Category: 1205-17-0

Jiang, Hui-Min published the artcileCopper-promoted cross-coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines using a peroxide-driven radical reductive strategy, COA of Formula: C11H12O3, the main research area is alkyl benzenamine preparation chemoselective; nitroarene alkyl dihydropyridine cross coupling reaction copper catalyst.

A copper-promoted reductive cross-coupling of nitroarenes RNO2 (R = Ph, 4-iodiphenyl, pyridin-3-yl, etc.) with 4-alkyl-1,4-dihydropyridines I (R1 = Pr, cyclohexyl, Bn, etc.) for producing N-alkylbenzenamines RNHR1 is described. Using 4-alkyl-1,4-dihydropyridines I as alkyl radical sources and internal reducing agents enables the construction of C(sp3)-N bonds under oxidative conditions, which provide an elegant complementary platform to assemble N-alkylbenzenamines with good tolerance for sensitive functional groups.

Organic Chemistry Frontiers published new progress about Anilines Role: SPN (Synthetic Preparation), PREP (Preparation) (alkyl). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, COA of Formula: C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Martin, Ruben published the artcileAn Improved Protocol for the Pd-Catalyzed α-Arylation of Aldehydes with Aryl Halides, Synthetic Route of 1205-17-0, the main research area is aldehyde aryl bromide palladium catalyst alpha arylation; aryl chloride aldehyde palladium catalyst alpha arylation; alpha aryl aldehyde preparation; sporochnol preparation.

An improved protocol for the Pd-catalyzed α-arylation of aldehydes with aryl halides has been developed. The new catalytic system allows for the coupling of an array of substrates including challenging electron-rich aryl bromides and less reactive aryl chlorides. The utility of this method has been demonstrated in a new total synthesis of (±)-sporochnol.

Organic Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (α-aryl). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Duan, Ya-Nan published the artcileHomogeneous hydrogenation with a cobalt/tetraphosphine catalyst: a superior hydride donor for polar double bonds and N-heteroarenes, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is alc amine preparation chemoselective; aldehyde ketone imine heteroarene hydrogenation cobalt tetraphosphine catalyst.

The development of catalysts based on earth abundant metals in place of noble metals is becoming a central topic of catalysis. Herein, a cobalt/tetraphosphine complex catalyzed homogeneous hydrogenation of polar unsaturated compounds using an air- and moisture-stable and scalable precatalyst is reported. By activation with potassium hydroxide, this cobalt system shows both high efficiency (up to 24000 TON and 12000 h-1 TOF) and excellent chemoselectivities with various aldehydes, ketones, imines and even N-heteroarenes. The preference for 1,2-reduction over 1,4-reduction makes this method an efficient way to prepare allylic alcs. and amines. Meanwhile, efficient hydrogenation of the challenging N-heteroarenes is also furnished with excellent functional group tolerance. Mechanistic studies and control experiments demonstrated that a CoIH complex functions as strong hydride donor in the catalytic cycle. Each cobalt intermediate on the catalytic cycle was characterized and a plausible outer-sphere mechanism was proposed. Noteworthy, external inorganic base plays multiple roles in this reaction and functions in almost every step of the catalytic cycle.

Journal of the American Chemical Society published new progress about Alcohols, unsaturated Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Menon, A. Nirmala published the artcileFree and glycosidically bound volatiles of cardamom (Eletteria cardamomum Maton var. miniscula Burkill), Synthetic Route of 1205-17-0, the main research area is cardamom aroma volatiles; terpene cardamom aroma.

The bound aroma compounds from fresh green cardamom (Eletteria cardamomum Maton) were isolated by adsorption on Amberlite XAD-2. The free volatiles were eluted with ether: pentane (1:1) and the bound compounds with methanol. After hydrolysis of the latter fraction with β-glucosidase, the aglycons were identified by GC and GC-MS. The major compounds in this fraction were 3-methylpentan-2-ol, linalool and the cis- and trans-isomers of nerolidol and farnesol.

Flavour and Fragrance Journal published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Braun, Thomas published the artcileEnterochromaffin cells of the human gut: sensors for spices and odorants, Formula: C11H12O3, the main research area is enterochromaffin cell gut calcium olfactory receptor.

Background & Aims: Release of serotonin from mucosal enterochromaffin cells triggered by luminal substances is the key event in the regulation of gut motility and secretion. We were interested to know whether nasal olfactory receptors are also expressed in the human gut mucosa by enterochromaffin cells and whether their ligands and odorants present in spices, fragrances, detergents, and cosmetics cause serotonin release. Methods: Receptor expression was studied by the reverse-transcription polymerase chain reaction method in human mucosal enterochromaffin cells isolated by laser microdissection and in a cell line derived from human enterochromaffin cells. Activation of the cells by odorants was investigated by digital fluorescence imaging using the fluorescent Ca2+ indicator Fluo-4. Serotonin release was measured in culture supernatants by a serotonin enzyme immunoassay and amperometry using carbon fiber microelectrodes placed on single cells. Results: We found expression of 4 olfactory receptors in micro-dissected human mucosal enterochromaffin cells and in a cell line derived from human enterochromaffin cells. Ca2+ imaging studies revealed that odorant ligands of the identified olfactory receptors cause Ca2+ influx, elevation of intracellular free Ca2+ levels, and, consequently, serotonin release. Conclusions: Our results show that odorants present in the luminal environment of the gut may stimulate serotonin release via olfactory receptors present in human enterochromaffin cells. Serotonin controls both gut motility and secretion and is implicated in pathol. conditions such as vomiting, diarrhea, and irritable bowel syndrome. Thus, olfactory receptors are potential novel targets for the treatment of gastrointestinal diseases and motility disorders.

Gastroenterology published new progress about Aldehydes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Murugesan, Kathiravan published the artcileHomogeneous cobalt-catalyzed reductive amination for synthesis of functionalized primary amines, Application In Synthesis of 1205-17-0, the main research area is carbonyl compound ammonia cobalt catalyst reductive amination; primary amine preparation.

The combination of cobalt and linear-triphos (bis(2-diphenylphosphinoethyl)phenylphosphine) as the molecularly-defined non-noble metal catalyst for the synthesis of linear and branched benzylic, heterocyclic and aliphatic primary amines from carbonyl compounds, gaseous ammonia and hydrogen in good to excellent yields was reported. Noteworthy, this cobalt catalyst exhibited high selectivity and as a result the -NH2 moiety was introduced in functionalized and structurally diverse mols. An inner-sphere mechanism on the basis of the mono-cationic [triphos-CoH]+ complex as active catalyst was proposed and supported with d. functional theory computation on the doublet state potential free energy surface and H2 metathesis was found as the rate-determining step.

Nature Communications published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Murugesan, Kathiravan published the artcileReusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is primary amine preparation nickel nanoparticle catalyst; carbonyl compound ammonia mol hydrogen reductive amination; ammonia; carbonyl compounds; nickel nanoparticles; primary amines; reductive amination.

The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of mol. hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.

Angewandte Chemie, International Edition published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Larsson, Linda published the artcileUltra-high olfactory sensitivity for the human sperm-attractant aromatic aldehyde bourgeonal in CD-1 mice, Quality Control of 1205-17-0, the main research area is sperm chemoattractant bourgeonal behavior olfactory sensitivity aromatic aldehyde.

Recent studies have shown that certain aromatic aldehydes are ligands for olfactory receptors expressed in mammalian sperm cells and induce sperm chemotaxis. Using a conditioning paradigm, the olfactory sensitivity of five CD-1 mice for seven aromatic aldehydes was investigated. With all seven stimuli, the mice discriminated concentrations as low as 0.01 ppm (ppm) from the solvent, and with bourgeonal the animals even detected concentrations as low as 0.1 ppq (parts per quadrillion) which constitutes the lowest olfactory detection threshold value reported in this species so far. The presence of a tert-Bu group in para-position (relative to the functional aldehyde group) combined with a lack of an addnl. alkyl group next to the functional aldehyde group may be responsible for the extraordinary sensitivity of the mice for bourgeonal.

Neuroscience Research (Shannon, Ireland) published new progress about Aryl aldehydes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Quality Control of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bartoli, Mattia published the artcileAn easily recoverable and recyclable homogeneous polyester-based Pd catalytic system for the hydrogenation of α,β-unsaturated carbonyl compounds, Application In Synthesis of 1205-17-0, the main research area is polyester palladium complex unsaturated carbonyl hydrogenation homogeneous catalyst.

Homogeneous catalysis is an efficient tool to carry out hydrogenation processes but the major drawback is represented by the separation of the expensive catalyst from the product mixture In this view we prepared a polyester-based Pd catalytic system that offers the advantages of both homogenous and heterogeneous catalyzes: efficacy, selectivity and recyclability. Here its application in the hydrogenation of selected α,β-unsaturated carbonyl compounds is described.

Catalysis Communications published new progress about Carbonyl compounds (organic) Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Arya, Gunjan H. published the artcileThe genetic basis for variation in olfactory behavior in Drosophila melanogaster, Application In Synthesis of 1205-17-0, the main research area is Obp83g Or7a lr40a Gr57a polymorphism olfactory behavior Drosophila; Drosophila melanogaster Genetic Reference Panel; behavioral genetics; genetic networks; genome-wide association analysis; olfactory behavior.

The genetic underpinnings that contribute to variation in olfactory perception are not fully understood. To explore the genetic basis of variation in olfactory perception, we measured behavioral responses to 14 chem. diverse naturally occurring odorants in 260400 flies from 186 lines of the Drosophila melanogaster Genetic Reference Panel, a population of inbred wild-derived lines with sequenced genomes. We observed variation in olfactory behavior for all odorants. Low to moderate broad-sense heritabilities and the large number of tests for genotype-olfactory phenotype association performed precluded any individual variant from reaching formal significance. However, the top variants (nominal P < 5 × 10-5) were highly enriched for genes involved in nervous system development and function, as expected for a behavioral trait. Further, pathway enrichment analyses showed that genes tagged by the top variants included components of networks centered on cyclic guanosine monophosphate and inositol triphosphate signaling, growth factor signaling, Rho signaling, axon guidance, and regulation of neural connectivity. Functional validation with RNAi and mutations showed that 15 out of 17 genes tested indeed affect olfactory behavior. Our results show that in addition to chemoreceptors, variation in olfactory perception depends on polymorphisms that can result in subtle variations in synaptic connectivity within the nervous system. Chemical Senses published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem