Day: November 30, 2022

Guo, Zhiqiang published the artcileCO2-tuned highly selective reduction of formamides to the corresponding methylamines, Name: 4-Methoxy-N-methylaniline, the main research area is tertiary amine preparation; methylated formamide reduction carbon oxygen bond cleavage dioxide.

Herein an efficient, CO2-tuned and highly selective C-O bond cleavage of N-methylated formanilides is described. With easy-to-handle and com. available NaBH4 as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO2 has been investigated in detail, and the mechanism is proposed on the basis of experiments

Green Chemistry published new progress about C-O bond cleavage. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Name: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Huan published the artcileExperimental and Computational Studies of the Iron-Catalyzed Selective and Controllable Defluorosilylation of Unactivated Aliphatic gem-Difluoroalkenes, Quality Control of 1205-17-0, the main research area is fluoroalkene defluorosilylation iron catalysis silylalkene preparation stereoselective DFT; optimized mol structure fluoroalkene defluorosilylation iron catalyst silylalkene preparation; C−F bond cleavage; gem-disilylated alkenes; high selectivity; iron catalysis.

The 1st Fe-catalyzed defluorosilylation of unactivated gem-difluoroalkenes was developed, delivering gem-disilylated alkenes and (E)-silylated alkenes with excellent efficiency. This protocol features good functional group compatibility and excellent regio- and stereoselectivity, enabling the late-stage silylation of biol. relevant compounds, thus providing good opportunities for applications in medicinal chem. Preliminary mechanistic studies and DFT calculations reveal that a nucleophilic addition and elimination of the 2nd C-F bond might be involved in the disilylation catalytic system, demonstrating unusual reactivity characteristics of Fe catalysis.

Angewandte Chemie, International Edition published new progress about C-F bond cleavage. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Quality Control of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Yu-Ting published the artcileFlame retardant and hydrophobic cotton using a unique phosphorus-nitrogen-silicon-containing coating, Computed Properties of 1455-77-2, the main research area is phosphorus nitrogen silicon flame retardant hydrophobic cotton coating.

Phosphorus-nitrogen-silicon-containing coatings consisting of tris(hydroxymethyl)phosphine oxide (THPO), 3,5-diamino-1,2,4-triazole (guanazole) and polydimethylsiloxane (PDMS) were prepared via a simple spraying deposition technique and applied to the cotton fabric to impart flame retardancy and hydrophobicity. SEM image reveals that THPO/Guanazole/PDMS-coated fabric has a rough surface and XPS spectra confirm the composition of the coating on the cotton surface. Direct flame testing indicates that the as-prepared coating can protect the cotton from burning. The limiting oxygen index increased from 18.0% for the uncoated fabric to 32.0% for the THPO/Guanazole-treated sample and 27.0% for the THPO/Guanazole/PDMS-treated sample. Furthermore, with addnl. THPO/Guanazole, there was a gradual reduction in PHRR values, 60% (79.0 kW/m2) for C2 and 76% (48.2 kW/m2) for C3 lower than that of untreated cotton. After hydrophobic treatment of C2 with PDMS, the PHRR is reduced to 127.5 kW/m2 (35.5% for C2-PDMS). Addnl., the coated cotton displays impressive hydrophobicity with a water contact angle of 133°. This unique approach provides a facile and effective flame retardant and hydrophobic treatment for cotton fabric.

Cellulose (Dordrecht, Netherlands) published new progress about Breaking strength. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Computed Properties of 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Yu-Ting published the artcileFlame retardant and hydrophobic cotton using a unique phosphorus-nitrogen-silicon-containing coating, Computed Properties of 1455-77-2, the main research area is phosphorus nitrogen silicon flame retardant hydrophobic cotton coating.

Phosphorus-nitrogen-silicon-containing coatings consisting of tris(hydroxymethyl)phosphine oxide (THPO), 3,5-diamino-1,2,4-triazole (guanazole) and polydimethylsiloxane (PDMS) were prepared via a simple spraying deposition technique and applied to the cotton fabric to impart flame retardancy and hydrophobicity. SEM image reveals that THPO/Guanazole/PDMS-coated fabric has a rough surface and XPS spectra confirm the composition of the coating on the cotton surface. Direct flame testing indicates that the as-prepared coating can protect the cotton from burning. The limiting oxygen index increased from 18.0% for the uncoated fabric to 32.0% for the THPO/Guanazole-treated sample and 27.0% for the THPO/Guanazole/PDMS-treated sample. Furthermore, with addnl. THPO/Guanazole, there was a gradual reduction in PHRR values, 60% (79.0 kW/m2) for C2 and 76% (48.2 kW/m2) for C3 lower than that of untreated cotton. After hydrophobic treatment of C2 with PDMS, the PHRR is reduced to 127.5 kW/m2 (35.5% for C2-PDMS). Addnl., the coated cotton displays impressive hydrophobicity with a water contact angle of 133°. This unique approach provides a facile and effective flame retardant and hydrophobic treatment for cotton fabric.

Cellulose (Dordrecht, Netherlands) published new progress about Breaking strength. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Computed Properties of 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shen, Qing published the artcileVolatile compounds and antioxidant properties of pickled and dried mustard as influenced by different cooking methods, Synthetic Route of 21834-92-4, the main research area is pickled dried mustard volatile compound antioxidant steaming boiling microwaving.

Pickled and dried mustard (PDM; Brassica juncea, Coss), a traditional fermented vegetable product, is very popular in China because of its typical aromatic flavor and great antioxidant activity. PDM is usually consumed after being cooked by various cooking methods. Here, we determined and compared the effects of four different common cooking methods (steaming, high-pressure steaming, boiling, and microwaving) with different cooking time on the volatile compounds and antioxidant properties of PDM. The gas chromatog.-mass spectrometry results showed that steaming for 15 min and high-pressure steaming for 5 min significantly increased the concentration of volatile compounds of PDM while boiling and microwaving obviously decreased them. Moreover, high-pressure steaming best preserved the antioxidant activity, obtained from ABTS, DPPH, FRAP, and ORAC assays, as well as the total phenolic, flavonoid, and glucosinolate content of PDM. These findings provide insights into the beneficial effects of high-pressure steaming for 5 min in cooking PDM. Practical applications : Our findings showed that high-pressure steaming for short time (5 min) was the best way to cook PDM because it could not only significantly increase volatile compounds of PDM but also had the preservation effects of antioxidant activity of PDM. By contrast, boiling and microwaving dramatically decreased the volatile compounds and antioxidant properties of PDM mainly because of leaching action. These findings provide useful information for food producers and consumers to optimize the processing and cooking of PDM products with better flavor and health-related characteristics.

Journal of Food Processing and Preservation published new progress about Boiling (cooking). 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Synthetic Route of 21834-92-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hao, Yining published the artcileEffect of static-state fermentation on volatile composition in rapeseed meal, Safety of 4-Methoxy-N-methylaniline, the main research area is rapeseed meal volatile composition static state fermentation; Tetramethylpyrazine; fermentation; rapeseed meal; volatile components.

BACKGROUND : Fermented rapeseed meal has been used as an alternative protein source for animal feed, but the volatile compounds and how their contents change during fermentation have not been reported. To clarify the effect of static-state fermentation on its aroma, the volatile compounds of rapeseed meal during different stages of fermentation were analyzed using an electronic nose system and headspace solid-phase microextraction-gas chromatog.-mass spectrometry. RESULTS : The results suggested that the volatile compounds in the raw rapeseed meal, mostly hydrocarbons and some aldehydes, were lost. The levels of the volatile compounds resulting from microbial metabolism, especially pyrazines, greatly increased during fermentation Nonanal was the dominant volatile measured in the headspace of raw rapeseed meal. However, the volatile compounds found at high concentrations in rapeseed meal after 5 days of fermentation were tetramethylpyrazine, followed by butanoic acid, benzenepropanenitrile, 2-methylbutanoic acid, trimethylamine, 2,3,5-trimethyl-6-ethylpyrazine, and 2,3,5-trimethylpyrazine. CONCLUSION : The fermentation process could significantly change the composition and content of volatile compounds in rapeseed meal. The results may provide reference data for studies on the choice of fermentation period and formation mechanism of flavor substances in fermented rapeseed meal.

Journal of the Science of Food and Agriculture published new progress about Bacillus subtilis. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Theansungnoen, Tinnakorn published the artcilePhytochemical Analysis and Antioxidant, Antimicrobial, and Antiaging Activities of Ethanolic Seed Extracts of Four Mucuna Species, HPLC of Formula: 598-50-5, the main research area is Mucuna seed extract phytochem analysis antioxidant antimicrobial antiaging activity.

The investigation into promising botanical materials for natural cosmetics is expanding due to environmental and health awareness. Here, we aimed to evaluate the phytochem. substances and the potential skin-related pharmacol. activities of four Mucuna seeds, namely M. gigantea (Willd.) DC. (MGG), M. interrupta Gagnep. (MIT), M. monosperma Wight (MMM), and M. pruriens (L.) DC. (MPR), belonging to the Fabaceae family. In methodol., the Mucuna seeds were authenticated using morphol. and mol. approaches. L-DOPA, phenolics, and flavonoid content, incorporated with HPLC and GC-MS fingerprinting analyses, were determined Then, skin-related antimicrobial, antioxidant, and antiaging activities were determined The results revealed that MPR showed the highest L-DOPA content (75.94 mg/100 mg extract), whereas MGG exhibited the highest phenolic and flavonoid content (56.73 ± 0.62 mg gallic/g extract and 1030.11 ± 3.97 mg quercetin/g extract, resp.). Only MMM and MPR could inhibit all of S. aureus, S. epidermidis, and C. albicans, but no sample could inhibit C. acnes. Furthermore, all samples demonstrated antioxidant activity. Interestingly, all Mucuna samples exhibited strong collagenase, elastase, and hyaluronidase inhibitory activities. We conclude that the ethanolic extracts of four Mucuna seeds are probably advantageous in the development of skincare cosmeceutical products.

Cosmetics published new progress about Anti-aging agents. 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, HPLC of Formula: 598-50-5.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hwangbo, Nathan published the artcilePredictive Modeling of Alzheimer′s and Parkinson′s Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid, Name: 4-Methoxyphenylacetic acid, the main research area is cerebrospinal fluid metabolomic lipidomic profile Alzheimers Parkinsons disease; biomarker; cerebrospinal fluid; cross-sectional study; neurodegenerative disease; predictive modeling.

In recent years, metabolomics has been used as a powerful tool to better understand the physiol. of neurodegenerative diseases and identify potential biomarkers for progression. We used targeted and untargeted aqueous, and lipidomic profiles of the metabolome from human cerebrospinal fluid to build multivariate predictive models distinguishing patients with Alzheimers disease (AD), Parkinsons disease (PD), and healthy age-matched controls. We emphasize several statistical challenges associated with metabolomic studies where the number of measured metabolites far exceeds sample size. We found strong separation in the metabolome between PD and controls, as well as between PD and AD, with weaker separation between AD and controls. Consistent with existing literature, we found alanine, kynurenine, tryptophan, and serine to be associated with PD classification against controls, while alanine, creatine, and long chain ceramides were associated with AD classification against controls. We conducted a univariate pathway anal. of untargeted and targeted metabolite profiles and find that vitamin E and urea cycle metabolism pathways are associated with PD, while the aspartate/asparagine and c21-steroid hormone biosynthesis pathways are associated with AD. We also found that the amount of metabolite missingness varied by phenotype, highlighting the importance of examining missing data in future metabolomic studies.

Metabolites published new progress about Alzheimer disease. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Yuan published the artcileDesign, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors, Application In Synthesis of 104-01-8, the main research area is aryl thiazolamine preparation acetylcholinesterase inhibitor; Acetylcholinesterase inhibitor; Alzheimer’s disease; Molecular docking.

A series of new 4-arylthiazole-2-amine derivatives I (m = 1,2,3,4; n = 0,1; R1 = pyrrolidin-1-yl, piperidin-1-yl, 1-benzylpiperidin-4-yl, etc.; R2 = H, OMe; R3 = OMe; R4 = H, OMe) as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized, Furthermore, their inhibitory activities against acetylcholinesterase in vitro were tested by Ellman spectrophotometry, and the results of inhibitory activity test showed that most of them had a certain acetylcholinesterase inhibitory activity in vitro. Moreover, the IC50 value of compound I (m = 3; n = 1; R1 = pyrrolidin-1-yl; R2 = H; R3 = OMe; R4 = OMe) was 0.66μM, which was higher than that of Rivastigmine and Huperzine-A as reference compounds, and it had a weak inhibitory effect on butyrylcholinesterase. The potential binding mode of above compound with AChE was investigated by the mol. docking, and the results showed that it was strongly bound up with AChE with the optimal conformation, in addition, their binding energy reached -11.27 Kcal*mol-1. At last, in silico mol. property of the synthesized compounds were predicted by using Molinspiration online servers. It can be concluded that the lead AChEIs above compound presented satisfactory drug-like characteristics.

Bioorganic & Medicinal Chemistry Letters published new progress about Alzheimer disease. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Abdshahzadeh, Helia published the artcile3-aryl coumarin derivatives bearing aminoalkoxy moiety as multi-target-directed ligands against Alzheimer’s disease, COA of Formula: C9H10O3, the main research area is coumarin derivative aminoalkoxy moiety ligand Alzheimer neuroprotectant; 3-phenylcoumarin; Alzheimer’s disease; cholinesterase; neuroprotective activity; synthesis design; β-amyloid.

Two series of novel coumarin derivatives, substituted at 3 and 7 positions with aminoalkoxy groups, are synthesized, characterized, and screened. The effect of amine substituents and the length of cross-linker are investigated in acetyl- and butyrylcholinesterase (AChE and BuChE) inhibition. Target compounds show moderate to potent inhibitory activities against AChE and BuChE. 3-(3,4-Dichlorophenyl)-7-[4-(diethylamino)butoxy]-2H-chromen-2-one (4y) is identified as the most potent compound against AChE (IC50=0.27 μM). Kinetic and mol. modeling studies affirmed that compound 4y works in a mixed-type way and interacts simultaneously with the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. In addition, compound 4y blocks β-amyloid (Aβ) self-aggregation with a ratio of 44.11 % at 100 μM and significantly protects PC12 cells from H2O2-damage in a dose-dependent manner.

Chemistry & Biodiversity published new progress about Alzheimer disease. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem