Category: 342899-38-1

Sawanishi, Hiroyuki’s team published research in Heterocycles in 1982 | CAS: 342899-38-1

3-Chloroisoquinolin-4-amine(cas: 342899-38-1) belongs to isoquinoline.Electric Literature of C9H7ClN2 Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.

Electric Literature of C9H7ClN2On June 1, 1982, Sawanishi, Hiroyuki; Hirai, Toyoko; Tsuchiya, Takashi published an article in Heterocycles. The article was 《Photolysis of pyridyl, quinolyl, and isoquinolyl azides in hydrohalic acids》. The article mentions the following:

Irradiation of 4-azidopyridine and -quinoline in 6 N HCl or HBr at room temperature gave the corresponding 3-amino-4-halo compound (10-15% yield) and 4-aminopyridine and 4-aminoquinoline (25-35% yield). On the other hand, similar treatment of 4 azidopyridine N-oxide and 4-azidoquinoline N-oxide gave the corresponding 4-amino-3-halo compounds (80-95% yields). Also, similar treatment of 3-azidoquinoline and 4-azidoisoquinoline, both the free bases and the N-oxides, gave results similar to those for 4-azidopyridine N-oxide. Photolysis of 4-azidopyridine and -quinoline occurred through azirine of azacycloheptatetraene intermediates. The photolysis of 4-azidopyridine N-oxide and 4-azidoquinoline N-oxide occurred through nitrenium ion intermediates.3-Chloroisoquinolin-4-amine(cas: 342899-38-1Electric Literature of C9H7ClN2) was used in this study.

3-Chloroisoquinolin-4-amine(cas: 342899-38-1) belongs to isoquinoline.Electric Literature of C9H7ClN2 Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Bakke, J. M.’s team published research in Journal of Heterocyclic Chemistry in 2001 | CAS: 342899-38-1

3-Chloroisoquinolin-4-amine(cas: 342899-38-1) belongs to isoquinoline.SDS of cas: 342899-38-1 Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.

Bakke, J. M.; Riha, J. published an article on February 28 ,2001. The article was titled 《Preparation of 4-substituted 3-amino-2-chloropyridines, synthesis of a nevirapine analog》, and you may find the article in Journal of Heterocyclic Chemistry.SDS of cas: 342899-38-1 The information in the text is summarized as follows:

A new method for preparing 3-amino-2-chloropyridines with a substituent (Me, Ph, carboxamide, methoxycarbonyl, acetyl, benzoyl and cyano) at the 4-position was developed. An isoquinoline analog of the reverse transcriptase inhibitor Nevirapine was prepared from 3-chloro-4-isoquinolinamine. The experimental part of the paper was very detailed, including the reaction process of 3-Chloroisoquinolin-4-amine(cas: 342899-38-1SDS of cas: 342899-38-1)

3-Chloroisoquinolin-4-amine(cas: 342899-38-1) belongs to isoquinoline.SDS of cas: 342899-38-1 Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

More research is needed about 342899-38-1

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: isoquinoline, you can also check out more blogs about342899-38-1

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: isoquinoline. Introducing a new discovery about 342899-38-1, Name is 3-Chloroisoquinolin-4-amine

Preparation of 4-substituted 3-amino-2-chloropyridines, synthesis of a nevirapine analogue

A new method for preparing 3-amino-2-chloropyridines with a substituent (methyl, phenyl, carboxamide, methoxycarbonyl, acetyl, benzoyl and cyano) at the 4-position has been developed. An isoquinoline analogue of the reverse transcriptase inhibitor Nevirapine has been synthesized from the 4-amino-3-chloroisoquinoline.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: isoquinoline, you can also check out more blogs about342899-38-1

Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H2133N – PubChem