Cloutier, Melissa published the artcileDrastic fluorine effect: complete reversal of the selectivity in the Au-catalyzed hydroalkoxylation reaction of fluorinated haloalkynes, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is regioselective gold catalyzed hydroalkoxylation halodifluoroalkyne.
The gold-catalyzed hydration reaction of haloalkynes is highly regioselective producing 2-halomethylketones as the sole products. Herein, we document a drastic fluorine effect where the reaction of 1-halo-3,3-difluoroalkynes as substrates leads to a complete reversal of selectivity and produces 3,3-difluoro esters as the unique products. Thus, e.g., alkyne I â?ester II (74% isolated) in presence of (Johnphos)AuCl and AgOTf in THF/MeOH.
Chemical Communications (Cambridge, United Kingdom) published new progress about Alkoxylation catalysts, reductive (regioselective). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem