Category: 1041423-28-2

1041423-28-2, Name is 3-Chloro-6-fluoroisoquinoline, belongs to isoquinoline compound, is a common compound. COA of Formula: C9H5ClFNIn an article, once mentioned the new application about 1041423-28-2.

Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including Alzheimer’s disease. In vivo detection of NFTs using PET imaging represents a unique opportunity to develop a pharmacodynamic tool to accelerate the discovery of new disease modifying therapeutics targeting tau pathology. Herein, we present the discovery of 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine, 6 ([18F]-MK-6240), as a novel PET tracer for detecting NFTs. 6 exhibits high specificity and selectivity for binding to NFTs, with suitable physicochemical properties and in vivo pharmacokinetics.

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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Electric Literature of 1041423-28-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 1041423-28-2, 3-Chloro-6-fluoroisoquinoline, introducing its new discovery.

The invention relates to 6-substituted isoquinoline derivatives of the Formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 1041423-28-2. In my other articles, you can also check out more blogs about 1041423-28-2

Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H2171N – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. SDS of cas: 1041423-28-2. Introducing a new discovery about 1041423-28-2, Name is 3-Chloro-6-fluoroisoquinoline

PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES

Pyrrolopyridine compounds of formula (I) or their pharmaceutically acceptable salts are disclosed, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha- synuclein aggregates, and hence are useful in binding and imaging tau aggregates in Alzheimer’s patients. More specifically, the compounds are used as tracers in positron emission tomography (PET) imaging to study tau deposits in brain in vivo to allow diagnosis of Alzheimer’s disease and other neurodegenerative diseases characterized by tau pathology. Futher, the compounds are useful for measuring clinical efficacy of therapeutic agents for Alzheimer’s disease and other neurodegenerative diseases characterized by tau pathology.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 1041423-28-2, you can also check out more blogs about1041423-28-2

Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

1041423-28-2, 3-Chloro-6-fluoroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 4: 16.5 g of (cis-4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester were dissolved in 210 ml of diglyme and treated with 4.1g 50% NaH under nitrogen. The resulting mixture was stirred for 1 h at room temperature, then 14.8 g of the product from Step 3 were added. The mixture was allowed to stir for 1 day at room temperature, then 100 ml of toluene were added and the resulting mixture was washed with water 3 times. The organic phases were collected and the solvent was removed in vacuo., 1041423-28-2

As the paragraph descriping shows that 1041423-28-2 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS; WO2008/77554; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1041423-28-2,3-Chloro-6-fluoroisoquinoline,as a common compound, the synthetic route is as follows.

Step 4:16.5 g of N-Boc-4-hydroxypiperidine were dissolved in 210ml of diglyme and treated with 4.1g 50% NaH under nitrogen. The resulting mixture was stirred for 1h at room temperature, then 14.8 g of the product from Step 4 was added. The mixture was allowed to stir for 1 day at room temperature, then 100 ml of toluene were added and the resulting mixture was washed with water 3 times. The organic phases were collected and the solvent was removed in vacuo., 1041423-28-2

The synthetic route of 1041423-28-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; WO2007/240; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem