Selective Ortho Methylation of Nitroheteroaryls by Vicarious Nucleophilic Substitution was written by Achmatowicz, Michal;Thiel, Oliver R.;Gorins, Gilles;Goldstein, Corinne;Affouard, Caroline;Jensen, Randy;Larsen, Robert D.. And the article was included in Journal of Organic Chemistry in 2008.Related Products of 188121-31-5 This article mentions the following:
An efficient and scalable three-step one-pot approach to 6-methyl-5-nitroisoquinoline from inexpensive 5-nitroisoquinoline, utilizing the vicarious nucleophilic substitution (VNS) as a key step, is described. The optimized reaction conditions can be applied to a limited number of other aromatic and heteroaromatic nitro compounds Attempts to understand the observed selectivity in the VNS step led to the discovery of two new reaction pathways under VNS conditions, one leading to an isoxazole and the other resulting in the formal cyclopropanation of an aromatic nitro compound In the experiment, the researchers used many compounds, for example, 6-Methyl-5-nitroisoquinoline (cas: 188121-31-5Related Products of 188121-31-5).
6-Methyl-5-nitroisoquinoline (cas: 188121-31-5) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Related Products of 188121-31-5
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem