Category: 1205-17-0

Scrivanti, Alberto published the artcileArylation of β-methallyl alcohol catalyzed by Pd(OAc)2 in combination with P(t-Bu)3: application to fragrance synthesis, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is arylmethylpropana helional canthoxal lilial preparation fragrance; methallyl alc arylation aryl bromide catalyst palladium phosphine.

Pd(OAc)2 in combination with P(t-Bu)3 catalyzes the coupling of β-methallyl alc. with 1-bromo-3,4-(methylenedioxy)benzene (I), 1-bromo-4-methoxybenzene (II), or 1-bromo-4-tert-butylbenzene (III). The reaction affords the corresponding 2-methyl-3-aryl-propanals, which are valuable floral fragrances. With I or II high reaction rates are obtained at 130 °C using NMP/water mixtures and an inorganic base such as Na2CO3. The chemoselectivity of the reaction is almost complete, so that the process appears practically feasible. In contrast, the coupling of β-methallyl alc. with III proceeds with low reaction rates.

Tetrahedron published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Din, Zia Ud published the artcileSymmetrical and unsymmetrical substituted 2,5-diarylidene cyclohexanones as anti-parasitic compounds, Synthetic Route of 1205-17-0, the main research area is diarylidene cyclohexanone sym unsym preparation antiparasitic mol docking; 2,5-diarylidene cyclohexanones; Anti-parasitic; DFT analysis; Docking; T cruzi.

Sym. and unsym. bis-aryl-α,β-unsaturated ketones I (R = Ph, 4-MeOC6H4, 2-ClC6H4, etc.) and II [R1 = R2 = H, R3 = OMe, R4 = Ph, 4-MeNC6H4, 2,3-(MeO)2C6H3, 4-O2NC6H4, etc.; R1 = R2 = OMe, R3 = H, R4 = Ph, 4-BrC6H4, 2,6-Cl2C6H3, 2-MeO-4-O2NC6H3, etc.] were synthesized in moderate to excellent yield by treating cyclohexanone with various aldehydes. Dimethylammonium dimethylcarbamate (DIMCARB) was used as both catalyst and reaction medium for the synthesis of monoarylidenes cycloadduct intermediates, which were further used to produce diarylidene cyclohexanones. All 34 compounds synthesized were evaluated for their anti-proliferative activity, particularly against promastigote of Leishmania amazonensis, epimastigote and trypomastigote of Trypanosoma cruzi. Eighteen compounds displayed anti-leishmanial activity against promastigotes of L. amazonensis with IC50 values ranging from 2.8 to 10 μM. In addition, two compounds exhibited significant antitrypanosomal activity against epimastigotes of T. cruzi with IC50 values of 5.2±0.8 and 3.0±0.0μM, while five compounds exhibited activity from 15.0±1.4 to 30.2±1.8μM against trypomastigote of T. cruzi. Moreover, all compounds were more selective against the parasites than the epithelial cells. The unsym. compounds II [R1 = R2 = H, R3 = MeO, R4 = 2,3-(MeO)2C6H3; R1 = R2 = MeO, R3 = H, R4 = 4-O2NC6H4, 3,4,5-(MeO)3C6H2, 3,4-(MeO)2C6H3] can be considered as favorable anti-parasitic lead mols. having IC50 and EC50 values in the low-micromolar range, better than the reference drug benznidazole, and low cytotoxicity against Vero cells. The potent compounds were screened in silico against 17 enzymes of T. cruzi and the best scoring were found against Dihydroorotate Dehydrogenase.

European Journal of Medicinal Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vilches-Herrera, Marcelo published the artcileInfluence of the bite natural angle of bidentate diphosphine ligands in the syngas-free branched hydroformylation of β-functionalized olefins, Application In Synthesis of 1205-17-0, the main research area is bidentate diphosphine ligand branched hydroformylation beta olefin.

The correlation between the activity, regio- and chemoselectivity of Rh-diphosphine catalyst and the ligand bite natural angle (βn) in the syngas-free hydroformylation of allyl cyanide was studied. A screening of Xantphos type and diphosphine alkyl ligands with different bite natural angles was studied. Interesting, a switch in the linear to the branch regioselectivity was found. Wide βn favor a linear regioselectivity whereas smaller βn gave the branched aldehyde as the major product. Modification of the substituents at the phosphorus atoms of the diphosphine ligands produced a dramatic change in the hydroformylation. Others β-functionalized olefins were also branched hydroformylated.

Catalysis Communications published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Baricelli, Pablo J. published the artcileHydroformylation of natural olefins with the [Rh(COD)(μ-OMe)]2/TPPTS complex in BMI-BF4/toluene biphasic medium: observations on the interfacial role of CTAB in reactive systems, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is aldehyde preparation hydroformylation natural olefin rhodium catalyst ionic liquid.

The complex [Rh(COD)(μ-OMe)]2 in presence of TPPTS (TPPTS = triphenylphosphinetrisulfonate) was evaluated as catalyst precursor for the in situ hydroformylation of natural olefins (eugenol, estragole and safrole) in biphasic media BMIm-BF4/toluene. Under moderate reaction conditions, the substrates showed the following reactivity order: eugenol > estragole > safrole. The rhodium system showed a high activity and selectivity towards the desired aldehydes. It was found that the use of cetyltrimethylammoniun bromide (CTAB) as phase transfer agent inhibits the hydroformylation reaction. The catalytic phase can be recycled up to four times without evident loss of activity or selectivity. In this work we report the use of an ionic liquid with hydrophilic character, without using water in the reaction medium.

Molecular Catalysis published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chowdari, Naidu S. published the artcileAsymmetric Synthesis of Quaternary α- and β-Amino Acids and β-Lactams via Proline-Catalyzed Mannich Reactions with Branched Aldehyde Donors, Application In Synthesis of 1205-17-0, the main research area is quaternary alpha beta amino acid lactam preparation; Mannich reaction proline catalyzed amino acid beta lactam preparation.

L-Proline-catalyzed direct asym. Mannich reactions of N-PMP protected α-imino Et glyoxylate with various α,α-disubstituted aldehydes affords quaternary β-formyl α-amino acid derivatives with excellent yields and enantioselectivities. The Mannich products are further converted to the corresponding quaternary α- and β-amino acids and β-lactams.

Organic Letters published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Paganelli, Stefano published the artcileSynthesis of fragrances through safrole and isosafrole hydroformylation, SDS of cas: 1205-17-0, the main research area is hydroformylation safrole isosafrole rhodium serum albumin catalyst.

The hydroformylation reaction on safrole and isosafrole has been reinvestigated. An aqueous biphasic process, with a recyclable nanostructured Rh catalyst associated with a human serum albumin, was realized in isosafrole to afford a pleasant new aldehydic odorant mixture containing about 75% of valuable 3-benzo[1,3]dioxol-5-yl-2-methyl-propionaldehyde.

Chimica e l’Industria (Milan, Italy) published new progress about Blood serum albumins Role: CAT (Catalyst Use), USES (Uses) (human). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, SDS of cas: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Marchetti, Mauro published the artcileAqueous biphasic hydrogenations catalyzed by rhodium and iridium complexes modified with human serum albumin, SDS of cas: 1205-17-0, the main research area is biphasic hydrogenations catalysis rhodium iridium complex; catalyst human serum albumin unsaturated aldehyde.

Water soluble complexes derived from the interaction between Rh(CO)2(acac) and [Ir(COD)Cl]2, resp., with human serum albumin (HSA), were employed in the aqueous biphasic hydrogenation of α,β-unsaturated compounds as 2-cyclohexen-1-one (I), 2-butenal (V), 3-phenyl-2-propenal (IX) and 3-aryl-2-methyl-2-propenals (XIII and XVII). Both catalytic systems Rh/HSA and Ir/HSA showed to be very active in the hydrogenation of ketone I even at low temperature and hydrogen pressure; in particular, the rhodium based catalyst showed to be very selective affording exclusively cyclohexanone (II). The α,β-unsaturated aldehydes investigated required higher temperature (up to 60°) and pressure (5 MPa) to obtain good conversions. In this case Rh/HSA resulted to be more active than Ir based catalyst. In all cases both Rh/HSA and Ir/HSA were easily recycled without significant loss of activity.

Applied Catalysis, A: General published new progress about Blood serum albumins Role: CAT (Catalyst Use), USES (Uses) (human). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, SDS of cas: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Terzic-Jovanovic, Natasa published the artcilePalladium on carbon in PEG-400/cyclohexane catalytic system for efficient decarbonylation of aldehydes and its recoverable and recyclable, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is palladium PEG cyclohexane catalytic system decarbonylation aldehyde green chem.

A simple methodol. for the decarbonylation of aldehydes catalyzed by com. available palladium on carbon in a green two-solvent system is reported. Various aromatic, aliphatic and heteroaromatic aldehydes were transformed to the corresponding decarbonylated products in good yields. Product isolation from the reaction mixture is simple in practice, and the catalyst can be reused three times.

Journal of the Serbian Chemical Society published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Guo, Rui-Li published the artcileSynthesis of difluoromethylselenoesters from aldehydes via a radical process, Related Products of isoquinoline, the main research area is difluoromethylselenoester preparation; aldehyde benzyl difluoromethyl selane radical difluoromethylselenolation azobisisobutyronitrile catalyst.

Difluoromethylselenoester compounds RC(O)SeCF2H (R = 4-methylphenyl, furan-2-yl, 1-naphthyl, etc.), another important kind of organoselenium compounds, are reported herein for the first time. They can be efficiently synthesized from aldehydes RCHO and BnSeCF2H. The synthetic method features mild reaction conditions, broad substrate scope, good tolerance of functional groups, and importantly, no metal is involved in the reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yamada, Tomoyuki published the artcileOxidative Coupling of Benzenes with α,β-Unsaturated Aldehydes by the Pd(OAc)2/Molybdovanadophosphoric Acid/O2 System, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is oxidative coupling arene unsaturated aldehyde palladium molybdovanadophosphate catalyst.

The oxidative coupling reaction of benzene with an α,β-unsaturated aldehyde was examined by the combined catalytic system of Pd(OAc)2 with molybdovanadophosphoric acid (HPMoV) under atm. dioxygen. Thus, the reaction of benzene with acrolein under dioxygen (1 atm) by the use of catalytic amounts of Pd(OAc)2 and H4PMo11VO40·26H2O in the presence of dibenzoylmethane as a ligand in propionic acid at 90 °C for 1.5 h afforded cinnamaldehyde in 59% yield and β-phenylcinnamaldehyde in 5% yield. This catalytic system was extended to the direct oxidative coupling through the C-H bond activation of various arenes with acrolein and methacrolein.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem