Category: 1075-11-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1075-11-2,6-Fluoroisoquinoline,as a common compound, the synthetic route is as follows.

Example 13 1-chloro-6-fluoro-isoquinoline; To a solution of 6-fluoroisoquinoline (2.64 g, 17.9 mmol) in CH2Cl2 (70 mL) cooled at 0 C., MCPBA is added (3.4 g, 19.69 mmol). The reaction mixture is stirred at RT for 16 h. After 1 h of stirring, a yellow white precipitate forms. The solvent is evaporated under reduced pressure. To the yellow solid is added CH2Cl2 (5 mL), and the solid is isolated by vacuum filtration. Rinsing the solid with CH2Cl2 yields a white solid, which is dried under vacuum to afford 3 g (100%) of 6-fluoro-isoquinoline N-oxide.

1075-11-2 6-Fluoroisoquinoline 21889847, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; Huang, Kenneth He; Veal, James; Barta, Thomas; Smith, Emilie D.; Ma, Wei; Ommen, Andy; US2008/70935; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1075-11-2, 6-Fluoroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In general, the 6-fluoro and 6-alkyl isoquinolines used in the following experiments were prepared via a Pomeranz-Fritsch synthesis (Typical procedure: Preparation of optically active 8,8-disubstituted 1, 1-biisoquinoline, K.Hirao, R. Tsuchiya, Y. Yano, H. Tsue, Heterocycles 42(1) 1996,415-422) as outlined below. The products were converted into the 1-chloro derivatives via N-oxide intermediates as described elsewhere. General Synthetic Scheme EMI271.1Reagents and reaction conditions: (a) reflux in benzene, azeotropic removal of water; (b) first step: ethyl chloroformate, trimethyl phosphite in THF, second step: titanium tetrachloride in chloroform; (c) MCPBA inCH2CI2 ; (d) POCl3 in benzene

The synthetic route of 1075-11-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99274; (2003); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1075-11-2, 6-Fluoroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Dimethylsulfamoyl chloride (34; 0.144 mL, 1.34 mmol) was added to a solution of isoquinoline (5; 157 mg, 1.22 mmol) and 1H-indol-7-yl acetate (33; 213 mg, 1.22 mmol) in toluene (4 mL) at r.t. The mixture was concentrated to a thick but stirrable paste (1.5 mL), which was stirred at 50 C for 3 h. TLC and LCMS showed reaction was largely complete by this time. The mixture was diluted with EtOAc (40 mL), washed with H2O (40 mL) and sat. brine (20 mL), dried (Na2SO4), filtered and evaporated to dryness. The residue was purified by flash silica gel chromatography (loading in CH2Cl2) (eluent: gradient 20 to 50% EtOAc in heptane). Fractions containing the desired product were evaporated to afford the title compound 37a (208 mg, 42%) as a white solid

As the paragraph descriping shows that 1075-11-2 is playing an increasingly important role.

Reference£º
Article; Pearson, Stuart E.; Fillery, Shaun M.; Goldberg, Kristin; Demeritt, Julie E.; Eden, Jonathan; Finlayson, Jonathan; Patel, Anil; Synthesis; vol. 50; 24; (2018); p. 4963 – 4981;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem