Day: November 30, 2022

Huang, Yixuan published the artcileInhibition effect of Zedoary turmeric oil on Listeria monocytogenes and Staphylococcus aureus growth and exotoxin proteins production, Computed Properties of 117-96-4, the main research area is Listeria Staphylococcus zedoary turmeric oil exotoxin protein inhibition effect; Listeria monocytogenes; Staphylococcus aureus; Zedoary turmeric oil; essential oil composition; virulence factors.

Purpose. Zedoary turmeric oil (ZTO), the steam extract of Curcuma zedoaria Rosc was researched for its chem. composition, antibacterial activity, and mechanism for countering two major food-borne pathogenic species, Listeria monocytogenes and Staphylococcus aureus. Methodol. Gas chromatog.-mass spectrometry (GC-MS) was used to analyze and characterize the chem. composition of ZTO. Its MICs for the two bacterial species and growth curves were measured. Western blot and real-time reverse-transcription (RT)-PCR assays were utilized to elaborate the mechanism of the antibacterial effect of ZTO by examining the expression levels of virulence-related extracellular proteins. ELISA was used to explore the biol. relevance. Results. GC-MS revealed high contents of curzerene, eucalyptol, germacrone and (-)-g-elemene representing 28.45, 10.94, 10.77 and 10.54%, resp., of the whole components. The MICs of ZTO that combated L. monocytogenes and S. aureus were similar (1-2 mg ml-1 ). After adding ZTO at increasing concentrations, there was an evident reduction in the transcription of hly, iap, hla, sea, seb and agrA in a dose-dependent manner. Furthermore, TNF-α accumulation in RAW264.7 cells stimulated by L. monocytogenes and S. aureus supernatants was restricted by a 1/4 MIC of ZTO. Conclusion. Overall, L. monocytogenes and S. aureus were comparably susceptible to ZTO. These data demonstrated that ZTO’s antimicrobial property was mediated by the repression of the production of virulence factors involved in L. monocytogenes and S. aureus pathogenesis, a finding that can potentially further progress in the development of new anti-virulence drugs.

Journal of Medical Microbiology published new progress about Antibacterial agents. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Computed Properties of 117-96-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dusunceli, Serpil Demir published the artcileSynthesis, antimicrobial properties, and theoretical analysis of benzimidazole-2-ylidene silver(I) complexes, Safety of 4-Methoxyphenylacetic acid, the main research area is crystal mol structure silver benzimidazolylidene complex; silver benzimidazolylidene preparation antimicrobial activity mol docking.

Sym. and nonsym. N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene precursors. These salts were treated with Ag2O to afford their corresponding mononuclear Ag(I)-NHC complexes. These compounds were characterized by spectroscopy techniques and analyzed by DFT/TDDFT and docking methods. Also, the structures of and were determined by single-crystal x-ray crystallog. These new Ag-NHC complexes were screened for their antibacterial activities against Gram-pos., Gram-neg. bacteria, fungi, and nosocomial agents.

Journal of Coordination Chemistry published new progress about Antibacterial agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Nabipour, Hafezeh published the artcileAn environmentally friendly approach to fabricating flame retardant, antibacterial and antifungal cotton fabrics via self-assembly of guanazole-metal complex, Name: 3,5-Diamino-1,2,4-triazole, the main research area is cotton fabric guanazole metal complex flammability antibacterial antifungal property.

Cotton fabrics are prone to ignite fire accidents as well as breed bacteria and fungi, which have hampered their applications in the field of packaging and home decorations. Guanazole complexes with silver and zinc ions were deposited to cotton fabrics through self-assembly to prepare the flame-retardant and antibacterial cotton fabrics. The effect of the guanazole-metal complexes on the morphol. structure, flammability and thermal degradation of cotton fabrics was studied by field emission SEM, limiting oxygen index (LOI), UL-94 vertical burning test, and thermogravimetric anal. The antibacterial and antifungal activities of the coated fabrics were evaluated as well. The guanazole-zinc and guanazole-silver treated cotton fabrics showed a high LOI of 29.5% and 27.5%, resp. In the vertical burning test, both the guanazole-zinc and guanazole-silver treated cotton fabrics self-extinguished when removing the ignition source, displaying a UL-94 V-0 classification, while the untreated one and the guanazole-treated one burned out. Thermogravimetric anal. results confirmed that the guanazole-metal complexes promoted the thermal decomposition of cotton and thus improved the char yield significantly. Micro-scale combustion calorimeter measurements clarified that the guanazole-zinc and guanazole-silver treated cotton displayed dramatically decreased peak heat release rate (64.4% and 59.1%, resp.) and total heat release (26.4% and 14.8%, resp.) in comparison to the untreated one. The significantly improved flame retardancy of guanazole-metal complexes treated cotton fabrics could be attributed to their enhanced charring capability that blocked flammable volatiles into flame zone. The treated cotton fabrics with guanazole-metal complexes exhibited better antibacterial capacity against Staphylococcus aureus and Escherichia coli than the untreated and guanazole-treated ones. Furthermore, the guanazole-silver treated cotton fabrics also showed good antifungal activity against Penicillium, Fusarium chlamydosporum and Aspergillus niger.

Journal of Cleaner Production published new progress about Antibacterial agents. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Name: 3,5-Diamino-1,2,4-triazole.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Nabipour, Hafezeh published the artcileAn environmentally friendly approach to fabricating flame retardant, antibacterial and antifungal cotton fabrics via self-assembly of guanazole-metal complex, Product Details of C2H5N5, the main research area is cotton fabric guanazole metal complex flammability antibacterial antifungal property.

Cotton fabrics are prone to ignite fire accidents as well as breed bacteria and fungi, which have hampered their applications in the field of packaging and home decorations. Guanazole complexes with silver and zinc ions were deposited to cotton fabrics through self-assembly to prepare the flame-retardant and antibacterial cotton fabrics. The effect of the guanazole-metal complexes on the morphol. structure, flammability and thermal degradation of cotton fabrics was studied by field emission SEM, limiting oxygen index (LOI), UL-94 vertical burning test, and thermogravimetric anal. The antibacterial and antifungal activities of the coated fabrics were evaluated as well. The guanazole-zinc and guanazole-silver treated cotton fabrics showed a high LOI of 29.5% and 27.5%, resp. In the vertical burning test, both the guanazole-zinc and guanazole-silver treated cotton fabrics self-extinguished when removing the ignition source, displaying a UL-94 V-0 classification, while the untreated one and the guanazole-treated one burned out. Thermogravimetric anal. results confirmed that the guanazole-metal complexes promoted the thermal decomposition of cotton and thus improved the char yield significantly. Micro-scale combustion calorimeter measurements clarified that the guanazole-zinc and guanazole-silver treated cotton displayed dramatically decreased peak heat release rate (64.4% and 59.1%, resp.) and total heat release (26.4% and 14.8%, resp.) in comparison to the untreated one. The significantly improved flame retardancy of guanazole-metal complexes treated cotton fabrics could be attributed to their enhanced charring capability that blocked flammable volatiles into flame zone. The treated cotton fabrics with guanazole-metal complexes exhibited better antibacterial capacity against Staphylococcus aureus and Escherichia coli than the untreated and guanazole-treated ones. Furthermore, the guanazole-silver treated cotton fabrics also showed good antifungal activity against Penicillium, Fusarium chlamydosporum and Aspergillus niger.

Journal of Cleaner Production published new progress about Antibacterial agents. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Product Details of C2H5N5.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Nabipour, Hafezeh published the artcileA phosphaphenanthrene-containing vanillin derivative as co-curing agent for flame-retardant and antibacterial epoxy thermoset, Computed Properties of 1455-77-2, the main research area is vanillin derivative curing flame retardant antibacterial epoxy thermoset preparation.

A phosphaphenanthrene-containing vanillin-derived compound (VDG) was synthesized by a one-pot nucleophilic addition reaction from vanillin, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), and 3,5-diamino-1,2,4-triazole. The mol. structure of VDG was characterized by Fourier transform IR, and 1H, 13C, and 31P NMR spectrometer. Various loadings of VDG were incorporated into diglycidyl ether of bisphenol A (DGEBA) as a co-curing agent together with 4, 4′-diaminodiphenylmethane to produce an epoxy thermoset. The thermomech., thermal and fire-retardant properties of EP thermosets were evaluated by dynamic mech. analyzer, differential scanning calorimetry, thermogravimetric anal., limiting oxygen index (LOI), UL-94, and cone calorimetry. The results showed that a linear decrease in glass transition temperature with increasing loading of VDG owing to the declined crosslinking d. The cured DGEBA/DDM system with 2.0 wt% of VDG exhibited super anti-flammability in terms of a high LOI value of 37.0% and UL-94 V-0 rating, whereas the cured DGEBA/DDM and DGEBA/DDM with 2.0 wt% of DOPO systems showed no rating in UL-94 test. In addition, cone calorimetry test showed that the cured DGEBA/DDM system with 2.0 wt% of VDG exhibited a reduction of up to 47.5% and 34% for peak heat release rate and total heat release, resp., compared to the cured DGEBA/DDM system. The enhanced flame-retardant property was attributed to the formation of the compact and continual structure of char layer residue with good thermo-oxidative stability. In addition to good anti-flammability, the cured DGEBA/DDM/VDG thermoset showed antibacterial property against E. coli, with an inhibition zone diameter of 10 mm. Thus, this bio-based co-curing agent could impart flame-retardant and antibacterial performance to epoxy for developing high performance functional thermosetting materials.

Polymer published new progress about Antibacterial agents. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Computed Properties of 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pund, Amit A. published the artcileSynthesis of 2,5-disubstituted-1,3,4-thiadiazole derivatives from (2S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl) amino] propanoic acid and evaluation of anti-microbial activity, Product Details of C9H10O3, the main research area is disubstituted thiadiazole preparation antibacterial antifungal.

The new compounds 2,5-disubstituted-1,3,4-thiadiazole derivatives I [R = 3-OH, 2-F, 3-OMe, etc.] were synthesized from starting material (2S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]propanoic acid. The intermediate 2,5-disubstituted-1,3,4-thiadiazole amine was prepared by coupling of (2S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl) amino]propanoic acid with pyridine-2-carboxylic acid hydrazide in the presence of carbonyldiimidazole (CDI) followed by 1,3,4-thiadiazole ring formation via diacylhydrazines derivative and deprotection with shorter reaction time and excellent yield. The structures of new compounds were confirmed by spectral anal. The series of new synthesized compounds were evaluated for their anti-microbial activities in vitro and compounds I [R = 4-NO2, 3-NO2, 3-(OMe)2, 2-F] showed strong activities against all tested microorganisms.

Synthetic Communications published new progress about Antibacterial agents. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vaarla, Krishnaiah published the artcileSolvent-Free One-Pot Tandem Multicomponent Synthesis of Triazolothiadiazinyl Coumarins and Their Antimicrobial Properties, SDS of cas: 104-01-8, the main research area is triazolothiadiazinylcoumarin preparation antibacterial antifungal SAR solvent free; carboxylic acid thiocarbohydrazide bromoacetylcoumarin tandem one pot multicomponent reaction.

In this report the synthesis, characterization and antimicrobial activity evaluation of a series of triazolo-thiadiazinyl coumarin derivatives I (R = Me, Et, CF3; R1 = H, OMe, OEt, etc.; R2 = H, Cl, Br) and II (R3 = H, Cl, Br; R4 = H, Cl, Br, etc.; R5 = 4-MeOC6H4, isoindoline-1,3-dione). The triazolo thiadiazinyl coumarins were synthesized in a facile tandem solvent free one-pot multi component reaction approach by taking various aliphatic/ aromatic/ heterocyclic carboxylic acids, thiocarbohydrazide and substituted 3-(2-bromoacetyl)coumarins. The newly synthesized mols. were confirmed on the basis of phys., anal. and single crystal X-ray diffraction data. The triazolo thiadiazinyl coumarins exhibited excellent antimicrobial activity against Gram pos., Gram neg. and fungi microbial strains. Among the tested compounds, compounds I (R = Et, R1 = H, R2 = Br), I (R = Et, R1 = R2 = Br), II (R1 = R2 = Cl; R3 = isoindoline-1,3-dione), II (R1 = H; R2 = Br; R3 = isoindoline-1,3-dione) and II (R1 = R2 = Br; R3 = isoindoline-1,3-dione) exhibited potent antimicrobial activity at 25μg/mL concentration against Gram pos. and Gram neg. bacterial strains.

ChemistrySelect published new progress about Antibacterial agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Asha Bhanu, P. published the artcileFacile synthesis and docking studies of 7-hydroxyflavanone isoxazoles and acrylates as potential anti-microbial agents, Related Products of isoquinoline, the main research area is isoxazolyl chromanone preparation antibacterial antifungal mol docking; oxochromanyl cinnamate preparation antibacterial antifungal mol docking.

Two series of compounds, 2-phenyl-7-((3-phenylisoxazol-5-yl)methoxy)chroman-4-ones I [R1 = Ph, 4-MeC6H4, 2,3-(MeO)C6H3, 3,4,5-(MeO)3C6H2, etc.] and 4-oxo-2-phenylchroman-7-yl acrylates II (R2 = Ph, 4-FC6H4, 2-Cl-6-FC6H3, 3-O2NC6H4. etc.), were synthesized starting from 7-hydroxyflavanone. All the compounds were subjected to antibacterial, antifungal activity and mol. docking studies. The results showed that majority of the compounds exhibited potent antibacterial and antifungal activities when compared with the standard drugs. Further, the docking studies revealed that the compounds I (R1 = Ph) and II (R2 = 4-BrC6H4) have the highest binding affinity score of sterol 14-α demethylase and DNA gyrase B, resp.

Medicinal Chemistry Research published new progress about Antibacterial agents. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dabholkar, Vijay V. published the artcileOne pot synthesis and biological evaluation of novel fused thiadiazolo-pyrimidine derivatives, SDS of cas: 104-01-8, the main research area is thiadiazolopyrimidine preparation antifungal antibacterial activity; malononitrile aryl aldehyde amino benzyl thiadiazole heterocyclization.

One pot synthesis of thiadiazolopyrimidinecarbonitriles I (R = 2-MeC6H4, 4-MeOC6H4, 4-ClC6H4, 2,4-Cl2C6H3, Ph; R1 = H, Cl, OMe) was achieved by the reaction of 5-(arylmethyl)-1,3,4-thiadiazole-2-amines, aromatic aldehydes 4-R1C6H4CHO (R1 = H, Cl, OMe), and malononitrile. The contents were refluxed in presence of triethylamine as a catalyst and ethanol as a solvent. Selected I were screened for antimicrobial activity against the Gram-neg. bacteria E. coli and P. aeruginosa and the Gram-pos. bacteria S. aureus, and C. diphtheriae.

Heterocyclic Letters published new progress about Antibacterial agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem