Category: 1205-17-0

Cloutier, Melissa published the artcileDrastic fluorine effect: complete reversal of the selectivity in the Au-catalyzed hydroalkoxylation reaction of fluorinated haloalkynes, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is regioselective gold catalyzed hydroalkoxylation halodifluoroalkyne.

The gold-catalyzed hydration reaction of haloalkynes is highly regioselective producing 2-halomethylketones as the sole products. Herein, we document a drastic fluorine effect where the reaction of 1-halo-3,3-difluoroalkynes as substrates leads to a complete reversal of selectivity and produces 3,3-difluoro esters as the unique products. Thus, e.g., alkyne I �ester II (74% isolated) in presence of (Johnphos)AuCl and AgOTf in THF/MeOH.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkoxylation catalysts, reductive (regioselective). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ito, Hajime published the artcileCopper(I)-catalyzed stereoselective defluoroborylation of aliphatic gem-difluoroalkenes, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is copper catalyzed stereoselective defluoroborylation aliphatic gem difluoroalkene; monofluoro substituted borylalkene stereoselective preparation.

This study reports a method for the stereoselective copper(I)-catalyzed defluoroborylation of aliphatic gem-difluoroalkenes to afford (Z)-monofluoro-substituted borylalkenes. Gem-difluoro- alkenes bearing a variety of functional groups were efficiently borylated with high stereoselectivity. A theor. study of the reaction mechanism is also described.

Chemistry Letters published new progress about Borylation (stereoselective, defluoroborylation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Betke, Tobias published the artcileCyanide-Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach, Quality Control of 1205-17-0, the main research area is aldoxime dehydratase chiral nitrile synthesis; asymmetric catalysis; biocatalysis; enantioselectivity; nitriles; oximes.

A cyanide-free platform technol. for the synthesis of chiral nitriles by biocatalytic enantioselective dehydration of a wide range of aldoximes is reported. The nitriles were obtained with high enantiomeric excess of >90 % ee (and up to 99 % ee) in many cases, and a “”privileged substrate structure”” with respect to high enantioselectivity was identified. Furthermore, a surprising phenomenon was observed for the enantiospecificity that is usually not observed in enzyme catalysis. Depending on whether the E or Z isomer of the racemic aldoxime substrate was employed, one or the other enantiomer of the corresponding nitrile was formed preferentially with the same enzyme.

Angewandte Chemie, International Edition published new progress about Dehydration reaction (enzyme, stereoselective). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Quality Control of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Triandafillidi, Ierasia published the artcilePhotocatalytic Synthesis of γ-Lactones from Alkenes: High-Resolution Mass Spectrometry as a Tool To Study Photoredox Reactions, Product Details of C11H12O3, the main research area is gamma lactone regioselective preparation; terminal disubstituted alkene regioselective photoredox cycloaddition iodoacetate ruthenium catalyst; mechanism photoredox cycloaddition iodoacetate alkene detection intermediate mass spectrometry.

γ-Lactones such as 5-octyl-γ-butyrolactone were prepared regioselectively in 40-98% yields by photoredox cycloaddition of iodoacetic acid, bromoacetic acid, or 2-bromopropanoic acid with alkenes in the presence of Ru(bpy)3Cl2 and sodium ascorbate in MeOH/MeCN at ambient temperature Intermediates in the cycloaddition of iodoacetic acid and 1-allyloxy-4-fluorobenzene were detected by high-resolution mass spectrometry (HRMS) and provided evidence for a proposed mechanism.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Paganelli, Stefano published the artcileAqueous biphasic hydrogenations catalyzed by new biogenerated Pd-polysaccharide species, SDS of cas: 1205-17-0, the main research area is aqueous hydrogenation catalyzed biogenerated palladium polysaccharide species.

A palladium species bound to an exopolysaccharide (Pd-EPS) was obtained from alive bacterial cells of Klebsiella oxytoca BAS-10 grown in static mode in the presence of Pd(NO3)2. Pd-EPS, after isolation and purification, was used as catalyst in the aqueous biphasic hydrogenation either of unfunctionalyzed olefins, as styrene, 1-octene and 1,3-diisopropenylbenzene, or of some α,β-unsaturated aldehydes. The catalytic system was very active under mild reaction conditions and its activity was maintained in some recycle experiments Even more efficient was the “”activated Pd-EPS””, obtained by a pre-treatment of Pd-EPS with 1 MPa of H2 at 30 °C for 21 h; while Pd-EPS originally contains only Pd(II), as demonstrated by XPS measurements, the activated catalyst shows the presence of both Pd(II) and Pd(0) in the ratio 1.9/1. The two catalytic systems show different structures at TEM observations evidencing the transformation of electron ultradense nanoaggregates (Pd-EPS) into jagged microaggregates (“”activated Pd-EPS””).

Applied Catalysis, A: General published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, SDS of cas: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Voutyritsa, Errika published the artcileExpanding the scope of photocatalysis: atom transfer radical addition of bromoacetonitrile to aliphatic olefins, HPLC of Formula: 1205-17-0, the main research area is photocatalysis radical addition reaction bromocyanomethylation optimization olefins.

An efficient photocatalyzed bromocyanomethylation of alkenes is reported. Among a range of organocatalysts and metal complexes, Ir(ppy)3 proved to be the best photocatalyst in promoting the addition of BrCH2CN to olefins. This photocatalytic atom transfer protocol can be expanded into a wide substrate scope of aliphatic olefins bearing various functional groups, leading to the corresponding products in good to excellent yields. In addition, linchpin catalysis was developed, since the bromo group can undergo further transformation into useful functional groups, such as the synthesis of amino acids.

ChemCatChem published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, HPLC of Formula: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

He, Yuli published the artcileTerminal-Selective C(sp3)-H Arylation: NiH-Catalyzed Remote Hydroarylation of Unactivated Internal Olefins, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is nickel hydride remote alkene isomerization hydroarylation unactivated olefin; alkyl heteroaryl aryl derivative preparation.

A terminal-selective migratory hydroarylation of unactivated olefins was developed though a NiH-catalyzed alkene isomerization-hydroarylation relay process. This sp3 C-H arylation was achieved with a simple pyrox ligand under mild conditions. The practicality and synthetic flexibility of the method is highlighted by the successful regioconvergent conversion of isomeric mixtures of alkenes to value-added linear arylation products on a gram scale.

Organometallics published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lin, Zhiyang published the artcileSynthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C-F and C-O Bond Cleavage, Product Details of C11H12O3, the main research area is alkene trifluoromethyl acetal nickel allylic defluorinative coupling reaction catalyst; difluoroalkene preparation.

By merging C-O and C-F bond cleavage in cross-electrophile coupling, we developed a method for efficient synthesis of gem-difluoroalkenes with an alkoxy-substituent on the homoallylic position using easily accessible acetals as coupling partners with α-trifluoromethyl alkenes. Remarkably, this Ni-catalyzed allylic defluorinative cross-coupling reaction demonstrates high tolerance of a wide range of sensitive functional groups and proves to be applicable in late-stage functionalization of structurally complex compounds

ACS Catalysis published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ke, Lei published the artcileCatalytic Selective Oxidative Coupling of Secondary N-Alkylanilines: An Approach to Azoxyarene, Formula: C11H12O3, the main research area is azoxyarene preparation anticancer catalyst oxidative coupling secondary alkylaniline.

Azoxyarenes are among important scaffolds in organic mols. Direct oxidative coupling of primary anilines provides a concise fashion to construct them. However, whether these scaffolds can be prepared from secondary N-alkylanilines is not well explored. Here, the authors present a catalytic selective oxidative coupling of secondary N-alkylaniline to afford azoxyarene with tungsten catalyst under mild conditions. In addition, azoxy can be viewed as a bioisostere of alkene and amide. Several “”azoxyarene analogs”” of the corresponding bioactive alkenes and amides showed comparable promising anticancer activities.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Evdokimov, Nikolai M. published the artcileOne-Step, Three-Component Synthesis of Pyridines and 1,4-Dihydropyridines with Manifold Medicinal Utility, Formula: C11H12O3, the main research area is aldehyde thiol malononitrile cyclization pyridine enamino nitrile preparation.

Privileged medicinal scaffolds based on the structures of 2-amino-3,5-dicyano-6-sulfanylpyridines and the corresponding 1,4-dihydropyridines have been prepared via a single-step, three-component reaction of structurally diverse aldehydes with various thiols and malononitrile. Mechanistic studies revealed that 1,4-dihydropyridines undergo oxidation by the intermediate Knoevenagel adducts rather than by air oxygen. Although the latter process undermines the yields of pyridines, it results in the formation of substituted enamino nitriles, promising antiinflammatory agents.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem