Category: 1205-17-0

Menon, A. Nirmala published the artcileStudies on the volatiles of cardamom (Elleteria cardamomum), Product Details of C11H12O3, the main research area is essential oil flavor aroma cardamom.

The original aroma compounds present in cardamom were isolated by Amberlite XAD-2 column chromatog. from fresh green cardamom and termed as OFFC (original flavor of fresh cardamom), distilling fresh green cardamom DOFC (distilled oil of fresh cardamom) and distilling com. cardamom DOCC (distilled oil of com. cardamom). They were analyzed by HRGC and GC-MS techniques. The major compounds did not show much variations in these samples, viz., 1,8 cineole and α-terpinyl acetate. Many sesquiterpene hydrocarbons were found to be present in the DOFC and not in OFFC. However, there were marked differences in the contents of other components. It was also observed that some new compounds were present in the oil of cardamom.

Journal of Food Science and Technology published new progress about Elettaria cardamomum. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wetzel, Christian H. published the artcileSpecificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus laevis oocytes, Synthetic Route of 1205-17-0, the main research area is olfactory receptor recombinant expression Xenopus oocyte.

Here, we provide evidence for functional expression of a human olfactory receptor protein (OR17-40) and show that recombinant olfactory receptors can be functionally expressed in heterologous systems. A mixture of 100 different odorants (Henkel 100) elicited a transient increase in intracellular [Ca2+] in human embryonic kidney 293 (HEK293) cells stably or transiently transfected with the plasmid pOR17-40. By subdividing the odorant mixture into progressively smaller groups, we identified a single component that represented the only effective substance: helional. Only the structurally closely related mol. heliotroplyacetone also activated the receptor. Other compounds, including piperonal, safrole, and vanillin, were completely ineffective. Mock-transfected cells and cells transfected with other receptors showed no change in intracellular [Ca2+] in response to odor stimulation. We were also able to functionally express OR17-40 in Xenopus laevis oocytes. Coexpression of a “”reporter”” channel allowed measurement of the response of oocytes injected with the cRNA of the human receptor to the odor mixture Henkel 100. The effective substances were the same (helional, heliotropylacetone) as those identified by functionally expressing the receptor in HEK293 cells and were active at the same, lower micromolar concentration These findings open the possibility of now characterizing the sensitivity and specificity of many, if not all, of the hundreds of different human olfactory receptors.

Journal of Neuroscience published new progress about Human cell line 293T. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bello, Patrice published the artcileUpping fragrance intensity via cyclodextrins: expert noses and headspace/SPME-GC confirm effects, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is cosmetics cyclodextrin perfume skin fragrance volatile compound.

The aim of the study is efficacy and potential benefits of cyclodextrins in delivering fragrances with and without CDs were compared using headspace/solid-phase microextraction gas chromatog. All measurements and assessments were carried out on the volar forearms(s) of one Caucasian subject in a controlled environment: 25 ± 1°C and 30% ± 5% relative humidity. GC test protocol: The GC test protocol included: 1) washing the subject′s forearm three times with ethanol and allowing it to air-dry: 2) spraying 200 mg of a test EdT three times and allowing it to air-dry for 2 min; 3) a 20-min stabilization phase: 4) a 20-min extraction phase; 5) a 2-min desorption phase; and 6) CO-MS anal. To trap gas, a glass bell jar (105 cm3) was used, along with a syringe incorporating an SPME fiber in polydimethylsiloxane (PDMS), to absorb volatile compounds Olfactory test: The olfactory test procedure involved washing both of the subject′s forearms three times with ethanol and allowing them to air-dry, then spraying -200 mg of a test EdT three times and allowing it to air-dry for 2 min. Twenty perfume experts then smelled the two forearms to make assessments. Measurements and assessments were performed every- three hours to determine the perfume evolution on skin. Results from the headspace/SPME-GC anal. indicated that initially (T0), the fragrance samples with and without CD had the same perfume intensity. Three hours later, however (T+3 h), the CD-containing perfume was approx. 50% more intense than the perfume without CD.

Perfumer & Flavorist published new progress about Cosmetic fragrance products. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Nicastro, Gloria published the artcileControlled Hydrolysis of Odorants Schiff Bases in Low-Molecular-Weight Gels, Synthetic Route of 1205-17-0, the main research area is Schiff base gels odorants hydrolysis; Schiff base; fragrance; gel; hydrolysis; perfumery; self-assembly.

Imines or Schiff bases (SB) are formed by the condensation of an aldehyde or a ketone with a primary amine, with the removal of a water mol. Schiff bases are central mols. in several biol. processes for their ability to form and cleave by small variation of the medium. We report here the controlled hydrolysis of four SBs that may be applied in the fragrance industry, as they are profragrances all containing odorant mols.: Me anthranilate as primary amine, and four aldehydes (cyclamal, helional, hydroxycitronellal and triplal) that are very volatile odorants. The SB stability was assessed over time by HPLC-MS in neutral or acidic conditions, both in solution and when trapped in low mol. weight gels. Our results demonstrate that it is possible to control the hydrolysis of the Schiff bases in the gel environment, thus tuning the quantity of aldehyde released and the persistency of the fragrance.

International Journal of Molecular Sciences published new progress about Cosmetic fragrance products. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cetti, Jonathan published the artcileModeling the Vapor-Liquid Equilibria of Ionic Liquids Containing Perfume Raw Materials, COA of Formula: C11H12O3, the main research area is model vapor liquid equilibrium ionic perfume.

In this work, the vapor-liquid equilibrium of binary and multinary systems comprise perfume raw materials and ionic liquids have been computed using two different models: COSMO-RS, a solvation model, and UNIFAC, a group contribution method. For systems already well-known in the literature, a comparison with exptl. data was performed, and good agreement was observed with both models. Although UNIFAC was not applicable to nonparametrized ionic liquids, COSMO-RS proved very reliable in predicting the vapor-liquid equilibrium of solutions of perfume raw materials in new-to-the-world ionic liquids This opens the door for the prediction and modeling of new formulations for novel consumer products, prior to embarking on detailed exptl. investigations.

Journal of Chemical & Engineering Data published new progress about Cosmetic fragrance products. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, COA of Formula: C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Talzi, V. P. published the artcileA 13C and 1H NMR analysis of perfumes, Quality Control of 1205-17-0, the main research area is perfume carbon 13 NMR characterization.

Composition of a series of formulations used in Russia for production of various perfumes, among them car air fresheners, was studied by 13C and 1H NMR. The main components were identified, approx. compositions of several perfumes were determined, and spectral data are given. These spectral data can be used for prompt anal. for composition of com. odorants with the aim of monitoring their quality and hygienic characteristics.

Russian Journal of Applied Chemistry published new progress about Cosmetic fragrance products. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Quality Control of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wakayama, Hideki published the artcileMethod for Predicting Odor Intensity of Perfumery Raw Materials Using Dose-Response Curve Database, Quality Control of 1205-17-0, the main research area is odor intensity perfumery raw dose database.

The main purpose of this study is to facilitate fragrance development on the basis of scientific knowledge. To this end, data on 314 perfumery raw materials (PRMs) showing the relationship between PRM odor intensity and gas concentration were obtained, and a calculation model for the data was then developed with the following features: (1) maximum PRM coverage, (2) calculating values implying odor intensity from only arbitrary gas concentration, and (3) estimating odor intensity from the calculated values directly and easily. To verify the prediction accuracy of this model, the predicted odor intensity was compared with the evaluated value for both single component and a mixture, and the same degree of root mean square error (RMSE) was confirmed. RMSE in the single component was 6.22 while that in the mixture was 6.69. Thus, the odor intensity of a PRM or mixture can be predicted from arbitrary gas concentrations

Industrial & Engineering Chemistry Research published new progress about Citrus aurantiifolia (oxide). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Quality Control of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Matzel, Philipp published the artcileSynthesis of β-Chiral Amines by Dynamic Kinetic Resolution of α-Branched Aldehydes Applying Imine Reductases, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is imine reductase dynamic kinetic resolution.

Imine reductases (IREDs) allow the one-step preparation of optically active secondary and tertiary amines by reductive amination of ketones. Until now, mainly α-chiral amines have been prepared by this route. In this study, we explored the possibility of synthesizing β-chiral amines, a class of compounds which is also frequently found as structural motif in pharmaceuticals but much more challenging to prepare due to the following reasons: (i) The aldehyde substrate already contains the chiral center and needs to be racemized to enable full conversion. (ii) Because the intermediate imine bears the stereo center two carbon atoms remote to the imine nitrogen, it is more challenging to achieve high enantioselectivity compared to α-chiral amine synthesis. For investigating the proof of concept, we first confirmed that different IREDs are able to convert a variety of α-branched aldehydes when combined with five different amine substrates. The IRED from Streptomyces ipomoeae was a suitable enzyme facilitating the dynamic kinetic resolution of 2-phenylpropanal and a substituted 2-methyl-3-phenylpropanal: the corresponding N-methylated β-chiral amines were obtained with >95 % conversion and 78 and 95 %ee. Other amines were formed with low to moderate enantiomeric excess. This exemplifies the potential of IREDs for the one-step synthesis of secondary β-chiral amines, but also the challenge to identify highly selective enzymes for a desired amine product.

ChemCatChem published new progress about Biochemical reaction kinetics. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Oh, Eun Hae published the artcileOdorant detection using liposome containing olfactory receptor in the SPR system, HPLC of Formula: 1205-17-0, the main research area is odorant liposome olfactory receptor surface plasmon resonance system.

The binding of odorant to human olfactory receptor (hOR) is the first step of the odor-sensing mechanism in human olfactory system. It is well known that humans recognize and discriminate smell through a signaling cascade initiated by the binding of many different kinds of odorant mols. to approx. 390 different types of hORs but most ORs remain orphans. Hence, the identification of odorant mols. that bind to orphan hORs and the characterization of hORs is required to discover the function of orphan hORs. For this purpose, various heterologous expression systems have been developed but the low expression efficiency of hORs has been an obstacle. Moreover, the cell-based odorant detection system was easily influenced by environmental conditions. In this study, we expressed human olfactory receptor hOR3A1 in an Escherichia coli expression system for high expression efficiency and stable odorant detection. The hOR3A1, which is mainly produced as an inclusion body in E. coli, was partially purified and reconstituted using lipid/detergent mixed micelles for stabilizing the structure of hOR3A1, which is a transmembrane protein. The reconstituted hOR3A1 was immobilized on the gold surface of surface plasmon resonance (SPR), and the function of the odorant detection was analyzed. The results demonstrate that the reconstituted hOR3A1 can detect the specific odorant, helional, in a dose-dependent manner and can also discriminate it from odorants of a similar structure. Such a reconstituted olfactory receptor produced by E. coli expression system, can be useful as an efficient sensing material for the protein-based odorant detection system using various detection devices as well as using SPR.

Sensors and Actuators, B: Chemical published new progress about Critical micelle concentration. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, HPLC of Formula: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Souers, Andrew J. published the artcileSynthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is G protein coupled receptor MCH antagonist alkoxy quinolinamine preparation; antiobesity agent melanin concentrating hormone receptor alkoxy quinolinamine preparation; obesity MCH antagonist melanin concentrating hormone receptor alkoxyquinolinamine preparation.

Prior SAR studies on 2-amino-8-alkoxyquinoline MCHr1 antagonists demonstrated that compounds with acyclic amide-containing sidechains displayed exceptional binding and functional potency, but negligible CNS penetration. Related analogs with acyclic benzylamine-containing sidechains showed greatly improved CNS exposure, but suffered in functional potency. In this report, it was demonstrated that cyclization of these benzylic amine sidechains affords compounds that combine the best elements of potency and CNS penetration among this class of antagonists. This is exemplified by 8-[[(3S)-1-(2,2-difluoro-1,3-benzodioxol-5-yl)-3-pyrrolidinyl]oxy]-2-quinolinamine (I), which has sub-nanomolar MCHr1 binding affinity, good functional potency, and excellent CNS exposure over 24 h.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiobesity agents (antagonists). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem