Category: 104-01-8

Hsu, Wei-Hsiang published the artcileASIC3-dependent metabolomics profiling of serum and urine in a mouse model of fibromyalgia, Computed Properties of 104-01-8, the main research area is fibromyalgia ASIC3 metabolomics profiling biomarker.

Fibromyalgia (FM) is characterized by chronic widespread pain. Here, we probed the metabolomics profiles of serum and urine in a mouse model of FM induced by intermittent cold stress (ICS). We focused on the role of acid-sensing ion channel 3 (ASIC3) in the metabolomics profiling because ICS treatment induced chronic widespread muscle pain lasting for 1 mo in wild-type (Asic3+/+) but not Asic3-knockout (Asic3-/-) mice. Serum and urine samples were collected from both genotypes at different ICS stages, including before ICS (basal level) and post-ICS at days 10 (middle phase, P10) and 40 (recovery phase, P40). Finally, we developed an algorithm for the impactful metabolites in the FM model including cis-aconitate, kynurenate, taurine, pyroglutamic acid, pyrrolidonecarboxylic acid, and 4-methoxyphenylacetic acid in urine as well as carnitine, deoxycholic acid, lysoPC(16:0), lysoPC(20:3), oleoyl-L-carnitine, and trimethylamine N-oxide in serum. Asic3-/- mice were impaired in only muscle allodynia development but not other pain symptoms in the ICS model, so the ASIC3-dependent metabolomics changes could be useful for developing diagnostic biomarkers specific to chronic widespread muscle pain, the core symptom of FM. Further pharmacol. validations are needed to validate these metabolomics changes as potential biomarkers for FM diagnosis and/or treatment responses.

Scientific Reports published new progress about Biomarkers. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Sheng published the artcileCobalt(II)-Catalyzed Stereoselective Olefin Isomerization: Facile Access to Acyclic Trisubstituted Alkenes, Formula: C9H10O3, the main research area is cobalt catalyst stereoselective olefin isomerization; acyclic trisubstituted alkenes stereoselective preparation.

Stereoselective synthesis of trisubstituted alkenes is a long-standing challenge in organic chem., due to the small energy differences between E and Z isomers of trisubstituted alkenes (compared with 1,2-disubstituted alkenes). Transition metal-catalyzed isomerization of 1,1-disubstituted alkenes can serve as an alternative approach to trisubstituted alkenes, but it remains underdeveloped owing to issues relating to reaction efficiency and stereoselectivity. Here we show that a novel cobalt catalyst can overcome these challenges to provide an efficient and stereoselective access to a broad range of trisubstituted alkenes. This protocol is compatible with both mono- and dienes and exhibits a good functional group tolerance and scalability. Moreover, it has proven to be a useful tool to construct organic luminophores and a deuterated trisubstituted alkene. A preliminary study of the mechanism suggests that a cobalt-hydride pathway is involved in the reaction. The high stereoselectivity of the reaction is attributed to both a π-π stacking effect and the steric hindrance between substrate and catalyst.

Journal of the American Chemical Society published new progress about Diastereoselective synthesis. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhou, Leijie published the artcilePhosphine-Catalyzed Asymmetric Tandem Isomerization/Annulation of Allyl Amines with Allenoates: Enantioselective Annulation of a Saturated C-N Bond, Computed Properties of 104-01-8, the main research area is pyrroline preparation enantioselective DFT; allylamine allenoate asym tandem isomerization heterocyclization chiral phosphine catalyst.

Under catalysis by chiral phosphine, an asym. isomerization/annulation cascade reaction of allylamines ArSO2NHCH2CH=CHC(O)OCH2CH3 (Ar = Ph, 4-nitrophenyl, 4-methylphenyl) with allenoates RCH=C=CHC(O)O2CH3 (R = Me, cyclopropyl, 4-methoxyphenyl, etc.) was realized. A wide range of γ-substituted allenoates were tolerated to afford chiral pyrroline derivatives I in high yields with excellent enantioselectivities. In the reaction, isomerization of readily available N-allylamines to reactive aliphatic imines through a 1,4-proton shift is a key step, which circumvents the isolation of highly unstable alkyl N-sulfonylimines.

Organic Letters published new progress about Allyl amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Haoqi published the artcileSynthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization, Application In Synthesis of 104-01-8, the main research area is cyclic amidinium triflate preparation; oxazine preparation; amide azide cyclization.

Herein, we report a metal-free synthesis of cyclic amidines, oxazines, and an oxazinone under mild conditions by electrophilic amide activation. This strategy features an unusual Umpolung cyclization mode and enables the smooth union of α-aryl amides and diverse alkylazides, effectively rerouting our previously reported α-amination transform.

Organic Letters published new progress about Azides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Guoqiang published the artcileMigrative Carbofluorination of Saturated Amides Enabled by Pd-Based Dyotropic Rearrangement, Formula: C9H10O3, the main research area is functionalized amide preparation; saturated amide dyotropic rearrangement migrative carbofluorination palladium catalyst.

Herein, a palladium-catalyzed migrative carbofluorination of saturated amides enabled by the activation of both the C(sp3)-H and the Cquaternary-Cσ bonds was reported for the synthesis of functionalized amides. In this transformation, the α-quaternary carbon of Weinreb amides was converted to α-tertiary fluoride with concurrent migration of an aryl or an amido group from the α- to β-carbon. DFT calculations indicate that the dyotropic rearrangement proceeds through an unusual anti-selective [2.1.0] bicyclic transition state.

Journal of the American Chemical Society published new progress about Fluorination. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Zekun published the artcilePhotoredox Catalyzed Sulfonylation of Multisubstituted Allenes with Ru(bpy)3Cl2 or Rhodamine B, Formula: C9H10O3, the main research area is methyl phenylpropenyl sulfonylbenzene diastereoselective regioselective preparation; multisubstituted allene toluenesulfonic acid sulfonylation ruthenium photoredox catalyst; ethyl phenyl tosylbutenoate diastereoselective regioselective preparation; allenic ester toluenesulfonic acid rhodamine B photoredox catalyst sulfonylation.

A highly regio- and stereoselective sulfonylation of allenes was developed that provided direct access to α,β-substituted unsaturated sulfones I [R1 = Ph, 4-ClC6H4, 4-MeC6H4, etc.; R2 = H, Ph; R3 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R4 = Me, CH2C(O)OEt]. By means of visible-light photoredox catalysis, the free radicals produced by p-toluenesulfonic acid reacted with multisubstituted allenes to obtain Markovnikov-type vinyl sulfones with Ru(bpy)3Cl2 or Rhodamine B as photocatalyst. The yield of this reaction could reach up to 91%. A series of unsaturated sulfones would be used for further transformation to some valuable compounds

Journal of Organometallic Chemistry published new progress about Allenes Role: SPN (Synthetic Preparation), PREP (Preparation) (aryl). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Luo, Xiai published the artcilePalladium-Catalyzed Domino Heck/C-H Activation/Decarboxylation: A Rapid Entry to Fused Isoquinolinediones and Isoquinolinones, Category: isoquinoline, the main research area is fused isoquinolinedione isoquinolinone preparation regioselective; alkene aryl iodide bromobenzoic acid domino cyclization palladium catalyst; carbon hydrogen activation Heck reaction decarboxylation.

A new palladium-catalyzed tandem cyclization of various alkene-tethered aryl iodides has been presented. In this protocol, o-bromobenzoic acids are employed as coupling parters to achieve the insertion of aromatic rings by the cleavage of C(sp2)-Br and decarboxylation, thus assembling various dibenzoisoquinolinediones and dibenzoisoquinolinones. In addition, a seven-membered ring can be constructed by the use of 8-bromo-1-naphthoic acid. Notably, this approach enables regioselective product formation and features broad substrate scope.

Organic Letters published new progress about Aryl iodides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkene-tethered). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Shuai published the artcileElectrochemical aziridination of tetrasubstituted alkenes with ammonia, Application of 4-Methoxyphenylacetic acid, the main research area is aziridine preparation; alkene ammonia electrochem aziridination.

Ammonia (NH3) is an ideal nitrogen source in terms of availability, reactivity, safety, atom economy, environmental compatibility, and ease of isolation. However, its utility for amine synthesis is limited by its high bond dissociation energy, its strong coordination ability, and the difference between its reactivity and that of the product amines. Herein, authors reported the first electrochem. protocol for direct syntheses of unprotected tetrasubstituted aziridines with NH3 and alkenes in the absence of an oxidant, which are highly challenging to achieve by other methods. The combination of graphite felt as the anode material and MeOH as the solvent was the key to the success of the protocol, and the effects of these factors were investigated by means of cyclic voltammetry and d. functional theory calculations

CCS Chemistry published new progress about Aziridination. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ma, Biao published the artcileEfficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)-Catalyzed C-H Activation/Carbene Insertion/Lossen Rearrangement Sequence, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is olefin diazo oxindole rhodium catalyst domino annulation bond activation; spirooxindole pyrrolone preparation; carbene insertion Lossen rearrangement nucleophilic addition; C−H activation; Lossen rearrangement; olefins; oxindoles; rhodium catalysis.

A rhodium(III)-catalyzed domino annulation of simple olefins with diazo oxindoles to give spirooxindole pyrrolone products is described. This reaction can be formally viewed as the result of an anomalous tandem C-H activation, carbene insertion, Lossen rearrangement, and a nucleophilic addition process. The potential utility of this reaction was further demonstrated by the late-stage diversification of drug mols.

Angewandte Chemie, International Edition published new progress about C-H bond activation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Feng, Yunxia published the artcileIntermolecular alkene arylcyanation using BnSCN as a cyanide source via a reductive strategy: access to 3,3-disubstituted oxindoles, Application of 4-Methoxyphenylacetic acid, the main research area is oxindole preparation; alkene benzyl thiocyanate reductive intermol arylcyanation nickel catalyst.

Herein, a nickel-catalyzed two-component reductive arylcyanation of aryl (pseudo)halide tethered alkenes using benzyl thiocyanate as the cyanide source via C-S bond activation is developed. Using this protocol, a wide scope of 3,3-disubstituted oxindoles bearing all-carbon quaternary stereocenters are accessible in moderate to excellent yields. The preliminary mechanistic investigations reveal that a Ni(I)/Ni(III) process might be involved in the mechanism.

Organic Chemistry Frontiers published new progress about Cyanation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem