Ma, Biao published the artcileEfficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)-Catalyzed C-H Activation/Carbene Insertion/Lossen Rearrangement Sequence, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is olefin diazo oxindole rhodium catalyst domino annulation bond activation; spirooxindole pyrrolone preparation; carbene insertion Lossen rearrangement nucleophilic addition; C−H activation; Lossen rearrangement; olefins; oxindoles; rhodium catalysis.
A rhodium(III)-catalyzed domino annulation of simple olefins with diazo oxindoles to give spirooxindole pyrrolone products is described. This reaction can be formally viewed as the result of an anomalous tandem C-H activation, carbene insertion, Lossen rearrangement, and a nucleophilic addition process. The potential utility of this reaction was further demonstrated by the late-stage diversification of drug mols.
Angewandte Chemie, International Edition published new progress about C-H bond activation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem