With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.
Benzyl-N-(2-amino-2-phenyl-ethyl)carbamate (2.00 g, 7.40 mmol)Soluble in DMF (10.0mL),Add benzotriazole-N,N,N’,N’-tetramethylurea hexafluorophosphate (2.07 g, 8.14 mmol),Isoquinoline-6-carboxylic acid (1.28 g, 7.40 mmol)And N,N-diisopropylethylamine (3.38 g, 29.6 mmol),After stirring for 1 hour, it was extracted with ethyl acetate and water.The solvent was distilled off under reduced pressure.Purification by column chromatography gave benzyl-N-((S)-2-(isoquinolin-6-carboxamide)-2-phenyl-ethyl)carbamate (1.98 g, 4.21 mmol, yield 57 %).
106778-43-2, As the paragraph descriping shows that 106778-43-2 is playing an increasingly important role.
Reference£º
Patent; Chengdu Xiandao Pharmaceutical Development Co., Ltd.; Li Jin; Zhang Dengyou; Feng Jingchao; Liao Wei; Lin Li; Li Si; Chen Wei; (12 pag.)CN109134433; (2019); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem