Category: 1205-17-0

Senthamarai, Thirusangumurugan published the artcileSimple ruthenium-catalyzed reductive amination enables the synthesis of a broad range of primary amines, Category: isoquinoline, the main research area is primary benzylic heterocyclic aliphatic amine preparation; aldehyde ketone reductive amination ruthenium catalyst.

The production of primary benzylic and aliphatic amines, which represent essential feedstocks and key intermediates for valuable chems., life science mols. and materials, is of central importance. Here, the synthesis of this class of amines starting from carbonyl compounds and ammonia by Ru-catalyzed reductive amination using H2 is reported. Key to success for this synthesis is the use of a simple RuCl2(PPh3)3 catalyst that empowers the synthesis of >90 various linear and branched benzylic, heterocyclic, and aliphatic amines under industrially viable and scalable conditions. Applying this catalyst, -NH2 moiety has been introduced in functionalized and structurally diverse compounds, steroid derivatives and pharmaceuticals. Noteworthy, the synthetic utility of this Ru-catalyzed amination protocol has been demonstrated by upscaling the reactions up to 10 g-scale syntheses. Furthermore, in situ NMR studies were performed for the identification of active catalytic species. Based on these studies a mechanism for Ru-catalyzed reductive amination is proposed.

Nature Communications published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Guo, Hai-Ming published the artcileL-Prolinamide-catalyzed direct nitroso aldol reactions of α-branched aldehydes: a distinct regioselectivity from that with L-proline, Category: isoquinoline, the main research area is direct enantioselective nitroso aldol reaction aldehyde nitrosobenzene prolinamide catalyst.

The first direct enantioselective N-nitroso aldol reaction of aldehydes with nitrosobenzene catalyzed by an L-prolinamide derivative is presented; the reactions proceed smoothly furnishing the α-hydroxyamino carbonyl compounds, the otherwise disfavored products, in good yields with up to 64% ee. E.g., L-prolinamide derivative I catalyzed the direct enantioselective N-nitroso aldol reaction of EtCHMeCHO with PhNO to give 53% (-)-EtCMe(CH2OH)NPhOH (46% ee) after NaBH4 reduction

Chemical Communications (Cambridge, United Kingdom) published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lan, Liyuan published the artcilePreparation and odor characteristics of nitriles derived from aldehydes, HPLC of Formula: 1205-17-0, the main research area is aldehyde hydroxylamine hydrochloride reaction; aldoxime preparation dehydration; nitrile preparation odor.

Twenty nitriles, including saturated and unsaturated aliphatic, araliph., and aromatic nitriles, were prepared from the corresponding aldehydes, commonly used as flavors or fragrances. The aldehydes were converted to aldoximes first, which then underwent dehydration by treatment with oxalyl chloride in the presence of a catalytic amount of DMSO. The nitriles were obtained in high yields in most cases. The odor characteristics of the nitriles obtained were evaluated by GC-O. The nitriles present varied characteristic odors, which are usually distinct from those of the corresponding aldehydes.

Flavour and Fragrance Journal published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, HPLC of Formula: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mouries, Virginie published the artcileRadical β-elimination of a sulfinyl group to afford allenes, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is allene preparation; sulfoxide vinyl radical beta elimination.

An unprecedented radical β-elimination of vinyl sulfoxides, e.g. I (R = PhSO), obtained in two steps from the corresponding aldehydes or ketones and Ph vinyl sulfoxide, opened a new route to functionalized allenes, e.g. II. The radical translocation stratagem could also be used to trigger the β-elimination of the sulfinyl radical. Studies on the effect of the nature of the sulfur group on a common precursor showed that vinyl sulfimide I (R = PhSNTs) reacts similarly to vinyl sulfoxide I (R = PhSO), whereas vinyl sulfide I (R = PhS), vinyl sulfone I (R = PhSO2), and vinylsulfinyl imine I (R = PhSONTs) gave no allene II.

European Journal of Organic Chemistry published new progress about Allenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Weber, Stefan published the artcileSelective Hydrogenation of Aldehydes Using a Well-Defined Fe(II) PNP Pincer Complex in Biphasic Medium, Related Products of isoquinoline, the main research area is aldehyde selective hydrogenation iron pincer complex catalyst ionic liquid; Hydrogenation; aldehydes iron; biphasic catalysis; ionic liquids; pincer complexes.

A biphasic process for the hydrogenation of aldehydes was developed using a well-defined iron (II) PNP pincer complex as model system to investigate the performance of various ionic liquids A number of suitable hydrophobic ionic liquids based on the N(Tf)2- anion were identified, allowing to immobilize the iron (II) catalyst in the ionic liquid layer and to facilitate the separation of the desired alcs. Further studies showed that targeted Bronsted basic ionic liquids can eliminate the need of an external base to activate the catalyst.

ChemCatChem published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bruenig, Julian published the artcileChemoselective Supported Ionic-Liquid-Phase (SILP) Aldehyde Hydrogenation Catalyzed by an Fe(II) PNP Pincer Complex, Computed Properties of 1205-17-0, the main research area is alc preparation; aldehyde hydrogenation iron catalyst supported ionic liquid.

A base-tolerant supported ionic-liquid-phase (SILP) system containing a well-defined hydride Fe(II) PNP pincer complex has been prepared, structurally characterized, and used as catalyst in the hydrogenation of aldehydes to alcs. The new SILP catalyst, with the optimum pore filling, was highly active exhibiting TONs and TOFs of up to 1000 and 4000 h-1, resp., under mild conditions (25 °C, 10-50 bar H2 pressure) without significant leaching of both the complex and the IL.

ACS Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Computed Properties of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Glatz, Mathias published the artcileChemoselective Hydrogenation of Aldehydes under Mild, Base-Free Conditions: Manganese Outperforms Rhenium, Application In Synthesis of 1205-17-0, the main research area is hydride manganese rhenium pincer complex catalyst chemoselective hydrogenation aldehyde; alc preparation.

Several hydride Mn(I) and Re(I) PNP pincer complexes were applied as catalysts for the homogeneous chemoselective hydrogenation of aldehydes. Among these, [Mn(PNP-iPr)(CO)2(H)] was found to be one of the most efficient base metal catalysts for this process and represents a rare example which permits the selective hydrogenation of aldehydes in the presence of ketones and other reducible functionalities, such as C=C double bonds, esters or nitriles. The reaction proceeds at room temperature under base-free conditions with catalyst loadings between 0.1 and 0.05 mol% and a hydrogen pressure of 50 bar (reaching TONs of up to 2000). A mechanism which involves an outer-sphere hydride transfer and reversible PNP ligand deprotonation/protonation is proposed. Analogous isoelectronic and isostructural Re(I) complexes were only poorly active.

ACS Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pedersen, Samuel K. published the artcileMain element chemistry enables gas-cylinder-free hydroformylations, Application In Synthesis of 1205-17-0, the main research area is alkene syngas hydroformylation main element chem.

Industrially, aldehydes are produced annually on a multimillion-tonne scale via the hydroformylation of olefins with syngas (CO/H2 mixture). Nonetheless, this transformation has not found frequent use in the laboratory Here, a simple strategy for the concerted generation of syngas from two accessible and crystalline main element compounds with just water as the primary activator for syngas release is reported. By decoupling the syngas formation and consumption via a two-chamber reactor, this low-pressure, low-temperature and near-stoichiometric hydroformylation operates efficiently on a diverse array of terminal olefins without the need for expensive equipment. This approach provides unique opportunities to access aldehydes in a safe and reliable manner with further adaptation to the synthesis of a range of pharmaceuticals and relevant mols. thereof. This strategy is adaptable to carbon isotope labeling as demonstrated by the use of a 13CO releasing mol. It’s anticipated that this hydroformylation approach will provide a complementary toolbox for drug discovery and development.

Nature Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xiao, Zihui published the artcileElectrochemical reduction of functionalized carbonyl compounds: enhanced reactivity over tailored nanoporous gold, Category: isoquinoline, the main research area is reusable nanoporous gold catalyst preparation pore size carbonyl reduction; carbonyl compound diphenylsilane gold nanocatalyst electrochem reduction chemoselective; alc preparation.

The effect of the pore size of nanoporous gold (NPG) on electrochem. reduction of functionalized carbonyl compounds was investigated. NPG with a pore size of ∼30 nm significantly enhanced the reactivity with high chemoselectivity at a low-potential. Typically, p-nitrobenzaldehyde reduction demonstrated a high turnover frequency (TOF) up to 232000 h-1.

Nanoscale published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Weber, Stefan published the artcileReduction of carbonyl compounds via hydrosilylation catalyzed by well-defined PNP-Mn(I) hydride complexes, Quality Control of 1205-17-0, the main research area is alc preparation chemoselective; carbonyl compound reduction hydrosilylation manganese catalyst.

Reduction reactions of unsaturated compounds are fundamental transformations in synthetic chem. In this context, the reduction of polarized double bonds such as carbonyl or C=C motifs can be achieved by hydrogenation reactions. Authors describe here a highly chemoselective Mn(I)-based PNP pincer catalyst for the hydrosilylation of aldehydes and ketones employing polymethylhydrosiloxane (PMHS) as inexpensive hydrogen donor.

Monatshefte fuer Chemie published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Quality Control of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem