Abdshahzadeh, Helia published the artcile3-aryl coumarin derivatives bearing aminoalkoxy moiety as multi-target-directed ligands against Alzheimer’s disease, COA of Formula: C9H10O3, the main research area is coumarin derivative aminoalkoxy moiety ligand Alzheimer neuroprotectant; 3-phenylcoumarin; Alzheimer’s disease; cholinesterase; neuroprotective activity; synthesis design; β-amyloid.
Two series of novel coumarin derivatives, substituted at 3 and 7 positions with aminoalkoxy groups, are synthesized, characterized, and screened. The effect of amine substituents and the length of cross-linker are investigated in acetyl- and butyrylcholinesterase (AChE and BuChE) inhibition. Target compounds show moderate to potent inhibitory activities against AChE and BuChE. 3-(3,4-Dichlorophenyl)-7-[4-(diethylamino)butoxy]-2H-chromen-2-one (4y) is identified as the most potent compound against AChE (IC50=0.27 μM). Kinetic and mol. modeling studies affirmed that compound 4y works in a mixed-type way and interacts simultaneously with the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. In addition, compound 4y blocks β-amyloid (Aβ) self-aggregation with a ratio of 44.11 % at 100 μM and significantly protects PC12 cells from H2O2-damage in a dose-dependent manner.
Chemistry & Biodiversity published new progress about Alzheimer disease. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem