Asha Bhanu, P. published the artcileFacile synthesis and docking studies of 7-hydroxyflavanone isoxazoles and acrylates as potential anti-microbial agents, Related Products of isoquinoline, the main research area is isoxazolyl chromanone preparation antibacterial antifungal mol docking; oxochromanyl cinnamate preparation antibacterial antifungal mol docking.
Two series of compounds, 2-phenyl-7-((3-phenylisoxazol-5-yl)methoxy)chroman-4-ones I [R1 = Ph, 4-MeC6H4, 2,3-(MeO)C6H3, 3,4,5-(MeO)3C6H2, etc.] and 4-oxo-2-phenylchroman-7-yl acrylates II (R2 = Ph, 4-FC6H4, 2-Cl-6-FC6H3, 3-O2NC6H4. etc.), were synthesized starting from 7-hydroxyflavanone. All the compounds were subjected to antibacterial, antifungal activity and mol. docking studies. The results showed that majority of the compounds exhibited potent antibacterial and antifungal activities when compared with the standard drugs. Further, the docking studies revealed that the compounds I (R1 = Ph) and II (R2 = 4-BrC6H4) have the highest binding affinity score of sterol 14-α demethylase and DNA gyrase B, resp.
Medicinal Chemistry Research published new progress about Antibacterial agents. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem