Category: 1205-17-0

Alfinito, Eleonora published the artcileHuman olfactory receptor 17-40 as an active part of a nanobiosensor: a microscopic investigation of its electrical properties, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is human olfactory receptor nanobiosensor elec resistance impedance spectrum.

Increasing attention has recently been devoted to protein-based nanobiosensors. The main reason is the huge number of possible technol. applications, ranging from drug detection to early cancer diagnosis. Their operating model is based on protein activation and the corresponding conformational change due to the capture of an external mol., the so-called ligand. Recent measurements, performed with different techniques on the human 17-40 olfactory receptor, revealed a very narrow window of response in respect to the odor concentration This is a crucial point for understanding whether the use of this olfactory receptor as a sensitive part of a nanobiosensor is a good choice. In this paper we investigate the topol. and elec. properties of the human olfactory receptor 17-40 with the objective of providing a microscopic interpretation of available experiments To this purpose, we model the protein by means of a graph that is able to capture the mean features of the 3D backbone structure. The graph is then associated with an equivalent impedance network, able to evaluate the impedance spectra of the olfactory receptor in its native and activated state. We assume a topol. origin of the different protein elec. responses to different ligand concentrations: In this perspective all the exptl. data are collected and interpreted satisfactorily within a unified scheme, also useful for application to other proteins.

RSC Advances published new progress about Biosensors. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vidic, Jasmina published the artcileOn a chip demonstration of a functional role for odorant binding protein in the preservation of olfactory receptor activity at high odorant concentration, Product Details of C11H12O3, the main research area is odorant binding protein olfactory receptor mucus surface plasmon resonance.

The mol. mechanisms underlying odorant detection were investigated using the chip based SPR technique by focusing on the dynamic interactions between transmembrane Olfactory Receptor OR1740, odorant ligands and soluble Odorant-Binding Protein (OBP-1F). The OR1740 present in the lipid bilayer of nanosomes derived from transformed yeasts specifically bound OBP-1F. The receptor preferential odorant ligand helional released bound OBP-1F from the OR-OBP complex, while unrelated odorants failed to do so. OBP-1F modified the functional OR1740 dose-response to helional, from a bell-shaped to a saturation curve, thus preserving OR activity at high ligand concentration This unravels an active role for OBPs in olfaction, in addition to passive transport or a scavenger role. This sensorchip technol. was applied to assessing native OBP-1F in a biol. sample: rat olfactory mucus also displayed significant binding to OR1740 nanosomes, and the addition of helional yielded the dissociation of mucus OBP from the receptor.

Lab on a Chip published new progress about Biosensors. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wasilewski, Tomasz published the artcileDetermination of long-chain aldehydes using a novel quartz crystal microbalance sensor based on a biomimetic peptide, HPLC of Formula: 1205-17-0, the main research area is aliphatic aldehyde quartz crystal microbalance biosensor biomimetic peptide.

This study presents investigation on usefulness of the peptide mimicking HarmOBP7 region as a receptor element of the piezoelec. sensor for selective anal. of long-chain aldehydes. Identification of odorant binding proteins creates new possibilities for design of peptides mimicking binding properties of their volatile compounds Exploration of OBPs and new peptide sequences capable to effectively bind volatile compounds is necessary to enhance artificial olfaction. For the development of biosensors where simple detection is crucial rather than identification of subsequent metabolic activity, the use of sub-protein components (e.g. ligand-binding regions or synthetic peptides) is still escalating. Bearing all this in mind, a segment of a peptide sequence associated with a specific function of HarmOBP7 (involved in binding the long-chain aldehydes) has been designed, synthesized and immobilized on a piezoelec. transducer. The results of in silico investigations were correlated with the exptl. measurements of gas substances. The correlated results confirm a high selectivity of the KLLFDSLTDLKKKMSEC-based sensor with respect to long-chain aliphatic aldehydes including octanal, decanal, undecanal, nonanal and helional. Odorant mols. interact with recognition peptide with specific affinities. The results can throw a new light on the possibility of synthetic peptide application as a receptor layer in biosensors in odorants anal.

Microchemical Journal published new progress about Biomarkers. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, HPLC of Formula: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Clausen, Per Axel published the artcileBiocidal spray product exposure: Measured gas, particle, and surface concentrations compared with spray model simulations, Synthetic Route of 1205-17-0, the main research area is biocidal spray product simulation air pollution healt risk; Aerosols; ConsExpo Web; disinfectant; modeling.

The purpose of the study was to compare measured air and surface concentrations after application of biocidal spray products with concentrations simulated with the ConsExpo Web spray simulation tool. Three different biocidal spray products were applied in a 20 m3 climate test chamber with well-controlled environmental conditions (22 ± 1°C, 50 ± 2% relative humidity, and air exchange rate of 0.5 h-1). The products included an insect spray in a pressurized spray can, another insect spray product, and a disinfectant, the latter two applied sep. with the same pumped spray device. The measurements included released particles, airborne organic compounds in both gas and particle phase, and surface concentrations of organic compounds on the wall and floor in front of the spraying position and on the most remote wall. Spraying time was a few seconds and the air concentrations were measured by sampling on adsorbent tubes at 9-13 times points during 4 h after spraying. The full chamber experiment was repeated 2-3 times for each product. Due to sedimentation the concentrations of the particles in air decayed faster than explained by the air exchange rate. In spite of that, the non-volatile benzalkonium chlorides in the disinfectant could be measured in the air more than 30 min after spraying. ConsExpo Web simulated concentrations that were about half of the measured concentrations of the active substances when as many as possible of the default simulation parameters were replaced by the exptl. values. ConsExpo Web was unable to simulate the observed faster decay of the airborne concentrations of the active substances, which might be due to underestimation of the gravitational particle deposition rates. There was a relatively good agreement between measured surface concentrations on the floor and calculated values based on the dislodgeable amount given in the selected ConsExpo Web scenarios. It is suggested to always supplement simulation tool results with practical measurements when assessing the exposure to a spray product.

Journal of Occupational and Environmental Hygiene published new progress about Adsorption. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vidic, Jasmina published the artcileGold Surface Functionalization and Patterning for Specific Immobilization of Olfactory Receptors Carried by Nanosomes, Product Details of C11H12O3, the main research area is gold surface functionalization patterning immobilization olfactory receptor carried nanosome.

There is substantial interest in engineering solid supports to achieve functional immobilization of membrane receptors both for investigation of their biol. function and for the development of novel biosensors. Three simple and practical strategies for immobilization of a human olfactory receptor carried by nanosomes are presented. The basis of the functionalization of solid gold surfaces is a self-assembled monolayer (SAM) containing biotinyl groups. Biotinyl groups are subsequently used to attach neutravidin and then biotinylated monoclonal antibody directed against the receptor to allow its specific grafting. Surface plasmon resonance technique is implemented for real-time monitoring of step-by-step surface functionalization and, in addition, for testing the functional response of immobilized olfactory receptors. The authors show that OR1740 is functional when immobilized via a tag attached to its C-terminus, but not via its N-terminus. Finally, the authors demonstrate that gold surfaces can be patterned by the SAMs tested using microcontact printing. AFM images of immobilized nanosomes onto a patterned surface suggest that small nanosomes flatten and fuse into larger vesicles but do not merge into a continuous layer. The whole study emphasizes the outstanding performances of the BAT/PEGAT SAM, which could be useful for developing on-a-chip sensor formats for membrane receptor investigations and use.

Analytical Chemistry (Washington, DC, United States) published new progress about Adsorption. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Csendes, Zita published the artcileInfluence of the Ionic Liquid on the Activity of a Supported Ionic Liquid Phase FeII Pincer Catalyst for the Hydrogenation of Aldehydes, Related Products of isoquinoline, the main research area is silica supported ionic liquid iron pincer catalysis aldehyde hydrogenation; Hydrogenation; Ionic liquids; Iron; Supported catalysts; Sustainable chemistry.

The catalytic hydrogenation of different aldehydes to the corresponding alcs. was investigated using an FeII hydride pincer complex as catalyst in the supported ionic liquid phase (SILP) reaction mode. Two different ionic liquids of the type [X4441][NTf2] with X=N or P were applied with mesoporous silica gel as support, which was coated first with a chemisorbed monolayer of the corresponding modified IL to remove acidic surface OH-groups and to prevent IL leaching. Quant. conversion with turn-over frequencies in the order of 1000 h-1 were obtained for various aromatic and heteroaromatic aldehydes and highly selective aldehyde reduction was observed also for substrates containing reducible C=C bonds. Aldehydes with longer aliphatic chains or cycloalkyl substituents, however, showed no conversion here, in contrast to a previous study with an imidazolium-based ionic liquid These differences were ascribed primarily to differences in substrate/ionic liquid interactions. Whereas [N4441][NTf2] and [P4441][NTf2] gave essentially identical results for different substrates in single-batch reactions, prolonged use of the catalyst in repeated reaction cycles lead to a quick drop-off in catalyst activity in [P4441][NTf2], but a continuous, quant. conversion in [N4441][NTf2].

European Journal of Inorganic Chemistry published new progress about Adsorption. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tumskiy, Roman S. published the artcileDocking and antibacterial activity of novel nontoxic 5-arylidenepyrimidine-triones as inhibitors of NDM-1 and MetAP-1, Related Products of isoquinoline, the main research area is docking antibacterial activity nontoxic arylidenepyrimidine trione inhibitor NDM MetAP; 5-arylidene barbituric acids; 5-arylidenepyrimidine-2,4,6(1H,3H,5H)-triones; ADMET; New Delhi metallo-β-lactamase-1; antibacterial activity; cytotoxicity; methionine aminopeptidase-1; molecular docking.

Antibiotic resistance, which occurs through the action of metallo-β-lactamases (NDM-1), is a serious problem in the treatment of infectious diseases. Therefore, the discovery of new NDM-1 inhibitors and promising antibacterial agents as inhibitors of alternative targets (MetAP-1) is important. In this study, a virtual library of 5-arylidene barbituric acids was created and mol. docking was performed for identification of novel possible inhibitors of NDM-1 and MetAP-1. Antibacterial activity (agar well-diffusion assay) and cytotoxicity (alamarBlue assay) of perspective compounds were evaluated. Pharmacokinetic profiles and mol. properties were predicted. We have identified possible novel inhibitors of NDM-1 and MetAP-1 with bacteriostatic activity, most of which are not cytotoxic and have potential excellent drug-likeness properties.

Future Medicinal Chemistry published new progress about Absorption. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Api, Anne Marie published the artcileEvaluation of the developmental toxicity of α-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde in rats, SDS of cas: 1205-17-0, the main research area is developmental toxicity methylene dioxyhydrocinnamic aldehyde.

The developmental toxicity of a-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde (MMDHCA), a widely used fragrance ingredient, was evaluated for developmental toxicity in Sprague-Dawley rats (25/group; cesarean-sectioning identified 21 to 25 pregnant rats/group). Oral dosages of 0 (corn oil), 62, 125, or 250 mg/kg/day were administered by gavage on days 7 through 17 of gestation (GDs 7 through 17). Rats were observed for viability, clin. signs, body weights, and feed consumption. Necropsy and cesarean sectioning occurred on GD 21. Uteri were examined for number and distribution of implantations, live and dead fetuses, and early and late resorptions. Numbers of corpora lutea were also recorded. Fetuses were weighed and examined for gender, gross external changes, and soft tissue or skeletal alterations. Anal. of dosage preparations verified calculated dosages ±10%. No deaths occurred. Excessive salivation occurred in all groups, but the incidence was increased at 250 mg/kg/day. The 250 mg/kg/day dosage also was associated with a significant increase in the incidences of a clear, red or yellow perioral and/or red perivaginal substance and significant reductions in mean feed consumption and body weight gains (11.6% and 7.4%, resp.) during the entire dosage period. No gross changes attributable to MMDHCA were observed at necropsy. Cesarean section or litter parameters, as well as fetal alterations, were not affected by MMDHCA at 250 mg/kg/day or either of the lower dosages tested. Based on these data, maternal and developmental no-observable-effect levels (NOAELs) of 125 and °250 mg/kg/day, resp., were established for MMDHCA. It is concluded that MMDHCA is not a developmental toxicant in rats under the conditions of this study and dosing regimen.

International Journal of Toxicology published new progress about Body weight. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, SDS of cas: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Guo, ZhenZhong published the artcileA novel platform based on immobilized histidine tagged olfactory receptors, for the amperometric detection of an odorant molecule characteristic of boar taint, HPLC of Formula: 1205-17-0, the main research area is olfactory receptor boar taint square wave voltammetry fluorescence microscopy; Fluorescence microscopy; Functional immobilization; Olfactory receptor; Square wave voltammetry.

We report a dose-dependent detection of androstenone in solution, as one of the boar taint compounds, based on related OR7D4 olfactory receptors immobilized on a gold electrode through their 6-His tag and NTA-copper complex, as visualized through fluorescence microscopy. Square wave voltammetry (SWV) is for the first time, the method used to monitor the olfactory receptor/odorant recognition process. The relative variation of the Cu(I)-Cu(II) current peak increases linearly vs. log (concentration of androstenone) from 10-14 M to 10-4 M, in buffer solution Neg. tests were performed, using an unrelated odorant, helional, itself a ligand of OR 1740. Cross-selectivity was also tested after immobilization of OR 1740.

Food Chemistry published new progress about Amperometry. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, HPLC of Formula: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ashikari, Tsubasa published the artcileSalicylaldehyde Suppresses IgE-Mediated Activation of Mast Cells and Ameliorates Anaphylaxis in Mice, Product Details of C11H12O3, the main research area is salicylaldehyde IgE mast cell ameliorates anaphylaxis; FcεRI; IgE; anaphylaxis; mast cells; salicylaldehyde.

Mast cells (MCs) play key roles in IgE-mediated immunoresponses, including in the protection against parasitic infections and the onset and/or symptoms of allergic diseases. IgE-mediated activation induces MCs to release mediators, including histamine and leukotriene, as an early response, and to produce cytokines as a late phase response. Attempts have been made to identify novel antiallergic compounds from natural materials such as Chinese medicines and food ingredients. We herein screened approx. 60 compounds and identified salicylaldehyde, an aromatic aldehyde isolated from plant essential oils, as an inhibitor of the IgE-mediated activation of MCs. A degranulation assay, flow cytometric analyses, and enzyme-linked immunosorbent assays revealed that salicylaldehyde inhibited the IgE-mediated degranulation and cytokine expression of bone-marrow-derived MCs (BMMCs). The salicylaldehyde treatment reduced the surface expression level of FcεRI, the high affinity receptor for IgE, on BMMCs, and suppressed the IgE-induced phosphorylation of tyrosine residues in intercellular proteins, possibly Lyn, Syk, and Fyn, in BMMCs. We also examined the effects of salicylaldehyde in vivo using passive anaphylaxis mouse models and found that salicylaldehyde administration significantly enhanced the recovery of a reduced body temperature due to systemic anaphylaxis and markedly suppressed ear swelling, footpad swelling, and vascular permeability in cutaneous anaphylaxis.

International Journal of Molecular Sciences published new progress about Anaphylaxis. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem