Category: 106778-43-2

Some tips on 106778-43-2

106778-43-2, The synthetic route of 106778-43-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.

[00191] Isoquinoline-6-carbohydrazide: Isoquinoline-6-carboxylic acid (1.2 g,6.94 mmol) purchased from Gateway Chemical Technology, Inc. was mixed with CDI (1.68 g, 10.4 mmol) in DMF (20 Ml) in a round bottom flask. After the mixture was stirred for 30 minutes at 2O0C, anhydrous hydrazine (2 mL) was added and the resulting mixture was stirred at 2O0C for one hour. After removing the solvent at a reduced pressure, the remaining residue was mixed with 20 mL water. After filtration, washing with water and air drying, an off-white solid was obtained as the desired product. LCMS (API-ES) m/z (%): 188.0 (100%, M++H).

106778-43-2, The synthetic route of 106778-43-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2009/11880; (2009); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

New learning discoveries about 106778-43-2

106778-43-2, As the paragraph descriping shows that 106778-43-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.

Benzyl-N-(2-amino-2-phenyl-ethyl)carbamate (2.00 g, 7.40 mmol)Soluble in DMF (10.0mL),Add benzotriazole-N,N,N’,N’-tetramethylurea hexafluorophosphate (2.07 g, 8.14 mmol),Isoquinoline-6-carboxylic acid (1.28 g, 7.40 mmol)And N,N-diisopropylethylamine (3.38 g, 29.6 mmol),After stirring for 1 hour, it was extracted with ethyl acetate and water.The solvent was distilled off under reduced pressure.Purification by column chromatography gave benzyl-N-((S)-2-(isoquinolin-6-carboxamide)-2-phenyl-ethyl)carbamate (1.98 g, 4.21 mmol, yield 57 %).

106778-43-2, As the paragraph descriping shows that 106778-43-2 is playing an increasingly important role.

Reference£º
Patent; Chengdu Xiandao Pharmaceutical Development Co., Ltd.; Li Jin; Zhang Dengyou; Feng Jingchao; Liao Wei; Lin Li; Li Si; Chen Wei; (12 pag.)CN109134433; (2019); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

Some tips on 106778-43-2

The synthetic route of 106778-43-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.

90.0 mg of (1S)-N’,N’-dimethyl-1-phenyl-ethane-1,2-diamine (550 mumol) was dissolved in 10.0 mL of DMF, to which 153 mg of HBTU (600 mumol), 105 mg of 6-isoquinolinecarboxylic acid (600 mumol) and 284 g of N, N-diisopropyl ethylamine (2.19 mmol) were added. The reaction mixture was stirred for 1 h and extracted with ethyl acetate and water. Then the aqueous phase was extracted twice with ethyl acetate, and the organic phases were combined, dried with anhydrous sodium sulfate, desolventized under vacuum and purified by column chromatography to give 52 mg of benzyl-N-((2S)-2-(isoquinoline-6-formamide)-2-phenyl-ethyl) carbamate (0.13 mmol) with a yield of 24%., 106778-43-2

The synthetic route of 106778-43-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hitgen Ltd.; LI, Jin; ZHANG, Dengyou; FENG, Jingchao; LIAO, Wei; LIN, Li; LI, Si; CHEN, Wei; (41 pag.)EP3640242; (2020); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem