-d6) oe: 8.78 (s, iH), 7.84 (d, iH, J =8.6 Hz), 7.70 (m, 3H), 7.44 (m, 2H), 7.11 (m, 2H), 6.65 (s, iH), 5.91 (s, 2H), 4.68 (m, 2H), 3.76 (m, 4H), 3.41 (m, iH), 3.29 (m, iH), 2.01 (br m, 4H), i.84 (m, 2H) i.5i-i.65 (br m, 2H).

891785-28-7 6-Bromoisoquinolin-3-amine 45789831, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; CEPHALON, INC.; BECKNELL, Nadine, C.; DANDU, Reddeppa, Reddy; DORSEY, Bruce, D.; GOTCHEV, Dimitar, B.; HUDKINS, Robert, L.; WEINBERG, Linda; ZIFICSAK, Craig, A.; ZULLI, Allison, L.; (411 pag.)WO2016/205633; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem