Category: 104-01-8

Sokolov, Anatolii I. published the artcileConvenient and Versatile Synthetic Protocol for Arylidene-1H-imidazol-5(4H)-ones, Computed Properties of 104-01-8, the main research area is arylacetamidoacetate alkylimino benzylidene alkylation diastereoselective cycloaddition; aryl benzylidene alkylimidazolone preparation; benzylidene benzoyl methylimidazolone preparation.

A new protocol for synthesis of the arylidene-1H-imidazol-5(4H)-ones based on O-alkylation of amidoacetates using triethyloxonium tetrafluoroborate leading to carboximidates was proposed. These imidates have long been used in the synthesis of imidazolones by [2+3] cycloaddition reaction with Schiff bases. However, diversity of carboximidates prepared by the common techniques was limited. The protocol proposed here eliminated these limitations. Using this technique, a number of derivatives of the green fluorescent protein (GFP) and as FP chromophores were synthesized, and influence of the C2 residue on their optical properties was studied.

ChemistrySelect published new progress about Alkylation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zeng, Qian published the artcileCopper-catalyzed carbene/alkyne metathesis terminated with the Buchner reaction: synthesis of dihydrocyclohepta[b]indoles, Computed Properties of 104-01-8, the main research area is aminophenylpropynyl diazophenylacetate copper tandem carbene alkyne metathesis Buchner reaction; cycloheptaindolyl phenylfuranone regioselective preparation.

A copper-catalyzed selective cascade reaction of alkyne-tethered diazo compounds was reported for the direct and efficient construction of dihydrocyclohepta[b]indole skeletons under mild reaction conditions. A vinyl copper carbene was the key intermediate, which was generated in-situ via carbene/alkyne metathesis (CAM) and terminated with the Buchner reaction.

Organic & Biomolecular Chemistry published new progress about Alcohols, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Biswas, Nandita published the artcileRu-Catalyzed Selective Catalytic Methylation and Methylenation Reaction Employing Methanol as the C1 Source, Safety of 4-Methoxyphenylacetic acid, the main research area is methylated compound green preparation; phenylethanol methanol methylation ruthenium catalyst; naphthol methanol methylation ruthenium catalyst; amine methanol methylation ruthenium catalyst.

The activity of the acridine-derived SNS-Ru pincer for the activation of methanol to apply it as a C1 building block in different reactions was explored. Catalytic system showed great success toward the β-C(sp3)-methylation reaction of 2-phenylethanols to provide good to excellent yields of the methylated products RCH(CH3)CH2OH [R = Ph, 4-FC6H4, 2-thienyl, etc.]. The mechanistic details, kinetic progress and temperature-dependent product distribution, which revealed the slow and steady generation of in situ formed aldehyde, was the key factor to get the higher yield of the β-methylated product. To establish the environmental benefit of this reaction, green chem. metrics were calculated Furthermore, dimerization of 2-naphthol via methylene linkage to obtain methylated products I [R1 = H, 3-MeO, 6-Ph, etc.] and formation of N-methylation of amine were also described in this study, which offers a wide range of substrate scope with a good to excellent yield of methylated products R2NHCH3 [R2 = (CH2)7CH3, Ph, 2-BrC6H4, etc.].

Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Ya-Lan published the artcileChemo- and Site-Selective Fischer Esterification Catalyzed by B(C6F5)3, Category: isoquinoline, the main research area is ester preparation chemoselective; carboxylic acid alc Fischer esterification tris pentafluorophenyl borane catalyst.

A direct and catalytic dehydrative esterification of carboxylic acids RC(O)OH [R = hept-1-yn-1-yl, 2-(naphthalen-2-yl)ethyl, (1-methyl-1H-indol-3-yl)methyl, 1-([(benzyloxy)carbonyl]amino)ethyl, etc.] with alcs. R1OH (R1 = Et, cyclohexyl, 2,3-dihydroxypropyl, etc.) is described. B(C6F5)3 is shown to be a highly effective catalyst for the Fischer esterification, providing esters RC(O)OR1 in high to excellent yields. This esterification shows excellent chemo- and site-selective monoesterification of various polyols R1OH without any protection step, including bio-derived mol. glycerol.

Asian Journal of Organic Chemistry published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hirbawi, Nadia published the artcileHalogenation Reactions of Alkyl Alcohols Employing Methyl Grignard Reagents, Synthetic Route of 104-01-8, the main research area is alkyl halide preparation; alc alkyl Grignard reagent halogenation.

Herein, an example of Grignard reagents acting as halide nucleophiles to form alkyl iodides RI [R = 1-(4-methoxyphenyl)-5-phenylpentan-3-yl, 4-phenylbutan-2-yl, 4-(2H-1,3-benzodioxol-5-yl)butan-2-yl, etc.] and alkyl bromides R1Br [R1 = 3-[4-(3-methoxyphenyl)phenyl]propyl, 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl, 3-(4-bromophenyl)propyl, etc.] was reported. This work establishes that Grignard reagents can convert alkyl mesylates ROMs/R1OMs into alkyl halides RI/R1Br, as well as be employed in a one-pot halogenation reaction starting from alcs. ROH/R1OH, which proceed through mesylate intermediates. The halogenation reaction is confirmed to occur by an SN2 pathway with the inversion of configuration and is demonstrated to be efficient on a gram scale.

Journal of Organic Chemistry published new progress about Bromoalkanes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Felicetti, Tommaso published the artcileSustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents, Product Details of C9H10O3, the main research area is pyridobenzothiazolone preparation antiflaviviral NS5 polymerase inhibition Dengue Zika antitumor; Antiviral agents; Dengue inhibitors; NS5 polymerase; One-pot procedure; Three-component reaction (3CR); Zika inhibitors.

The development of a new and sustainable three-component reaction (3CR) that can be combined with a basic hydrolysis in a one-pot procedure has been reported to obtain the pyridobenzothiazole (PBTZ) scaffold, thus reducing the number of synthetic steps, improving yields and saving time. 3CR was significantly explored in order to demonstrate its wide scope by using different starting materials. Taking advantage of these procedures, a new set of PBTZ analogs was synthesized and tested as anti-DENV-2 and anti-ZIKV agents. Compound I inhibited DENV-2 NS5 polymerase with an IC50 of 10.4μM and represented the best anti-flavivirus compound of the new series by inhibiting DENV-2- and ZIKV-infected cells with EC50 values of 1.2 and 5.0μM, resp., that translates into attractive selectivity indexes (SI – 83 and 20, resp.). These results strongly reaffirm PBTZ derivatives as promising anti-flavivirus agents that now can be synthesized through a convenient and sustainable 3CR in order to obtain more potent compounds for further pre-clin. development studies.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Stivanin, Mateus L. published the artcileBlue Light-Promoted N-H Insertion of Carbazoles, Pyrazoles and 1,2,3-Triazoles into Aryldiazoacetates, Application of 4-Methoxyphenylacetic acid, the main research area is carbazole diazophenylacetate photochem insertion reaction; carbazolyl phenylacetate preparation; pyrazole diazophenylacetate photochem regioselective insertion reaction; pyrazolyl phenylacetate preparation; triazole diazophenylacetate photochem regioselective insertion reaction; triazolyl phenylacetate preparation.

Blue light irradiation of aryldiazoacetates led to the formation of free carbenes, which reacted with carbazoles, pyrazoles and 1,2,3-triazoles to afford the corresponding N-H inserted products. These reactions were performed under air and at room temperature, allowing the mild preparation of a variety of motifs found in biol. relevant targets.

Advanced Synthesis & Catalysis published new progress about Carboxylic acids, alkyl esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shishlikova, Maria A. published the artcileDirected Synthesis of Regioisomeric Monoaryl-Substituted Pyridines Containing a Tricyanobutadiene Fragment and Study on Their Optical Properties, Category: isoquinoline, the main research area is tricyanobutadieyl pyridine preparation regioselective optical study; chlorocinnamaldehyde malononitrile dimer heterocyclization; arylmalondialdehyde malononitrile dimer heterocyclization; enaminoketone malononitrile dimer heterocyclization.

A series of regioisomeric monoaryl-substituted pyridines I (Ar = H, Ph, 4-methoxyphenyl, 3,4-dimethoxyphenyl; Ar1 = H, Ph, 4-methoxyphenyl, 3,4-dimethoxyphenyl; Ar2 = H, Ph, 4-methoxyphenyl, 3,4-dimethoxyphenyl) containing a tricyanobutadiene fragment was prepared using modified known and novel developed synthetic approaches. Advantages and limitations of the used methods were discussed. Dependence of the optical absorption and emission characteristics on the position of aromatic substituent was studied. An unusual intramol. charge transfer from malononitrile fragment to the pyridine ring was found, which was consistent with observed exptl. and theor. data.

ChemistrySelect published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pan, Zhangjin published the artcilePalladium/TY-Phos-Catalyzed Asymmetric Intermolecular α-Arylation of Aldehydes with Aryl Bromides, Computed Properties of 104-01-8, the main research area is arylated aldehyde preparation enantioselective; aldehyde aryl bromide arylation palladium catalyst; Z/E-enolates; acyclic aldehydes; all-carbon quaternary centers; asymmetric catalysis; α-arylation.

Herein, an efficient Pd-catalyzed asym. intermol. α-arylation reaction of α-alkyl-α-aryl disubstituted aldehydes with aryl bromides, which provided a rapid access to chiral aldehydes bearing an α-all-carbon quaternary stereocenter in moderate to good yields with good er in most cases was reported. In addition, a pair of enantiomers could be easily prepared with the use of the same ligand by exchanging the aryl groups of aldehyde and aryl bromide.

Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Mu-Yi published the artcilePd-Catalyzed Selective Chlorination of Acrylamides at Room Temperature, Category: isoquinoline, the main research area is palladium catalyzed stereoselective chlorination acrylamide.

In this Letter, the transition-metal-catalyzed chlorination of alkenes is reported. In the presence of the com. available and inexpensive N-chlorosuccinimide and without additive, the Pd-catalyzed chlorination of acrylamides by C-H bond activation was developed at room temperature under air. Under these mild reaction conditions, the versatility of the methodol. was demonstrated as an array of acrylamides was functionalized to selectively provide the corresponding difficult-to-synthesize chlorinated olefins as a single Z stereoisomer. Mechanistic studies were conducted to get insights into the reaction mechanism, and post-functionalization reactions further demonstrated the synthetic utility of the approach toward the access to high value-added chlorinated compounds

Organic Letters published new progress about C-H bond activation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem