Zhang, Huan published the artcileExperimental and Computational Studies of the Iron-Catalyzed Selective and Controllable Defluorosilylation of Unactivated Aliphatic gem-Difluoroalkenes, Quality Control of 1205-17-0, the main research area is fluoroalkene defluorosilylation iron catalysis silylalkene preparation stereoselective DFT; optimized mol structure fluoroalkene defluorosilylation iron catalyst silylalkene preparation; C−F bond cleavage; gem-disilylated alkenes; high selectivity; iron catalysis.
The 1st Fe-catalyzed defluorosilylation of unactivated gem-difluoroalkenes was developed, delivering gem-disilylated alkenes and (E)-silylated alkenes with excellent efficiency. This protocol features good functional group compatibility and excellent regio- and stereoselectivity, enabling the late-stage silylation of biol. relevant compounds, thus providing good opportunities for applications in medicinal chem. Preliminary mechanistic studies and DFT calculations reveal that a nucleophilic addition and elimination of the 2nd C-F bond might be involved in the disilylation catalytic system, demonstrating unusual reactivity characteristics of Fe catalysis.
Angewandte Chemie, International Edition published new progress about C-F bond cleavage. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Quality Control of 1205-17-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem